Search results for "Refractory"

New ion-guide for the production of beams of neutron-rich nuclei between Z=20–28

2005

It has been shown for the first time that quasi- and deep-inelastic reactions can be successfully incorporated into the conventional Ion-Guide Isotope Separator On-Line (IGISOL) technique. This is of particular interest for characterizing the decay properties of refractory elements and is applied to neutron rich nuclei between Z = 20-28. As a first step of this project, the kinematics of quasi- and deep-inelastic reactions, such as {sup 197}Au({sup 65}Cu,X)Y, were studied. Based on these studies, a specialized IGISOL target chamber was designed and built. This chamber was tested in on- and off-line conditions at the Jyvaskyla IGISOL facility. Yields of radioactive, projectile-like species s…

Judging the contact-times of multiple objects: Evidence for asymmetric interference.

2009

The accuracy of time-to-contact (TTC) judgments for single approaching objects is well researched, however, close to nothing is known about our ability to make simultaneous TTC judgments for two or more objects. Such complex judgments are required in many everyday situations, for instance when crossing a multi-lane street or when engaged in multi-player ball games. We used a prediction-motion paradigm in which participants simultaneously estimated the absolute TTC of two objects, and compared the performance to a standard single-object condition. Results showed that the order of arrival of the two objects determined the accuracy of the TTC estimates: Estimation of the first-arriving object …

Device Therapy for Rate Control: Pacing, Resynchronisation and AV Node Ablation

2017

Atrioventricular node ablation (AVNA) is generally reserved for patients whose atrial fibrillation (AF) is refractory all other therapeutic options, since the recipients will often become pacemaker dependent. In such patients, this approach may prove particularly useful, especially if a tachycardia-induced cardiomyopathy is suspected. Historically, an "ablate and pace" approach has involved AVNA and right ventricular pacing, with or without an atrial lead. There is also an evolving role for atrioventricular node ablation in patients with AF who require cardiac resynchronisation therapy for treatment of systolic heart failure. A mortality benefit over pharmacotherapy has been demonstrated in…

Setting the Scene: Element Determination and its Quality Control in Fractions of Refractory Organic Substances and the Corresponding Original Water S…

2007

Synthesis of refractory metal nuggets and constraints on the thermal histories of nugget-bearing Ca, Al-rich inclusions

2015

Tiny refractory metal nuggets are mainly observed inside Ca, Al-rich inclusions (CAIs) from chondritic meteorites and are commonly assumed to be condensates from a solar composition gas. However, recent detailed studies of metal nugget compositions and their comparison with predictions from condensation show that the observed abundance patterns are extremely difficult to achieve in this way. As a test for the proposed alternative, precipitation from a silicate liquid, we conducted melting experiments, in which nine different refractory metals (nugget components) were equilibrated with each other along with a CAI-like liquid at reducing conditions. When quenched, minerals similar to those in…

Sub 500 nm refractory carbonaceous particles in the polar stratosphere

2017

Abstract. Eleven particle samples collected in the polar stratosphere during SOLVE (SAGE III Ozone loss and validation experiment) from January until March 2000 were characterized in detail by high-resolution transmission and scanning electron microscopy (TEM/SEM) combined with energy-dispersive X-ray microanalysis. A total number of 4175 particles (TEM = 3845; SEM = 330) was analyzed from these samples which were collected mostly inside the polar vortex in the altitude range between 17.3 and 19.9 km. By particle volume, all samples are dominated by volatile particles (ammonium sulfates/hydrogen sulfates). By number, approximately 28–82 % of the particles are refractory carbonaceous with si…

Belinostat, a novel pan-histone deacetylase inhibitor (HDACi), in relapsed or refractory peripheral T-cell lymphoma (R/R PTCL): Results from the BELI…

2013

8507 Background: Therapies approved in US for R/R PTCL have overall response rates (ORR) of 25%-27%. The need for new therapies persists. BELIEF is a pivotal, single-arm study of belinostat in patients with R/R PTCL after failure of ≥1 prior systemic therapies. Methods: Entry criteria were measurable PTCL, platelets ≥ 50,000/µL, no prior HDACi therapy, and adequate organ function. PTCL was confirmed by central pathology review (CPRG). Belinostat 30 min IV infusion at 1000 mg/m2was administered on days 1–5 of a 3 week cycle until progression or unacceptable toxicity. Tumor response was assessed by Cheson 2007 criteria. The primary endpoint was ORR. Results: Patients with R/R PTCL (N=129, 53…

Real-World Evidence of Tisagenlecleucel for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma

2020

Introduction Tisagenlecleucel (tisa-cel) is a second generation, CD19-targeted Chimeric Antigen Receptor (CAR) T-cell therapy for relapsed or refractory (R/R) large B-cell lymphoma (LBCL). The pivotal phase 2 trial JULIET included 93 patients and reported an overall response rate (ORR) of 52% and a complete response rate of 40% among treated patients. However, very little is known regarding its safety and efficacy in the commercial or real-world setting as well as from an intention-to-treat perspective. In our study, we report clinical outcomes of patients with R/R LBCL treated with commercial tisa-cel in 10 Spanish institutions. Methods Data were collected retrospectively from all consecut…

Refractory SAPHO Syndrome Involving the Mandible

2014

Are high-temperature fractionations in the solar nebula preserved in highly siderophile element systematics of the Earth's mantle?

2004

The relative abundances of the highly siderophile elements (HSE) Os, Ir, Ru, Pt, Rh, and Pd in relatively pristine lherzolites differ from solar abundance ratios and are several orders of magnitude higher than predicted for equilibrium distribution between metal/silicate (core-mantle). The samples are characterized by a mean Ca/Al ratio of 1.18 ± 0.09 σM and a mean Ca/Si ratio of 0.10 ± 0.01 σM, overlapping with a mean Ca/Al of 1.069 ±  0.044 σM and a mean Ca/Si of 0.081 ± 0.023 σM found in chondrites (Wasson and Kallemeyn 1988). Interestingly, the CI-normalized abundance pattern shows decreasing solar system normalized abundances with increasing condensation temperatures. The abundance of …