Search results for "Regular Article"
showing 10 items of 102 documents
Development of a three-dimensional cell culture system based on microfluidics for nuclear magnetic resonance and optical monitoring
2014
A new microfluidic cell culture device compatible with real-time nuclear magnetic resonance (NMR) is presented here. The intended application is the long-term monitoring of 3D cell cultures by several techniques. The system has been designed to fit inside commercially available NMR equipment to obtain maximum readout resolution when working with small samples. Moreover, the microfluidic device integrates a fibre-optic-based sensor to monitor parameters such as oxygen, pH, or temperature during NMR monitoring, and it also allows the use of optical microscopy techniques such as confocal fluorescence microscopy. This manuscript reports the initial trials culturing neurospheres inside the micro…
Aerobic fitness mediates the intervention effects of a school-based physical activity intervention on academic performance. The school in Motion stud…
2021
Highlights • Physical activity is associated with increased aerobic fitness and academic performance. • Little is known on mechanism of physical activity effects on academic performance. • We performed a cluster randomized controlled trial. • Aerobic fitness mediated the intervention effect on academic performance. • Activity increasing aerobic fitness is a strategy to improve academic performance.
The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia
2020
Abstract Background Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive disorder (MDD), educational attainment (EA), and IQ, but very few studies have examined associations between these PRS and cognitive phenotypes within schizophrenia cases. Methods We combined genetic and cognitive data in 3034 schizophrenia cases from 11 samples using the general intelligence factor g as the primary measure of cognition. We used linear regression to examine the association between cognition and PRS for EA, IQ, schizophrenia, BD, and MDD. The results wer…
Frequency-specific network activity predicts bradykinesia severity in Parkinson’s disease
2021
Highlights • Parallel subnetworks are affected in bradykinesia. • The primary motor and the premotor cortex are common nodes with task-specificity. • Beta activity decreases, gamma activity increases with improvement of bradykinesia. • Subthalamic stimulation reduces beta, increases gamma power in ipsilateral cortex. • Subnetworks act with frequency-specific oscillations.
Parental alcohol intoxication and adverse health outcomes among offspring. A 4-year follow up HUNT study among 2399 Norwegian adolescents.
2020
Highlights • Alcohol’s harm to others includes adverse health outcomes in adolescence. • Non-dependent parental heavy drinking increases health harm among adolescents. • Hospital admission was related to exposure to parental alcohol intoxication. • Mental distress was related to exposure to parental alcohol intoxication. • Poor self-rated health was related to exposure to parental alcohol intoxication.
An analysis of the impact of LHC Run I proton–lead data on nuclear parton densities
2016
We report on an analysis of the impact of available experimental data on hard processes in proton-lead collisions during Run I at the Large Hadron Collider on nuclear modifications of parton distribution functions. Our analysis is restricted to the EPS09 and DSSZ global fits. The measurements that we consider comprise production of massive gauge bosons, jets, charged hadrons and pions. This is the first time a study of nuclear PDFs includes this number of different observables. The goal of the paper is twofold: i) checking the description of the data by nPDFs, as well as the relevance of these nuclear effects, in a quantitative manner; ii) testing the constraining power of these data in eve…
Monopole production via photon fusion and Drell-Yan processes: MADGRAPH implementation and perturbativity via velocity-dependent coupling and magneti…
2018
In this work we consider point-like monopole production via photon-fusion and Drell-Yan processes in the framework of an effective U(1) gauge field theory obtained from conventional models describing the interaction of spin 0, 1/2, 1 magnetically-charged fields with ordinary photons, upon electric-magnetic dualisation. We present arguments based on such dualities which support the conjecture of an effective monopole-velocity-dependent magnetic charge. For the cases of spin-1/2 and spin-1 monopoles, we also include a magnetic-moment term kappa, which is treated as a new phenomenological parameter and, together with the velocity-dependent coupling, allows for a perturbative treatment of the c…
Photons, Photon Jets and Dark Photons at 750 GeV and Beyond
2016
In new physics searches involving photons at the LHC, one challenge is to distinguish scenarios with isolated photons from models leading to "photon jets". For instance, in the context of the 750 GeV diphoton excess, it was pointed out that a true diphoton resonance $S \to \gamma\gamma$ can be mimicked by a process of the form $p p \to S \to a a \to 4\gamma$, where $S$ is a new scalar with a mass of 750 GeV and $a$ is a light pseudoscalar decaying to two collinear photons. Photon jets can be distinguished from isolated photons by exploiting the fact that a large fraction of photons convert to an $e^+e^-$ pair inside the inner detector. In this note, we quantify this discrimination power, an…
The ultraviolet landscape of two-Higgs doublet models
2018
We study the predictions of generic ultraviolet completions of two-Higgs doublet models. We assume that at the matching scale between the two-Higgs doublet model and a ultraviolet complete theory -- which can be anywhere between the TeV and the Planck scale -- arbitrary but perturbative values for the quartic couplings are present. We evaluate the couplings down from the matching scale to the weak scale and study the predictions for the scalar mass spectrum. In particular, we show the importance of radiative corrections which are essential for both an accurate Higgs mass calculation as well as determining the stability of the electroweak vacuum. We study the relation between the mass splitt…
SPARC oppositely regulates inflammation and fibrosis in bleomycin-induced lung damage.
2011
Fibrosis results from inflammatory tissue damage and impaired regeneration. In the context of bleomycin-induced pulmonary fibrosis, we demonstrated that the matricellular protein termed secreted protein acidic and rich in cysteine (SPARC) distinctly regulates inflammation and collagen deposition, depending on its cellular origin. Reciprocal Sparc(-/-) and wild-type (WT) bone marrow chimeras revealed that SPARC expression in host fibroblasts is required and sufficient to induce collagen fibrosis in a proper inflammatory environment. Accordingly, Sparc(-/-) >WT chimeras showed exacerbated inflammation and fibrosis due to the inability of Sparc(-/-) macrophages to down-regulate tumor necrosis …