Search results for "Regular Article"
showing 10 items of 102 documents
Adipose tissue sensitivity to radiation exposure
2008
1525-2191 (Electronic) Journal Article Research Support, Non-U.S. Gov't; Treatment of cancer using radiation can be significantly compromised by the development of severe acute and late damage to normal tissue. Treatments that either reduce the risk and severity of damage or that facilitate the healing of radiation injuries are being developed, including autologous adipose tissue grafts to repair tissue defects or involutional disorders that result from tumor resection. Adipose tissue is specialized in energy storage and contains different cell types, including preadipocytes, which could be used for autologous transplantation. It has long been considered a poorly proliferative connective ti…
Neutron-skin effect in direct-photon and charged hadron-production in Pb+Pb collisions at the LHC
2017
A well-established observation in nuclear physics is that in neutron-rich spherical nuclei the distribution of neutrons extends farther than the distribution of protons. In this work, we scrutinize the influence of this so called neutron-skin effect on the centrality dependence of high-$p_{\rm T}$ direct-photon and charged-hadron production. We find that due to the estimated spatial dependence of the nuclear parton distribution functions, it will be demanding to unambiguously expose the neutron-skin effect with direct photons. However, when taking a ratio between the cross sections for negatively and positively charged high-$p_{\rm T}$ hadrons, even centrality-dependent nuclear-PDF effects …
Geonic black holes and remnants in Eddington-inspired Born–Infeld gravity
2014
We show that electrically charged solutions within the Eddington-inspired Born–Infeld theory of gravity replace the central singularity by a wormhole supported by the electric field. As a result, the total energy associated with the electric field is finite and similar to that found in the Born–Infeld electromagnetic theory. When a certain charge-to-mass ratio is satisfied, in the lowest part of the mass and charge spectrum the event horizon disappears, yielding stable remnants. We argue that quantum effects in the matter sector can lower the mass of these remnants from the Planck scale down to the TeV scale.
Higgs decay into two photons in a warped extra dimension
2014
A detailed five-dimensional calculation of the Higgs-boson decay into two photons is performed in both the minimal and the custodially protected Randall–Sundrum (RS) model, where the Standard Model (SM) fields propagate in the bulk and the scalar sector lives on or near the IR brane. It is explicitly shown that the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$R_\xi $$\end{document}Rξ gauge invariance of the sum of diagrams involving bosonic fields in the SM also applies to the case of these RS scenarios. An e…
Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death.
2008
Hypoxia and the acquisition of a glycolytic phenotype are intrinsic features of the tumor microenvironment. The hypoxia inducible factor-1alpha (HIF-1alpha) pathway is activated under hypoxic conditions and orchestrates a complex transcriptional program that enhances cell survival. Although the consequences of HIF-1alpha inactivation in cancer cells have been widely investigated, only a few studies have addressed the role of HIF-1alpha in the survival of cancer cells endowed with different glycolytic capacities. In this study, we investigated this aspect in ovarian cancer cells. Hypoxia-induced toxicity was increased in highly glycolytic cells compared with poorly glycolytic cells; it was a…
Differential Roles of JNK in ConA/GalN and ConA-Induced Liver Injury in Mice
2008
Tumor necrosis factor-alpha-mediated liver injury can be induced by several different means; however, the signaling events and mechanisms of cell death are likely different. We investigated the mechanism of both apoptotic and necrotic hepatocyte cell death as well as the role of c-Jun NH2-terminal kinase (JNK) in the ConA and ConA/D-galactosamine (GalN) models of murine liver injury. ConA alone induced primarily necrotic cell death with no caspase activation, whereas ConA/GalN induced apoptosis in addition to necrotic cell death. The bi-modal death pattern in the ConA/GalN model was confirmed by the use of transgenic mice expressing a dominant-negative form of Fas-associated death domain in…
Disturbed structural connectivity in schizophrenia primary factor in pathology or epiphenomenon?
2007
Indirect evidence for disturbed structural connectivity of subcortical fiber tracts in schizophrenia has been obtained from functional neuroimaging and electrophysiologic studies. During the past few years, new structural imaging methods have become available. Diffusion tensor imaging and magnetization transfer imaging (MTI) have been used to investigate directly whether fiber tract abnormalities are indeed present in schizophrenia. To date, findings are inconsistent that may express problems related to methodological issues and sample size. Also, pathological processes detectable with these new techniques are not yet well understood. Nevertheless, with growing evidence of disturbed structu…
EPPS16: Nuclear parton distributions with LHC data
2017
We introduce a global analysis of collinearly factorized nuclear parton distribution functions (PDFs) including, for the first time, data constraints from LHC proton-lead collisions. In comparison to our previous analysis, EPS09, where data only from charged-lepton-nucleus deep inelastic scattering (DIS), Drell-Yan (DY) dilepton production in proton-nucleus collisions and inclusive pion production in deuteron-nucleus collisions were the input, we now increase the variety of data constraints to cover also neutrino-nucleus DIS and low-mass DY production in pion-nucleus collisions. The new LHC data significantly extend the kinematic reach of the data constraints. We now allow much more freedom…
Dipole operator constraints on composite Higgs models
2014
Flavour- and CP-violating electromagnetic or chromomagnetic dipole operators in the quark sector are generated in a large class of new physics models and are strongly constrained by measurements of the neutron electric dipole moment and observables sensitive to flavour-changing neutral currents, such as the $B\to X_s\gamma$ branching ratio and $\epsilon'/\epsilon$. After a model-independent discussion of the relevant constraints, we analyze these effects in models with partial compositeness, where the quarks get their masses by mixing with vector-like composite fermions. These scenarios can be seen as the low-energy limit of composite Higgs or warped extra dimensional models. We study diffe…
Inclusive quarkonium production at forward rapidity in pp collisions at \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usep…
2016
We report on the inclusive production cross sections of \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\mathrm{J}/\psi }$$\end{document}J/ψ, \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${\psi (\mathrm{2S})}$$\end{document}ψ(2S), \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepac…