Search results for "Relative"

A new cure model accounting for extra non-cancer mortality: Validation and application to real data

2021

Introduction The proportion of cancer patients cured of the disease is estimated with standard cure models assuming they have the same risk of death as the general population [1] . These patients, however often maintain an extra risk of dying compared to the overall population, which we assume is due to other causes than cancer [2] . The aim of the work was to develop and validate an extended cure model incorporating the estimated patients’ relative risk of death from other causes (α) compared to that observed in the general population. Methods We extended the mixture cure model considering Weibull relative survival of the uncured by including a relative risk αwhich muliptlies the mortality…

Data Analysis of Epidemiological Studies

2010

Epidemiology is used to describe the distribution of diseases in the population and to analyze the causes of these diseases. One important objective is to identify risk factors and to quantify their significance. A risk factor can influence the probability that a specific disease develops. Risk factors include: Environmental influences (for example, exposure to radon) Predisposition (for example, genes), or Behavioral characteristics (for example, hormone intake). Epidemiological research employs various different types of study (1–3), depending on the question asked. The most important are Cohort studies Case-control studies, and Cross-sectional studies In cohort studies, persons exposed t…

2020

ObjectivesResponding to the mental health needs of refugees remains a pressing challenge worldwide. We estimated the prevalence of psychological distress in a large refugee population in Germany and assessed its association with host country factors amenable to policy intervention and integration indicators.DesignA cross-sectional and population-based secondary analysis of the 2017 wave of the IAB-BAMF-SOEP refugee survey.SettingGermany.Participants2639 adult refugees who arrived in Germany between 2013 and 2016.Main outcome measuresPsychological distress involving symptoms of depression, anxiety and post-traumatic stress disorder was measured using the Refugee Health Screener-13.ResultsAlm…

Cancer colorectal : du diagnostic au dépistage

2009

Colorectal cancer fulfils the conditions required for mass screening. Data from controlled studies indicate that it is possible to reduce colorectal cancer mortality at a population level using faecal occult blood testing. Screenings rely on biennial testing in between 50 and 74average risk subjects. Compliance must be over 50%. Colorectal cancer mortality decrease in this case between 15 and 18% in the general population, 33 and 39% among participants to screening. The European Commission, on the basis of available data recommended to organise colorectal cancer screening in the European Union. Generalisation of screening has become a reality in France. Epidemiological studies allow us to d…

Correlative Raman-Electron-Light (CREL) Microscopy Analysis of Lipid Droplets in Melanoma Cancer Stem Cells.

2022

Among all neoplasms, melanoma is characterized by a very high percentage of cancer stem cells (CSCs). Several markers have been proposed for their identification, and lipid droplets (LDs) are among them. Different techniques are used for their characterization such as mass spectrometry, imaging techniques, and vibrational spectroscopies. Some emerging experimental approaches for the study of LDs are represented by correlative light–electron microscopy and by correlative Raman imaging–scanning electron microscopy (SEM). Based on these scientific approaches, we developed a novel methodology (CREL) by combining Raman micro-spectroscopy, confocal fluorescence microscopy, and SEM coupled with an…

Generation of homozygosity and genome fixation in pea (Pisum sativum L.)

2013

Pea cultivars are nearly homozygous and thus homogeneous when they are released. The traditional method of selfing is slow and inefficient, taking up to ten generations of inbreeding following a cross to achieve a high level of homozygosity. Current single-seed-descent (SSD) methodologies enable a maximum of three generations per year to be developed in pea. Doubled haploidy and an in vitro based modified SSD technology have been utilised in many important crops for the rapid achievement of homozygosity, and thus acceleration of the breeding process. In pea, due to the lack of robust protocols, none of these technologies is routinely used in a breeding program. The aim of this study was to …

Risk of Low Energy Availability, Disordered Eating, Exercise Addiction, and Food Intolerances in Female Endurance Athletes

2022

Relative energy deficiency in sport (RED-S) is a complex syndrome describing health and performance consequences of low energy availability (LEA) and is common among female endurance athletes. Various underlying causes of LEA have been reported, including disordered eating behavior (DE), but studies investigating the association with exercise addiction and food intolerances are lacking. Therefore, the aim of this cross-sectional study was to investigate the association between DE, exercise addiction and food intolerances in athletes at risk of LEA compared to those with low risk. Female endurance athletes, 18–35 years, training ≥5 times/week were recruited in Norway, Sweden, Ireland, and Ge…

Sorption kinetic of aroma compounds by edible bio-based films from marine-by product macromolecules: Effect of relative humidity conditions

2019

International audience; Edible films based on gelatin and chitosan have high gas and aroma barrier properties. This study focused on their capability to sorbed/retain aroma compounds (1-hexanal, 2-hexen-1-ol, 1-hexanol, 3-hexanone and phenol) at three relative humidity level (≤2%, 53% or 84% RH). Whatever the relative humidity condition, the order of sorption is keton (3-hexanone) < aldehyde (1-hexanal) < aliphatic alcohols (2-hexen-1-ol and 1-hexanol) < phenol. This order could be related to the intrinsic chemical properties of aroma compounds. The increase in moisture enhanced the sorption at the highest RH for all the aroma compounds. However, a competition between water and aliphatic al…

Observational Results On The Influence Of Surface Layer Stability And Inversion Entrainment On Surface Layer Marine Aerosol Number Density (1 Microme…

1983

Wind speed and relative humidity have been the physical variables used in empirical expressions for equilibrium marine aerosol distributions. Recent formulations, which include the role of hydrostatic stability because it influences turbulent transport and entrainment of clear air from aloft, are examined on the basis of 1 um radius aerosol number density values. The aerosol data were collected along with a quite complete meteorological data set in the Northeast Atlantic during the international Joint Air Sea Interaction Experiment (JASIN-78). The 1 um number density values are normalized for generation and relative humidity influences, and analyses are performed to gain reasonable assuranc…

Quasisymmetric extension on the real line

2015

We give a geometric characterization of the sets $E\subset \mathbb{R}$ that satisfy the following property: every quasisymmetric embedding $f: E \to \mathbb{R}^n$ extends to a quasisymmetric embedding $f:\mathbb{R}\to\mathbb{R}^N$ for some $N\geq n$.