Search results for "Renal cell carcinoma"
showing 4 items of 164 documents
Genetic profile and immunohistochemical study of clear cell renal carcinoma: Pathological-anatomical correlation and prognosis.
2021
Abstract Introduction Renal cell carcinoma (RCC) accounts for 2–3% of all tumors being the most frequent solid lesion in the kidney. Objective To determine what genetic alterations and immunohistochemical (IHC) of clear cell renal carcinoma (ccRCC) are associated with prognosis and tumor aggressiveness. Patients and Methods Experimental analytical study with 57 patients who underwent radical and partial nephrectomy between 2005 and 2011, all with diagnosis of ccRCC and minimum post-operative follow-up of 36 months. The pathological study included IHC determination of biomarkers associated (CAIX, CAM 5.2, CD10, c-erbB-2, EGFR, HIF-1a, Ki67, MDM2, PAX-2 y 8, p53, survivin and VEGFR 1 and 2). …
Antitumor Effect of Cabozantinib in Bone Metastatic Models of Renal Cell Carcinoma
2021
Background: The presence of bone metastases in renal cell carcinoma (RCC) negatively affects patients’ survival. Data from clinical trials has highlighted a significant benefit of cabozantinib in bone metastatic RCC patients. Here, we evaluated the antitumor effect of cabozantinib in coculture models of renal cell carcinoma (RCC) and osteoblasts (OBs) to investigate whether and how its antiproliferative activity is influenced by OBs. Methods: Bone/RCC models were generated, coculturing green fluorescent protein (GFP)-tagged Caki-1 and 786-O cells with human primary OBs in a “cell–cell contact” system. RCC proliferation and the OB molecular profile were evaluated after the cabozantinib treat…
Nieru audzēju klīniski morfoloģiskais raksturojums
2020
Saslimstība ar ļaundabīgajiem nieru audzējiem palielinās katru gadu, visizteiktāk tas vērojams pasaules attīstītajās valstīs, kā arī Latvijā. Nieru šūnu karcinoma ir viens no visbiežākajiem ļaundabīgajiem nieru audzējiem. Agrīnajās stadijās nieru šūnu karcinomai nav raksturīga kāda konkrēta simptomātika un lielākajā daļā gadījumu, tā tiek diagnosticēta netīši- veicot izmeklējumus kādas citas saslimšanas gadījumā. Pēc tam, kad audzējs ir ticis diagnosticēts, ir būtiski izvērtēt pacienta vispārējo stāvokli un riska faktorus, no kā ir atkarīga pacientu kopējā dzīvildze un recidīva risks. Ja iespējams, noteikt histoloģisko nieru šūnu karcinomas subtipu un ņemot vērā šos faktorus, izvēlēties pie…
Pringle maneuver during open partial nephrectomy for renal tumors
2017
Introduction. Sparing kidney tissue is important because studies show that patients who have their entire kidney removed are more likely to suffer from chronic kidney disease after surgery than patients who received a kidney-sparing partial nephrectomy. The aim of study is to show the effectives of Pringle maneuver for clamping renal pedicle in order to minimize warm ischemia during open partial nephrectomy. Material and method. We retrospectively analyzed 34 patients diagnosed with cT1 renal tumors between 2012 and 2016 and underwent open partial nephrectomy in Sibiu Urology Department. During the surgery we perform clamping of renal pedicle with Satinsky clamp or with the Pringle maneuver…