Search results for "Repair"
showing 10 items of 747 documents
Current Perspectives on Adult Mesenchymal Stromal Cell-Derived Extracellular Vesicles: Biological Features and Clinical Indications.
2022
Extracellular vesicles (EVs) constitute one of the main mechanisms by which cells communicate with the surrounding tissue or at distance. Vesicle secretion is featured by most cell types, and adult mesenchymal stromal cells (MSCs) of different tissue origins have shown the ability to produce them. In recent years, several reports disclosed the molecular composition and suggested clinical indications for EVs derived from adult MSCs. The parental cells were already known for their roles in different disease settings in regulating inflammation, immune modulation, or transdifferentiation to promote cell repopulation. Interestingly, most reports also suggested that part of the properties of pare…
Gene amplification in fibroblasts from ataxia telangiectasia (AT) patients and in X-ray hypersensitive AT-like Chinese hamster mutants
2001
In search of functions involved in the regulation of gene amplification, and given the relevance of chromosome breakage in initiating the process, we analyzed the gene amplification ability of cells hypersensitive to inducers of DNA double-strand breaks and defective in cell cycle control: two human fibroblast strains derived from patients affected by ataxia telangiectasia (AT) and two hamster mutant cell lines belonging to complementation group XRCC8 of the rodent X-ray-sensitive mutants. These mutants are considered hamster models of AT cells. To measure gene amplification, the frequency and the rate of occurrence of N-(phosphonacetyl)-l-aspartate resistant cells were determined. In both …
EXPERIMENTAL ANALYSIS OF SMALL CLAY BRICK CYLINDERS CONFINED BY BFRP GRID UNDER AXIAL COMPRESSION
2019
Many investigations have shown that fibre reinforced polymer (FRP) composites can be effectively used to induce a passive confinement action on masonry columns and improve their axial capacity and ductility. This paper presents the results of an experimental study on the compressive behaviour of clay brick masonry cylinders externally wrapped with basalt fiber reinforced polymer (BFRP) grids. The circular section shape was chosen to assess the pure confinement effect on the masonry material. Fourteen clay brick masonry cylinders, cored from two different masonry assembly types, were confined with one or two layers of BFRP grids. The two assemblies were used to investigate the effect of vert…
BFRP grid confined clay brick masonry cylinders under axial compression: Experimental results
2018
The use of composite materials for retrofitting of masonry structures has received great attention during the last two decades. For masonry buildings there are several advantages in using composite materials. Traditional techniques that were largely used and investigated in the past, may be inadequate in seismic areas where the added mass could increase seismic actions. Moreover, for historical and architectural heritage structures, the compatibility, sustainability and reversibility of the intervention is a key factor for the selection of the most appropriate strengthening system. Many investigations have shown that fibre reinforced polymers (FRP) can be effectively used to induce a passiv…
An experimental study on the compressive behaviour of calcarenite masonry columns wrapped by fiber reinforced mortar wraps
2018
The use of Fiber Reinforced Cementitious Mortar (FRCM) systems for structural retrofitting of masonry structures has become increasingly popular in the last years, due to the capability of this technique in overcoming some of the drawbacks related to the adoption of resin-based composites. In fact, FRCM systems ensure good compatibility between the reinforcing layers and the substrate, achieving also the removability requirement, which is of fundamental importance for historical constructions. Recent research studies focused on the mechanical performance of FRCM materials, by studying its tensile behaviour and bond between the strengthening layer and masonry, pointing out as failure is alwa…
Theoretical construct, method and working tool of the "preventive restoration". The electronic book for the prearranged maintenance of architectural …
2016
A restoration may constitute a positive moment to guarantee the conservation, transmission and a compatible use of an historical architecture, but it is often the result of a long and guilty omission of care, attesting a lack of interest in the architectural heritage we are late forced to heal with extensive and invasive interventions that, in most cases, could be prevented. Clear maintenance programs and a correct and well-planned preventive action could be sufficient to avoid unexpected interventions when it is too late; such simple concepts - apparently shared by everyone - however, remain relegated to a level of brainy attitudes or protocols that do not produce any advantage in terms of…
DIO SALVI IL RESTAURO. L’apporto inglese alla cultura della conservazione dei monumenti
2020
Sebbene già riuscissimo a percepire quanto rilevante fosse l’apporto inglese per aver contribuito alla definizione del restauro modernamente inteso, sino ad oggi mancavano ancora sia una chiara visione d’insieme delle articolate vicende connesse all'affermazione dei princìpi conservativi, sia una più approfondita conoscenza delle fonti documentarie, necessarie al fine di tracciare i profili culturali dei protagonisti e scandagliarne i contributi teorici. La ricostruzione delle vicende è sviluppata entro margini temporali estesi all'incirca per tre secoli, dalla fine del Seicento al principio del Nove-cento, e strutturata attraverso la traduzione e lo studio di testi perlopiù mai circolati i…
On the transient response of actively repaired damaged structures by the boundary element method
2010
The transient fracture mechanics behavior of damaged structures repaired through active piezoelectric patches is presented in this paper. The analyses have been performed through a boundary element code implemented in the framework of piezoelectricity to take account of the coupling between the elastic and the electric fields, which represents the peculiar feature of piezoelectric media. The multi-domain technique has been also involved to assemble the host structures and the active patches and to model the cracks. Moreover, the patches have been considered elastically bonded to the damaged structure by means of a zero thickness adhesive layer. This has been achieved through the implementat…
Can the tumor-agnostic evaluation of MSI/MMR status be the common denominator for the immunotherapy treatment of patients with several solid tumors?
2022
Alterations in short-repetitive DNA sequences, known as microsatellite instability (MSI), can reflect deficiencies in Mismatch Repair (MMR) system which represents a major player in DNA integrity maintenance. The incidence of MSI-H/dMMR has been shown to be variable depending on the tumor type. Several studies confirmed that dMMR/MSI status, although less frequent than PD-L1 expression, may better predict response to immune-checkpoint inhibitors (ICIs) in patients with solid tumors. In October 2016, the FDA granted pembrolizumab as breakthrough therapy for the treatment of non-CRC, MSI-H/dMMR tumors, providing, for the first time, a tumor-agnostic indication. In the next future, the tissue-…
Dynamic autostatic implant for inguinal hernia repair. Early results in an explorative cohort of patients
2010
Acknowledging the need to further improve outcomes and reduce complications in inguinal hernia repair, our group has been developing new surgical implants for this condition. Our primary considerations are to reduce complications associated with invasive fixation, and improve the quality of the tissue ingrowth within the implant. We have developed a new type of 3D dynamic, self retaining implant to achieve these effects. This newly designed implant was previously experimentally tested in porcine model, showing excellent outcomes. Above all, the results concerning the quality of tissue ingrowth and the nearby absence of shrinkage in the long term were excellent. In this report we describe th…