Search results for "Replica"

A Hebbian approach to complex-network generation

2011

Through a redefinition of patterns in an Hopfield-like model, we introduce and develop an approach to model discrete systems made up of many, interacting components with inner degrees of freedom. Our approach clarifies the intrinsic connection between the kind of interactions among components and the emergent topology describing the system itself; also, it allows to effectively address the statistical mechanics on the resulting networks. Indeed, a wide class of analytically treatable, weighted random graphs with a tunable level of correlation can be recovered and controlled. We especially focus on the case of imitative couplings among components endowed with similar patterns (i.e. attribute…

Value preserving portfolio strategies in continuous-time models

1997

We present a new approach for continuous-time portfolio strategies that relies on the principle of value preservation. This principle was developed by Hellwig (1987) for general economic decision and pricing models. The key idea is that an investor should try to consume only so much of his portfolio return that the future ability of the portfolio should be kept constant over time. This ensures that the portfolio will be a long lasting source of income. We define a continuous-time market setting to apply the idea of Hellwig to securities markets with continuous trading and examine existence (and uniqueness) of value-preserving strategies in some widely used market models. Further, we discuss…

Mechanism change in a simulation of peer review: from junk support to elitism

2014

Abstract Peer review works as the hinge of the scientific process, mediating between research and the awareness/acceptance of its results. While it might seem obvious that science would regulate itself scientifically, the consensus on peer review is eroding; a deeper understanding of its workings and potential alternatives is sorely needed. Employing a theoretical approach supported by agent-based simulation, we examined computational models of peer review, performing what we propose to call redesign, that is, the replication of simulations using different mechanisms. Here, we show that we are able to obtain the high sensitivity to rational cheating that is present in literature. In additio…

Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection.

2012

Abstract Regulatory T cells (Tregs) are important for the attenuation of immune reactions. During viral CNS infections, however, an indiscriminate maintenance of CNS immune privilege through Treg-mediated negative regulation could prevent autoimmune sequelae but impair the control of viral replication. We analyzed in this study the impact of Tregs on the development of acute viral encephalomyelitis, T cell-mediated antiviral protection, and prevention of CNS autoimmunity following intranasal infection with the gliatropic mouse hepatitis virus strain A59. To assess the contribution of Tregs in vivo, we specifically depleted CD4+Foxp3+ T cells in a diphtheria toxin-dependent manner. We found …

New Developments in Soft Lithography

2003

Abstract The burgeoning area of soft lithography is reviewed with special emphasis on developments within the past three years. Applications in electronics have driven such developments, but more recently, other kinds of device structures and 3D prototyping have also found application, in part, through soft lithography. Microcontact printing (μCP), “lift off” μCP nano transfer printing (nTP), micromolding in capillaries (MIMIC), solvent assisted micromolding (SAMIM), replica molding (REM), and microtransfer molding are the main soft lithography schemes discussed.

Replication crisis or an opportunity to improve scientific production?

2020

Evolution of oncolytic viruses.

2015

Owing to their replicative capacity, oncolytic viruses (OVs) can evolve under the action of natural selection. Reversion to virulence and recombination with wild-type strains may compromise OV safety, therefore requiring evolutionary risk assessment studies. On the other hand, evolution can be directed in the laboratory to create more potent and safer OVs. Previous work in the experimental evolution field provides a background for OV directed evolution, and has identified interesting exploitable features. While genetic engineering has greatly advanced the field of oncolytic virotherapy, this approach is sometimes curtailed by the complexity and diversity of virus-host interactions. Directed…

Flusso di informazione nella materia vivente

2019

Replicazione del DNA, Trascrizione, Maturazione dei trascritti, Maturazione dell'mRNA negli eucarioti, Maturazione di rRNA e tRNA negli eucarioti, Codice genetico, tRNA e aminoacil tRNA sintetasi, Ribosomi, Traduzione, Maturazione post-traduzionale e smistamento delle proteine, Gene, Regolazione dell'espressione genica.

Limited Usefulness of Capture Procedure and Capture Percentage for Evaluating Reproducibility in Psychological Science

2018

In psychological science, there is an increasing concern regarding the reproducibility of scientific findings. For instance, Replication Project: Psychology (Open Science Collaboration, 2015) found that the proportion of successful replication in psychology was 41%. This proportion was calculated based on Cumming and Maillardet’s (2006) widely employed capture procedure (CPro) and capture percentage (CPer). Despite the popularity of CPro and CPer, we believe that using them may lead to an incorrect conclusion of (a) successful replication when the population effect sizes in the original and replicated studies are different; and (b) unsuccessful replication when the population effect sizes i…

Misguided Effort with Elusive Implications

2016

Good self-control has been linked to adaptive outcomes such as better health, cohesive personal relationships, success in the workplace and at school, and less susceptibility to crime and addictions. In contrast, self-control failure is linked to maladaptive outcomes. Understanding the mechanisms by which self-control predicts behavior may assist in promoting better regulation and outcomes. A popular approach to understanding self-control is the strength or resource depletion model. Self-control is conceptualized as a limited resource that becomes depleted after a period of exertion resulting in self-control failure. The model has typically been tested using a sequential-task experimental p…