Search results for "Replica"
showing 10 items of 576 documents
Individual measurements and nested designs in aquaculture experiments: a simulation study
1998
Simple and nested models for analysis of variance (ANOVA) in aquaculture experiments were compared with the help of computer simulations. Simple models for analysing variables that are based on tank means, such as final weight and growth rate, were found to be sensitive to differences in the number of individual observations in each tank. In comparison to nested models that take into account individual measurements, the simple models were found to overestimate the F ratio and increase the risk of committing type I error, i.e., accepting a false alternative hypothesis. Further, nested models permit greater flexibility in experimental design, and allow more economical solutions within a given…
PARAMETER BOUNDED ESTIMATION FOR QUASISPECIES MODELS OF MOLECULAR EVOLUTION
2006
Abstract The Quasispecies models identification for Evolutionary Dynamics is considered in a worst-case deterministic setting. These models analyze the DNA and RNA evolution or describe the population dynamics of viruses and bacteria. In this paper we identify the Fitness and the Replication Probability parameters of a genetic sequences, subject to a set of stringent constraints to have physical meaning and to guarantee positiveness. The conditional central estimate and the Uncertainty Intervals are determined. The effectiveness of the proposed procedure has been illustrated by means of simulation experiments while tests on real data are under concern.
FANCD2 promotes mitotic rescue from transcription-mediated replication stress in SETX-deficient cancer cells
2022
AbstractReplication stress (RS) is a leading cause of genome instability and cancer development. A substantial source of endogenous RS originates from the encounter between the transcription and replication machineries operating on the same DNA template. This occurs predominantly under specific contexts, such as oncogene activation, metabolic stress, or a deficiency in proteins that specifically act to prevent or resolve those transcription-replication conflicts (TRCs). One such protein is Senataxin (SETX), an RNA:DNA helicase involved in resolution of TRCs and R-loops. Here we identify a synthetic lethal interaction between SETX and proteins of the Fanconi anemia (FA) pathway. Depletion of…
Phosphatidylserine liposomes reduce inflammatory response, mycobacterial viability and HIV replication in coinfected human macrophages
2021
AbstractChronic immune activation is the key pathogenetic event of Mycobacterium tuberculosis-human immunodeficiency virus (HIV) coinfection. We assessed the therapeutic value of phosphatidylserine-liposome (PS-L) in an in vitro model of M. tuberculosis-HIV coinfection. PS-L reduced nuclear factor-κB activation and the downstream production of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and IL-6 in bacille Calmette-Guérin-infected macrophages and of TNF-α and IL-1β in M. tuberculosis-infected and M. tuberculosis-HIV–coinfected macrophages. Importantly, a significant reduction of intracellular M. tuberculosis viability and HIV replication were also observed. These results suppor…
Digital contents as a tool to address research reproducibility crisis in psychology: A case study on sexual attraction under conditions of high arous…
2020
In the field of behavioral sciences, a crisis of the replicability of data took place. Among the reasons of the crisis, there is the difficulty of replicating some classical experimental settings and the lack of reproduced studies. Nowadays, digital contents might provide valuable opportunities to re-create specific environmental situations and manipulations in a safe and cost-saving way. The present study is a preliminary attempt to replicate the relationship between arousal manipulation and sexual attraction as it was assessed in the classical study by Dutton and Aron in 1974. Here, 30 male subjects will be randomly assigned to high or low arousal condition (induced with digital contents)…
The region 0.7615-0.796 m.u. of the HSV-1 genome determines suppression of humoral antibody formation against herpes simplex virus.
1991
The influence of genetic properties of parts of the HSV-1 genome on suppression of humoral antibody formation was investigated by using intratypic recombinants. The deleted strain HFEM (HSV-1) induces suppression. The MluI DNA fragment (coordinates 0.7615–0.796 m.u.) derived from the antibody inducing strain F1 (HSV-1) was transfected into the deleted strain HFEM to produce the recombinant virus R-MlCI and shown to restore antibody formation, as demonstrated by neutralization- and ELISA-tests. The intratypic recombinant viruses R-15, R-19 and R-26, produced by transfection of the Bam HI DNA-fragment B (0.738–0.809 m.u.) of strain Fl into the deleted strain HFEM, resulted in antibody formati…
Die Hemmung der Riesenzellbildung durch das sogenannte Compound 48/80 nach der Infektion mit dem Herpesvirus hominis
1969
Es wurde uber die Wirkung des Histamin-Liberators Compound 48/80 auf die Phasen der Synthese des Herpesvirus hominis und auf normale Zellstoffwechselprozessein vitro berichtet.
Molecular mechanisms of sorafenib action in liver cancer cells.
2012
Sorafenib, a multikinase inhibitor, recently received FDA approval for the treatment of advanced hepatocellular carcinoma (HCC). However, as the clinical application of sorafenib evolves, there is increasing interest in defining the mechanisms underlying its anti-tumor activity. Considering that this specific inhibitor could target unexpected molecules depending on the biologic context, a precise understanding of its mechanism of action could be critical to maximize its treatment efficacy, while minimizing adverse effects. Two human HCC cell lines (HepG2 and Huh7), carrying different biological and genetic characteristics, were used in this study to examine the intracellular events leading …
Is the p-Value a Suitable Basis for the Construction of Measures of Evidence? Comment on “The Role of p-Values in Judging the Strength of Evidence an…
2020
Dr. Gibson has to be congratulated for having enriched the wealth of articles written in response to the ASA statement on p-values of 2016 by a valuable and thoughtful contribution. We particularly...
Replication invariance on NTU games
2001
Two concepts of replication (conflictual and non-conflictual) are extended from the class of pure bargaining games to the class of NTU games. The behavior of the Harsanyi, Shapley NTU, Egalitarian and Maschler-Owen solutions of the replica games is compared with that of the Nash and Egalitarian solutions in pure bargaining games.