Search results for "Reproductive technology"
showing 10 items of 72 documents
The Principle of Respect for Human Vulnerability and Assisted Reproductive Technologies
2016
The chapter tackles the assisted reproductive technologies (ARTs), and the incorporation of two controversial procedures to increase the number of individuals who may satisfy their wish to have children: international commercial surrogacy and mitochondrial transfer. Both of them have an important point in common: the high degree of involvement within the reproduction process demanded to a different woman from the woman who will be the legal mother. In international surrogacy, a woman undergoes a baby gestation for another woman in a different country, who will be the legal mother since the baby is born. In mitochondrial transfer, a woman donates her eggs so that her mitochondria may be used…
The impact of next-generation sequencing technology on preimplantation genetic diagnosis and screening.
2013
Largely because of efforts required to complete the Human Genome Project, DNA sequencing has undergone a steady transformation with still-ongoing developments of high-throughput sequencing machines for which the cost per reaction is falling drastically. Similarly, the fast-changing landscape of reproductive technologies has been improved by genetic approaches. Preimplantation genetic diagnosis and screening were established more than two decades ago for selecting genetically normal embryos to avoid inherited diseases and to give the highest potential to achieve stable pregnancies. Most recent additions to the IVF practices (blastocyst/trophectoderm biopsy, embryo vitrification) and adoption…
340 EPIGENETIC ANALYSIS OF DEVELOPMENTALLY IMPORTANT GENES IN BOVINE OOCYTES OF DIFFERENT ORIGINS
2010
A critical step in assisted reproductive technologies (ART) is the IVM of oocytes. The quality of the oocyte is crucial for successful fertilization and subsequent embryo development. Studies in bovine ART, and epidemiological studies in children from ART, reveal a degree of abnormal development thought to be primarily caused by aberrant DNA methylation patterns in imprinted and non-imprinted genes. Due to the inherent similarities in bovine and human preimplantation embryonic development, bovine oocyte and embryo development is increasingly being used as a model for human development. The goal of this project is to investigate the effects of specific IVM conditions on the DNA methylation …
Assisted reproductive technology results: Why are live-birth percentages so low?
2014
The present bioessay aims to analyze the impact of parental age, cause of infertility, embryo chromosomal anomalies, assisted reproduction technology (ART) treatments, and environmental and occupational exposures to xenobiotics on ART results, particularly on live-birth percentages per transfer. Special attention is paid to analyzing the effects of these factors on the mitochondrial, genetic, and epigenetic traits of gametes and embryos to ascertain the molecular/cellular mechanisms responsible for the relatively low percentages of live births reported year after year in ART cycles. The bias of age distribution of women attending fertility clinics toward the late thirties and beyond and the…
261 INFLUENCE OF IN VITRO MATURATION ON EPIGENETIC MARKS AND GENE EXPRESSION IN BOVINE OOCYTES
2011
In cattle, in vitro maturation (IVM) of oocytes is an integral part of assisted reproduction technology. However, only 30% of in vitro matured bovine oocytes develop to the blastocyst stage after fertilization (compared with 60% for in vivo matured oocytes), indicating critical involvement of maturation conditions in the developmental competence of oocytes. Oocytes for IVF and intracytoplasmic sperm injection in humans are typically allowed to mature in vivo after superovulation because IVM is not considered to be a safe medical procedure. Several studies have shown that assisted reproduction technology involving prolonged in vitro culture of human and ruminant embryos can be associated wi…
Sociodemographic factors as determinants of quality of life and quality of social interactions among heterosexual couples undergoing assisted reprodu…
2021
Introduction When facing with stressful physical and psychosocial events, sociodemographic factors can be an important factor for quality of life and quality of social interactions [1]. The experience of infertile couples undergoing ART is a complex and stressful process that may have a negative effect on quality of life [2]. There is a need to better understand how certain sociodemographic factors impact on the quality of life and in the quality of social interactions of patients undergoing ART, in order to be able to anticipate the consequences from an integrated care perspective.MethodsThis study aims to assess the relationship between sociodemographic factors (sex, marital status and em…
Development, validation and clinical use of an expanded pan-ethnic preconception carrier genetic screening test in assisted reproductive technology p…
2015
Thirty-five years later, the first assisted reproductive technology program opens in Cambodia
2015
Laparoscopic management of quadruplet heterotopic pregnancy after ovarian stimulation cycle
2016
Introduction. We report a rare case of a heterotopic abdominal pregnancy with three intrauterine pregnancy, one with a viable fetus, treated successfully by laparoscopy. Methods. A 40-year-old patient with primary sterility, who un- derwent pharmacological ovulation induction, presented abdominal pain in the right iliac region. A trans-vaginal ultrasound showed an image suggestive of ectopic gestation near the right ovary, associated with three intrauterine gestational sacs with only one viable fetus. Basing on this observation, we performed an operative laparoscopy that confirmed the presence of a right ectopic abdominal pregnancy. Since the right ampullar tubal was ruptured and bleeding, …
Human papillomavirus infection in couples undergoing in vitro fertilization procedures: impact on reproductive outcomes.
2011
A prospective study was performed to assess the relationship between human papillomavirus (HPV) infection in 199 infertile couples and outcome of assisted reproductive technologies (ARTs). A highly statistically significant correlation between pregnancy loss rate (proportion of pregnancies detected by β-hCG that did not progress beyond 20 weeks) and positive HPV DNA testing in the male partner of infertile couples, compared with HPV negatives, was observed (66.7% vs. 15%).