Search results for "Research and development"
showing 10 items of 47 documents
Progressive active mobilization with dose control and training load in critically ill patients (PROMOB): Protocol for a randomized controlled trial
2020
The dose of progressive active mobilization is still uncertain. The purpose of this study is to identify if the addition of a protocol of progressive active mobilization with dose and training load control to usual care is effective in reducing the length of stay in intensive care unit (ICU) and the improvement of the functioning, incidence of ICU-acquired weakness (ICUAW), mechanical ventilation duration and mortality rate in patients hospitalized in ICU. It is Double-blind randomised clinical trial. The setting for this trial will be medical and surgical ICU of a university hospital. The study participants will be 118 patients aged> 18 years admitted to ICU for less than 72 hours. Partici…
Usual Care and Informed Consent in Clinical Trials of Oxygen Management in Extremely Premature Infants
2016
Objective The adequacy of informed consent in the Surfactant, Positive Pressure, and Pulse Oximetry Randomized Trial (SUPPORT) has been questioned. SUPPORT investigators and publishing editors, heads of government study funding agencies, and many ethicists have argued that informed consent was adequate because the two oxygen saturation target ranges studied fell within a range commonly recommended in guidelines. We sought to determine whether each oxygen target as studied in SUPPORT and four similar randomized controlled trials (RCTs) was consistent with usual care. Design/Participants/Setting PubMed, EMBASE, Web of Science, and Scopus were searched for English articles back to 1990 providi…
Tannins from Hamamelis virginiana Bark Extract: Characterization and Improvement of the Antiviral Efficacy against Influenza A Virus and Human Papill…
2014
Antiviral activity has been demonstrated for different tannin-rich plant extracts. Since tannins of different classes and molecular weights are often found together in plant extracts and may differ in their antiviral activity, we have compared the effect against influenza A virus (IAV) of Hamamelis virginiana L. bark extract, fractions enriched in tannins of different molecular weights and individual tannins of defined structures, including pseudotannins. We demonstrate antiviral activity of the bark extract against different IAV strains, including the recently emerged H7N9, and show for the first time that a tannin-rich extract inhibits human papillomavirus (HPV) type 16 infection. As the …
Managing IT implementation in virtual enterprises
1996
Konferansebidrag fra Engineering and Technology Management 1996 Vancouver. IEMC 1996 The paper presents a framework of factors influencing information technology (IT) implementation in virtual enterprises. The framework is based on previous research on IT implementation, and field studies conducted in virtual enterprises. The aim is to increase the understanding of the implementation process in this organizational context, and the framework is intended as a basis for developing strategies for successful management of this process
Pterostilbene-induced tumor cytotoxicity: a lysosomal membrane permeabilization-dependent mechanism.
2012
The phenolic phytoalexin resveratrol is well known for its health-promoting and anticancer properties. Its potential benefits are, however, limited due to its low bioavailability. Pterostilbene, a natural dimethoxylated analog of resveratrol, presents higher anticancer activity than resveratrol. The mechanisms by which this polyphenol acts against cancer cells are, however, unclear. Here, we show that pterostilbene effectively inhibits cancer cell growth and stimulates apoptosis and autophagosome accumulation in cancer cells of various origins. However, these mechanisms are not determinant in cell demise. Pterostilbene promotes cancer cell death via a mechanism involving lysosomal membrane …
Evaluation of the energy and environmental benefits of policies to support research and development
2022
Environmental innovations can play a central role in the fight against climate change. Also, the commitment of the international community in favor of the climate is reflected in particular by the implementation of policies for these innovations. This thesis studies the process in which these innovations appear in France, in particular the effects of environmental regulations, as well as their consequences on company performance.The challenges of this thesis are threefold: (i) contribute to a better understanding of the concept of environmental innovation; (ii) determine the strategic behavior of companies in terms of the dissemination of environmental innovations; (iii) develop an empirica…
Les incitations à l'innovation dans le secteur privé
2011
En ligne sur http://www.cairn.info/load_pdf.php?ID_ARTICLE=REL_792_0045; International audience; L'innovation est devenue un facteur clé de la croissance économique. La question des incitations à l'innovation au sein des entreprises est donc primordiale. Dans ce papier, nous nous intéressons au type d'incitations monétaires reçues par les inventeurs au sein des entreprises avec une attention particulière à la mobilité inter-entreprise de ces derniers. Les résultats montrent un rendement salarial positif pour les inventeurs, celui-ci est plus important pour les inventeurs ayant connu une mobilité inter-entreprise, ce qui pourrait suggérer que les entreprises sont prêtes à payer les connaissa…
eNOS Activation by HDL Is Impaired in Genetic CETP Deficiency.
2014
Mutations in the CETP gene resulting in defective CETP activity have been shown to cause remarkable elevations of plasma HDL-C levels, with the accumulation in plasma of large, buoyant HDL particles enriched in apolipoprotein E. Genetic CETP deficiency thus represents a unique tool to evaluate how structural alterations of HDL impact on HDL atheroprotective functions. Aim of the present study was to assess the ability of HDL obtained from CETP-deficient subjects to protect endothelial cells from the development of endothelial dysfunction. HDL isolated from one homozygous and seven heterozygous carriers of CETP null mutations were evaluated for their ability to down-regulate cytokine-induced…
Financial, organisational and informative involvement of the society in social innovation processes in Latvia
2018
International audience; Social innovation brings to inclusion and wellbeing, improving the quality of life and socioeconomic performance and enhancing the society's collective power and resources. Therefore, it is of utmost importance to promote social innovation processes in any society, providing research for getting the understanding of different aspects of it, including the main actors and the extent to which they are involved in social innovation. The research presented in this paper reveals the main stakeholders of social innovation and analyses the methodology elaborated by the authors for determining the involvement of the society in social innovation processes at financial, organis…
Ovine Carotid Artery-Derived Cells as an Optimized Supportive Cell Layer in 2-D Capillary Network Assays
2014
PLoS one 9(3), e91664 (2014). doi:10.1371/journal.pone.0091664