Search results for "Resistance"

2015

Globally, there is substantial concern regarding the challenges of treating complex drug resistance patterns in multidrug resistant tuberculosis cases. Utilising data from three different settings (Estonia, Latvia, Romania) we sought to contrast drug susceptibility profiles for multidrug resistant tuberculosis cases, highlight the difficulties in designing universal regimen, and inform future regimen selection. Demographic and microbiological surveillance data for multidrug resistant tuberculosis cases from 2004-13 were analysed. High levels of additional resistance to currently recommended second line drugs were seen in all settings, with extensive variability between countries. Accurate d…

Effects of physiotherapy interventions on balance in multiple sclerosis: A systematic review and meta-analysis of randomized controlled trials

2012

Objective: to determine the effects of physiotherapy inter ­ ventions on balance in people with multiple sclerosis. Data sources: A systematic literature search was conducted in Medline, cinahl, embase, PeDro, both electronically and by manual search up to March 2011. Study selection: Randomized controlled trials of physiothe­ rapy interventions in people with multiple sclerosis, with an outcome measure linked to the International Classifica­ tion of Functioning, Disability and Health (icF) category of “changing and maintaining body position”, were included. Data extraction: the quality of studies was determined by the van tulder criteria. Meta­analyses were performed in subgroups according…

Traditional vs daily undulling periodization in strength and local muscle endurance gains on trained men

2018

The aim of this study was to investigate the impact of different periodization models on strength and local muscle endurance. Twenty trained men (25.45 ± 2.984 years, 75.34 ± 6.05 kg, 177.25 ± 4.92 cm, 23.96 ± 1.64 kg . m-2) were randomly assigned in two groups: undulling periodization (UPG) and traditional periodization group (TPG), respectively. All the subjects performed one repetition maximum (1-RM) strength test and a local muscle endurance test (60% of 1-RM to failure) before, during and after experimental period. The UPG executed 30 workout sessions with daily modifications regarding intensity, volume and rest period length. The TGP was divided into 3 phases (10 workout sessions in e…

Use of Zoledronic Acid in a Neonate with Subcutaneous Fat Necrosis Complicated with Severe, Refractory Hypercalcemia.

2019

Objective Subcutaneous fat necrosis (SCFN) is a rare condition that may occur in the neonatal period. SCFN is an inflammatory disorder of the adipose tissue, usually found in full-term healthy infants who have a history of intrauterine or perinatal distress. It is usually a self-limited condition; however, in some cases, it can get complicated, leading to severe hypercalcemia that may be life-threatening. Study Design We report and describe a classic presentation of SCFN that led to severe hypercalcemia refractory to standard treatment. The diagnosis of SCFN was made based on the finding of subcutaneous nodules and of hypercalcemia. The serum calcium level reached 16.6 mg/dL. Hypercalcemia…

Dexamethasone suppresses eNOS and CAT-1 and induces oxidative stress in mouse resistance arterioles

2004

Long-term treatment with glucocorticoids is associated with mild to moderate hypertension. We reported previously that downregulation of endothelial NO synthase (eNOS) expression and activity is likely to contribute to this increase in blood pressure. In the present study, we tested the effects of dexamethasone on the vasodilation of microvascular arterioles using implanted dorsal skin-fold chambers in anesthetized C57BL/6J mice. Experiments were performed on control mice or on mice treated with dexamethasone (0.1–3 mg/kg of body wt). Endothelium-dependent vasodilation in response to ACh (0.1–10 μM) was reduced by dexamethasone in a dose-dependent fashion. Comparable inhibition was seen in …

Dietary intake of nutrients of great interest in immunonutrition to prevent muscle damage in soccer players

2008

Soccer is a sport in which players are exposed to long-term periods of training and players need to augment strength and fat-free massgains by resistance training, minimize muscle damage and soreness and help to improve endurance. Recently, the incidence of injuries hasincreased during and preceding soccer matches, which inuences the effectiveness of the team. One study

Knowledge Discovery from Microbiology Data: Many-Sided Analysis of Antibiotic Resistance in Nosocomial Infections

2005

Nosocomial infections and antimicrobial resistance (AR) are highly important problems that impact the morbidity and mortality of hospitalized patients as well as their cost of care. The goal of this paper is to demonstrate our analysis of AR by applying a number of various data mining (DM) techniques to real hospital data. The data for the analysis includes instances of sensitivity of nosocomial infections to antibiotics collected in a hospital over three years 2002-2004. The results of our study show that DM makes it easy for experts to inspect patterns that might otherwise be missed by usual (manual) infection control. However, the clinical relevance and utility of these findings await th…

Cardiovascular risk and events in polycystic ovary syndrome

2009

Young women with polycystic ovary syndrome (PCOS) present a high risk for cardiovascular disease because of the presence of abdominal obesity, insulin resistance and androgen excess. In addition, they present with endothelial dysfunction and early signs of atherosclerosis (increased carotid intima-media thickness and increased coronary calcium). However, the evidence of increased cardiovascular events during the postmenopausal age is relatively small, although some recent studies have indicated a slight increase in the severity of cardiovascular disease in women who had PCOS during their fertile age. The discrepancy between cardiovascular risk in young age and postmenopausal cardiovascular …

Not all women diagnosed with PCOS share the same cardiovascular risk profiles

2009

Although definitive and confirmatory data are lacking, women with polycystic ovary syndrome (PCOS) are considered to be at increased risk for cardiovascular and metabolic disease. In recent years, the diagnosis of PCOS has broadened considerably to result in several phenotypes. Here we review the evidence for cardiovascular and metabolic risks in PCOS in the classic disorder and the various phenotypes. We conclude that not all women with PCOS should be considered as being similar in terms of cardiovascular risk profiles.

Biophysics of venous return from the brain from the perspective of the pathophysiology of chronic cerebrospinal venous insufficiency

2011

This article discusses the biophysical aspects of venous outflow from the brain in healthy individuals and in patients with chronic cerebrospinal venous insufficiency. Blood flows out of the brain differently, depending on body position. In the supine position it flows out mainly through internal jugular veins, while in the upright position it uses the vertebral veins. This phenomenon is probably not due to the active regulation of the flow but instead results from the collapse of jugular veins when the head is elevated. Such a collapse is associated with a significant increase in flow resistance, which leads to redirection of the flow towards the vertebral pathway. Theoretical calculations…