Search results for "Resistant"

showing 10 items of 294 documents

Heat-Resistant Fully Bio-Based Nanocomposite Blends Based on Poly(lactic acid)

2013

Poly(lactic acid) (PLA) is melt mixed with polyamide 11 (PA11) to obtain a heat-resistant fully bio-based blend with PLA as the dominant component. The goal is achieved by adding small amounts of organoclay (OMMT), which is used to manipulate the blend microstructure. The selective positioning of the OMMT inside the PA11 and at the PLA/PA11 interface turns the blend morphology from drop/matrix into co-continuous at high PLA content (70 wt%). The OMMT-rich PA11 framework that interpenetrates the major PLA phase effectively contributes to bear stresses, and the nanocomposite blend keeps its structural integrity up to ≈160 °C, i.e., about 100 °C above the PLA glass transition.

Heat resistantNanocompositeMaterials sciencenanocompositePolymers and PlasticsBIOPOLYMERSGeneral Chemical EngineeringDrop (liquid)Organic Chemistrybiodegradable polymerMicrostructureNANOCOMPOSITESLactic acidchemistry.chemical_compoundPOLYMER BLENDSchemistryPolyamideMaterials ChemistryPLAOrganoclayComposite materialGlass transitionMacromolecular Materials and Engineering

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In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats

2019

Graphical abstract

In situPO Propylene oxideIV IntravenousP338 Poloxamer 338lcsh:RS1-441Pharmaceutical Sciencechemistry.chemical_compoundn Sample sizeSD Standard deviationIM Intramuscularchemistry.chemical_classificationC0 Analyte plasma concentration at time zeroDoE Design of experimentsUV UltravioletPharmacology. TherapyK2.EDTA Potassium ethylenediaminetetraacetic acidLC–MS/MS Liquid chromatography-tandem mass spectrometryH&E Hematoxylin and eosintmax Sampling time to reach the maximum observed analyte plasma concentrationIn situ forming gelsCMC Critical micellar concentrationCmax Maximum observed analyte plasma concentrationIntramuscular injectionDN Dose normalizedGPT Gel point temperaturePLGA Poly-(DL-lactic-co-glycolic acid)TFA Trifluoroacetic acidCAN AcetonitrileATP Adenosine 5′ triphosphateSalt (chemistry)Polyethylene glycolPoloxamerArticlelcsh:Pharmacy and materia medicaPharmacokineticsIn vivoUHPLC Ultra-high performance liquid chromatographyPharmacokineticsAUClast Area under the analyte concentration versus time curve from time zero to the time of the last measurable (non-below quantification level) concentrationEO Ethylene oxideNMP N-methyl-2-pyrrolidoneComputingMethodologies_COMPUTERGRAPHICSAUC∞ Area under the analyte concentration vs time curve from time zero to infinite timeP407 Poloxamer 407In vitro releasePoloxamerCMT Critical micellar temperatureGel erosionIn vitrot1/2 Apparent terminal elimination half-lifechemistryMDR-TB Multi-drug resistant tuberculosisAUC80h Area under the analyte concentration versus time curve from time zero to 80 htlast Sampling time until the last measurable (non-below quantification level) analyte plasma concentrationMRM Multiple reaction monitoringNuclear chemistrySustained releaseInternational Journal of Pharmaceutics: X

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Epidemiology of intra-abdominal infection and sepsis in critically ill patients: "AbSeS", a multinational observational cohort study and ESICM Trials…

2019

Pardo-Oviedo, Juan Mauricio/0000-0003-0084-3449; Lopez-Delgado, Juan Carlos/0000-0003-3324-1129; Corradi, Francesco/0000-0002-5588-2608; De Backer, Daniel/0000-0001-9841-5762; POTA, VINCENZO/0000-0001-9999-3388; Tomescu, Dana/0000-0001-9673-5754; Sabetian, Golnar/0000-0001-8764-2150; Girardis, Massimo/0000-0002-2453-0829; Brazzi, Luca/0000-0001-7059-0622; Leone, Marc/0000-0002-3097-758X; Zabolotskikh, Igor Borisovich/0000-0002-3623-2546; De Lange, Dylan/0000-0002-0191-7270; ALMEKHLAFI, GHALEB A./0000-0002-0323-7025; Elke, Gunnar/0000-0002-4948-1605; Grigoras, Ioana/0000-0001-9412-9574; Czuczwar, Miroslaw/0000-0002-9025-6717; Nora, David/0000-0002-1133-7368; Masjedi, Mansoor/0000-0001-6175-9…

Infection riskMaleBIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences.Antibiotic resistanceTracte gastrointestinal - MalaltiesDefinitionsCritical Care and Intensive Care MedicineTHERAPYDEFINITIONS:Infections::Intraabdominal Infections [DISEASES]0302 clinical medicineIntensive care; Intra-abdominal infection; Mortality; Multidrug resistance; Peritonitis; Sepsis;[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseasesObservational studySeptic shockIntensive care; Intra-abdominal infection; Mortality; Multidrug resistance; Peritonitis; SepsisComputingMilieux_MISCELLANEOUSCritical Illness/epidemiology[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseasesBIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti.Intraabdominal Infections/epidemiologyAbdominal infectionMulticenter study3. Good healthManagementClinical trialCohort[SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/VirologyCohort analysisCommunity acquired infectionCohort studyHumanmedicine.medical_specialtyCarbapenem resistanceCritical IllnessPeritoneal dialysisPeritonitisVancomycin resistant enterococcusMajor clinical studyPeritonitisArticle03 medical and health sciencesAntibiotic resistance[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemIntensive careSepsisSettore MED/41 - ANESTESIOLOGIAHumansCritical care medicineHospital infectionAgedScience & TechnologyLiver failureAntibiotic therapymedicine.disease[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/BacteriologyEpidemiologic Studies030228 respiratory systemIntensive Care Unit; Sepsis (Diptera); Septic ShockRisk factorHuman medicineGeneral & internal medicineCongestive heart failureOriginalMultidrug resistanceCohort StudiesRisk FactorsCause of DeathEpidemiologyPrevalenceMedicine and Health SciencesAbdominal abscessSepsis/epidemiologyMiddle agedAntifungal therapy2. Zero hungerPeritonitiAntibiotic agentBiliary tract infectionIntensive care ; Intra-abdominal infection ; Mortality ; Multidrug resistance ; Peritonitis ; SepsisMiddle Aged:infecciones bacterianas y micosis::infección::infecciones intraabdominales [ENFERMEDADES]PREVALENCE:Infections::Sepsis [DISEASES]:técnicas de investigación::métodos epidemiológicos::características de los estudios epidemiológicos::estudios epidemiológicos::estudios de cohortes [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS]Methicillin resistant staphylococcus aureusRaonament basat en casosFemaleCritically ill patientLife Sciences & BiomedicineAntifungal agentAdult:Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics::Epidemiologic Studies::Cohort Studies [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT]Predictive value:infecciones bacterianas y micosis::infección::sepsis [ENFERMEDADES]NOSepsisIntra-abdominal infectionCritical Care MedicineInternal medicineGeneral & Internal MedicinemedicineMANAGEMENTJournal Article[SDV.MP.PAR]Life Sciences [q-bio]/Microbiology and Parasitology/ParasitologySepticèmiaMortalitybusiness.industrySeptic shockPancreas diseaseMalnutrition030208 emergency & critical care medicineTyphlitisToxic megacolonIntensive careIntraabdominal InfectionsTherapyLate onset disorderbusiness

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Lack of Detrimental Effects of Bacillus thuringiensis Cry Toxins on the Insect Predator Chrysoperla carnea : a Toxicological, Histopathological, and …

2006

ABSTRACT The effect of Cry proteins of Bacillus thuringiensis on the green lacewing ( Chrysoperla carnea ) was studied by using a holistic approach which consisted of independent, complementary experimental strategies. Tritrophic experiments were performed, in which lacewing larvae were fed Helicoverpa armigera larvae reared on Cry1Ac, Cry1Ab, or Cry2Ab toxins. In complementary experiments, a predetermined amount of purified Cry1Ac was directly fed to lacewing larvae. In both experiments no effects on prey utilization or fitness parameters were found. Since binding to the midgut is an indispensable step for toxicity of Cry proteins to known target insects, we hypothesized that specific bind…

InsectanoctuidaeBacterial ToxinsBacillus thuringiensisHelicoverpa armigeraApplied Microbiology and BiotechnologyHemolysin ProteinsBacterial ProteinsBacillus thuringiensisBotanyExiguaInvertebrate MicrobiologyAnimalsBioassaycrystal proteinsPest Control BiologicalChrysoperla carnealarval midgutBacillus thuringiensis ToxinsMicrovilliEcologybiologybinding-sitesfungitoxicityMidgutbiology.organism_classificationspodoptera-exiguaEndotoxinsPRI BioscienceBiochemistryCry1Acmaize expressing cry1abNoctuidaeDigestive Systemborder membrane-vesicleshelicoverpa-armigera lepidopteraFood ScienceBiotechnologyresistant transgenic plants

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Responsive versus Treatment-Resistant Perpetrators in Batterer Intervention Programs: Personal Characteristics and Stages of Change.

2020

This article aims to identify different personal characteristics in treatment-responsive and treatment-resistant perpetrators of intimate partner violence who completed a batterer intervention program (BIP). The sample consists of 105 perpetrators of intimate partner violence who were court-mandated to a community-based cognitive behavioral program. Perpetrators were classified by professionals as resistant or responsive to treatment based on the stage of change they reached upon completion of the program. The results show that before starting the intervention program, treatment-resistant perpetrators scored higher than treatment-responsive perpetrators in external responsibility attributio…

Intervention program05 social sciencesStage of change050109 social psychologyCognitionmedicine.diseasePersonality disordersArticlePathology and Forensic MedicinePsychiatry and Mental healthIntervention (counseling)medicineDomestic violence0501 psychology and cognitive sciencesPsychology (miscellaneous)AttributionPsychologyLawTreatment resistant050104 developmental & child psychologyClinical psychologyPsychiatry, psychology, and law : an interdisciplinary journal of the Australian and New Zealand Association of Psychiatry, Psychology and Law

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Cytotoxicity of Endoperoxides from the Caribbean Sponge Plakortis halichondrioides towards Sensitive and Multidrug-Resistant Leukemia Cells: Acids vs…

2016

The 6-epimer of the plakortide H acid (1), along with the endoperoxides plakortide E (2), plakortin (3), and dihydroplakortin (4) have been isolated from a sample of the Caribbean sponge Plakortis halichondrioides. To perform a comparative study on the cytotoxicity towards the drug-sensitive leukemia CCRF-CEM cell line and its multi-drug resistant subline CEM/ADR5000, the acid of plakortin, namely plakortic acid (5), as well as the esters plakortide E methyl ester (6) and 6-epi-plakortide H (7) were synthesized by hydrolysis and Steglich esterification, respectively. The data obtained showed that the acids (1, 2, 5) exhibited potent cytotoxicity towards both cell lines, whereas the esters s…

LeukemiaCaribbean spongeplakortideEstersAntineoplastic Agents PhytogenicDrug Resistance MultipleArticle570 Life sciencesPoriferaDioxaneslcsh:Biology (General)Caribbean RegionDrug Resistance NeoplasmCell Line TumorPlakortisAnimalsHumanscytotoxicityDrug Screening Assays Antitumorlcsh:QH301-705.5Acidsendoperoxidemulti-drug resistant leukemia570 BiowissenschaftenMarine drugs

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Gallium modulates osteoclastic bone resorption in vitro without affecting osteoblasts.

2010

Gallium (Ga) has been shown to be effective in the treatment of disorders associated with accelerated bone loss, including cancer-related hypercalcemia and Paget's disease. These clinical applications suggest that Ga could reduce bone resorption. However, few studies have studied the effects of Ga on osteoclastic resorption. Here, we have explored the effects of Ga on bone cells in vitro.In different osteoclastic models [osteoclasts isolated from long bones of neonatal rabbits (RBC), murine RAW 264.7 cells and human CD14-positive cells], we have performed resorption activity tests, staining for tartrate resistant acid phosphatase (TRAP), real-time polymerase chain reaction analysis, viabili…

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Etestw versus broth microdilution for ceftaroline MIC determination with Staphylococcus aureus: Results from PREMIUM, a European multicentre study

2017

Objectives: To compare the concordance of ceftaroline MIC values by reference broth microdilution (BMD) and Etest (bioMérieux, France) for MSSA and MRSA isolates obtained from PREMIUM (D372SL00001), a European multicentre study. Methods: Ceftaroline MICs were determined by reference BMD and by Etest for 1242 MSSA and MRSA isolates collected between February and May 2012 from adult patients with community-acquired pneumonia or complicated skin and soft tissue infections; tests were performed across six European laboratories. Selected isolates with ceftaroline resistance in broth (MIC >1 mg/L) were retested in three central laboratories to confirm their behaviour. Results: Overall concordance…

Male0301 basic medicineCephalosporinPharmacologiemedicine.disease_causeCommunity-acquired pneumoniaPneumonia StaphylococcalCommunity-Acquired InfectionPharmacology (medical)Pathologie maladies infectieusesAged 80 and overMicrobial Sensitivity TestBroth microdilutionCeftalorine; Staphylococcus aureus; PREMIUM STUDY GROUPCeftalorineMiddle AgedAnti-Bacterial AgentsCommunity-Acquired InfectionsEuropeInfectious DiseasesStaphylococcus aureusStaphylococcus aureuStaphylococcal Skin InfectionsFemaleHumanAdultMicrobiology (medical)medicine.medical_specialtyStaphylococcus aureusAdolescentmedicine.drug_classCephalosporin030106 microbiologyPREMIUM STUDY GROUPMicrobial Sensitivity TestsStaphylococcal Skin InfectionMicrobiologyYoung Adult03 medical and health sciencesInternal medicineAnti-Bacterial AgentmedicineHumansEtestAgedPharmacologyAdult patientsbusiness.industrybiochemical phenomena metabolism and nutritionmedicine.diseasebacterial infections and mycosesMethicillin-resistant Staphylococcus aureusCephalosporinsMethicillin Susceptible Staphylococcus Aureusbusiness

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Outbreak of IMI-1 Carbapenemase-producing colistin-resistant Enterobacter cloacae on the French island of Mayotte (Indian Ocean)

2018

International audience; The spread of carbapenemase-producing Enterobacteriaceae in the Southwest Indian Ocean islands is poorly known. Here we describe an outbreak of colistin-resistant Enterobacter cloacae harbouring blaIMI-1 in the French overseas department of Mayotte. Between October 2015 and January 2017, all isolates of imipenem-non-susceptible E. cloacae at Mayotte Medical Center and University Hospital of Reunion Island were screened for carbapenemase production. Positive isolates were typed by pulsed-field gel electrophoresis and whole-genome sequencing (WGS)-based multilocus sequence typing (MLST), and all β-lactamase genes were identified by PCR and sequencing. Resistance profil…

Male0301 basic medicineImipenembla(IMI-1)Carbapenem-resistant enterobacteriaceaeComorosDisease Outbreaks[ SDV.MP ] Life Sciences [q-bio]/Microbiology and ParasitologyPharmacology (medical)Enterobacteriaceae InfectionsGeneral MedicineMiddle AgedFrench overseas islandAnti-Bacterial AgentsElectrophoresis Gel Pulsed-Field3. Good healthInfectious Diseases[SDV.MP]Life Sciences [q-bio]/Microbiology and ParasitologyFemalemedicine.drugAdultErtapenemMicrobiology (medical)Adolescent030106 microbiologyMayotteMicrobial Sensitivity TestsBiologybeta-LactamasesMicrobiologyCarbapenemaseYoung Adult03 medical and health sciencesBacterial Proteins[ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathologyEnterobacter cloacaePulsed-field gel electrophoresismedicineHumansEtestColistinOutbreakOutbreakbiology.organism_classificationCephalosporinsImipenemCarbapenem-Resistant EnterobacteriaceaeCarbapenemsColistinMultilocus sequence typingEnterobacter cloacaeGenome BacterialMultilocus Sequence Typing

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Predicting resistant etiology in hospitalized patients with blood cultures positive for Gram-negative bacilli

2018

Abstract Objective To develop a risk-scoring tool to predict multidrug-resistant (MDR) etiology in patients with bloodstream infections (BSI) caused by Gram-negative bacilli (GNB). Methods A prospective multicenter study analyzed patients with BSI hospitalized in 31 Internal Medicine wards in Italy from March 2012 to December 2012. Patients with BSI caused by MDR-GNB (non-susceptible to at least one agent in three antimicrobial categories) were compared to those with BSI due to susceptible GNB. A logistic regression to identify predictive factors of MDR-GNB was performed and the odds ratio (OR) were calculated. A score to predict the risk of MDR was developed. Results Of 533 BSI episodes, 2…

Male0301 basic medicineMultivariate analysisGram-negative bacilliHospitalized patientsLogistic regressionLikelihood ratios in diagnostic testingRisk FactorsDrug Resistance Multiple BacterialMedicineAge FactorMultidrug-resistantProspective StudiesMultivariate AnalysiAged 80 and overAge FactorsAnti-Bacterial AgentsHospitalizationItalyBloodstream infections; Gram-negative bacilli; Multidrug-resistantBloodstream infections; Gram-negative bacilli; Multidrug-resistant; Internal MedicineFemaleSettore SECS-S/01 - StatisticaHumanmedicine.medical_specialtyLogistic Model030106 microbiologyBloodstream infection03 medical and health sciencesInternal medicineAnti-Bacterial AgentGram-Negative BacteriaGram-Negative Bacterial InfectionInternal MedicineHumansAgedbusiness.industryRisk FactorGram negative bacilliOdds ratiomedicine.diseaseProspective StudieLogistic ModelsROC CurveBlood CultureBacteremiaMultivariate AnalysisEtiologyBloodstream infectionsGram-Negative Bacterial Infectionsbusiness

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