Search results for "Resistin"
showing 10 items of 47 documents
Resistin: Insulin resistance to malignancy
2014
Adipose tissue is recognized as an endocrine organ that secretes bioactive substances known as adipokines. Excess adipose tissue and adipose tissue dysfunction lead to dysregulated adipokine production that can contribute to the development of obesity-related co-morbidities. Among the various adipokines, resistin, which was initially considered as a determinant of the emergence of insulin resistance in obesity, has appeared as an important link between obesity and inflammatory processes. Several experimental and clinical studies have suggested an association between increased resistin levels and severe conditions associated with obesity such as cardiovascular disease and malignancies. In th…
A new design problem in the formulation of a special moment resisting connection device for preventing local buckling
2021
In the present paper an improved formulation devoted to the optimal design problem of a special moment resisting connection device for steel frames is proposed. This innovative device is called a Limited Resistance Plastic Device (LRPD) and it has been recently proposed and patented by some of the authors. It is thought to be preferably located at the extremes of the beam, connecting the beam end cross section with the relevant column. The typical device is a steel element characterized by symmetry with respect to three orthogonal barycentric planes and constituted by a sequence of three portions with abrupt cross section changes. The main novelty of the present proposal is related to the d…
Shear design of high strength concrete beams in MRFs
2019
This paper presents the criteria for the shear design of high strength concrete (HSC) beams in moment resisting frames (MRFs). The formulation of an analytical model is provided for the case of beams with longitudinal reinforcement in the presence of transverse stirrups. The model is of additive type, in the meaning that the shear resistance of the beam is evaluated as the sum of several contributions. In particular, the contribution of concrete, longitudinal rebars, and transversal reinforcement are taken into account. Furthermore, for assessing the concrete contribution, a classical approach is followed, according to which two effects arise in the shear mechanism: the arc and the beam eff…
An innovative moment resisting steel connection: optimal design formulations, practical applications and experimental tests
2023
This thesis concerns the study of an innovative moment resisting connection device to be adopted in the so-called moment resisting steel frames. Following previous seismic events, such as Northridge in 1994, many steel structures characterized by welded connections between beams and columns experienced extended damages and diffused brittle failures, making the facilities unserviceable and economically disadvantageous to repair. The answers to this problem is represented by a large number of studies, where several proposals for different devices, as well as special technical solutions, are available. However, the main idea developed among all the proposals is represented by the identificatio…
Visceral adiposity in patients with psoriatic arthritis and psoriasis alone and its relationship with metabolic and cardiovascular risk
2020
Abstract Background Fat mass distribution, especially in the abdominal visceral region, has been rarely evaluated in patients with PsA or psoriasis (PsO). Methods Patients with PsA and patients with PsO alone were evaluated and compared with control subjects (1:1 ratio in each patient group) matched for age, sex and BMI category. Body composition and fat distribution (android and visceral fat) were evaluated by DXA. Anthropometric measurements, disease activity and the systematic coronary risk evaluation (SCORE) cardiovascular risk were assessed. Metabolic parameters (insulin, homeostasis model assessment for insulin resistance), serum adipokines [total and high-molecular-weight adiponectin…
Interactions of the hormones leptin, ghrelin, adiponectin, resistin, and PYY3-36 with the reproductive system.
2006
Objective To summarize the effects of novel hormones (leptin, ghrelin, adiponectin, resistin, and PYY3-36) secreted from adipose tissue and the gastrointestinal tract that have been discovered to exert different effects on several reproductive functions, such as the hypothalamic–pituitary–gonadal axis, embryo development, implantation physiology, and clinically relevant conditions. Design A MEDLINE computer search was performed to identify relevant articles. Result(s) Leptin and ghrelin exert important roles on body weight regulation, eating behavior, and reproduction, acting on the central nervous system and target reproductive organs. As a marker of adequate nutritional stores, these horm…
Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue.
2006
Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid. Many people supplement their diets with CLAs to attempt weight loss, and the trans-10,cis-12 isomer (t10,c12-CLA) of CLA reduces adiposity in animal models and humans. However, CLA treatment in mice causes insulin resistance that has been attributed to the lipoatrophic state, which is associated with hyperinsulinemia and hepatic steatosis. Here, we investigated the effect of t10,c12-CLA on adipose tissue inflammation, another factor promoting insulin resistance. We confirmed that t10,c12-CLA daily gavage performed in mice reduces white adipose tissue (WAT) mass and adiponectin and leptin serum levels and provo…
On the Limit Behaviour of Moment Resisting Connections Under Uncertainties
2021
Abstract Moment resisting connections are mainly designed to transfer bending moments and shear forces. Generally speaking, the design strength of a moment resisting connection can be classified as full-strength (moment capacity of the connection equal to or greater than that of the connected member) or partial-strength (the moment capacity of the connection less than that of the connected member). Similar remarks can be made regarding the stiffness defining connection rigid or semi-rigid if compared to the stiffness of the connected member. In the past, full-strength connections have been widely adopted especially in moment resisting frames and their structural performance relied on the pr…
Metabolic syndrome in the offspring of centenarians: focus on prevalence, components, and adipokines
2013
With aging, an increased prevalence of a clustering of metabolic abnormalities has been observed. These abnormalities include obesity, dyslipidemia, hypertension, and insulin resistance and are collectively known as metabolic syndrome (MetS), a low-grade, systemic, inflammatory condition associated with an increased risk of cardiovascular disease, diabetes, and other adverse health outcomes. A number of studies have demonstrated that centenarians’ offspring have a significant survival advantage and a lower risk of developing the most important age-related diseases. They therefore represent one of the best models with which to study the familiar component of human longevity. The aim of this …
Visceral adiposity index (VAI) is predictive of an altered adipokine profile in patients with type 2 diabetes.
2014
Aims Although there is still no clear definition of “adipose tissue dysfunction” or ATD, the identification of a clinical marker of altered fat distribution and function may provide the needed tools for early identification of a condition of cardiometabolic risk. Our aim was to evaluate the correlations among various anthropometric indices [BMI, Waist Circumference (WC), Hip Circumference (HC), Waist/Hip ratio (WHR), Body Adiposity Index (BAI) and Visceral adiposity Index (VAI)] and several adipocytokines [Visfatin, Resistin, Leptin, Soluble leptin receptors (sOB-R), Adiponectin, Ghrelin, Adipsin, PAI-1, vascular endothelial growth factor (VEGF), Hepatocyte growth factor (HGF) TNF-α, hs-CRP…