Search results for "Respiratory disease"

showing 10 items of 278 documents

Clinical and Biological Heterogeneity in Children with Moderate Asthma

2003

To evaluate the relationship between inflammatory markers and severity of asthma in children, the amount of interleukin-8 (IL-8) and granulocyte/macrophage colony-stimulating factor (GM-CSF) released by peripheral blood mononuclear cells, exhaled nitric oxide (FE NO) levels, p65 nuclear factor-kappaB subunit, and phosphorylated IkBalpha expression by peripheral blood mononuclear cells were assessed in six control subjects, 12 steroid-naives subjects with intermittent asthma, and 17 children with moderate asthma. To investigate their predictive value, biomarker levels were correlated with the number of exacerbations during a 18-month follow-up period. We found that GM-CSF release was higher …

MaleExacerbationAnti-Inflammatory AgentsCritical Care and Intensive Care MedicineSynaptotagminsMedicineChildSalmeterol XinafoateCalcium-Binding ProteinMembrane GlycoproteinsRespiratory diseaseNF-kappa Binflammatory markersBronchodilator AgentsAnti-Inflammatory AgentSynaptotagmin IBiomarker (medicine)FemaleMembrane GlycoproteinAndrostadienes; Anti-Inflammatory Agents; NF-kappa B; Leukocytes Mononuclear; Membrane Glycoproteins; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Synaptotagmins; Albuterol; Asthma; Child; Receptors Cell Surface; Nerve Tissue Proteins; Nitric Oxide; Synaptotagmin I; Calcium-Binding Proteins; Interleukin-8; Adolescent; Bronchodilator Agents; Male; Biological Markers; Femalemedicine.symptomHumanmedicine.drugPulmonary and Respiratory MedicineAdolescentNerve Tissue ProteinsReceptors Cell SurfaceInflammationNitric OxidePeripheral blood mononuclear cellFluticasone propionateHumansAlbuterolBronchodilator AgentAsthmaAndrostadienefluticasone propionatebusiness.industryCalcium-Binding ProteinsInterleukin-8Granulocyte-Macrophage Colony-Stimulating Factormedicine.diseaseSynaptotagminAsthmaAndrostadienesasthma; inflammatory markers; fluticasone propionateNerve Tissue ProteinBiological MarkerExhaled nitric oxideImmunologyLeukocytes MononuclearFluticasonebusinessBiomarkersAmerican Journal of Respiratory and Critical Care Medicine
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Diagnosis of a Pleural Mesothelioma by Endosonography-Guided Transgastric Fine-Needle Aspiration

2001

MaleMesotheliomamedicine.medical_specialtySurgical approachmedicine.diagnostic_testbusiness.industryPleural mesotheliomaPleural NeoplasmsBiopsy NeedleRespiratory diseaseGastroenterologymedicine.diseaseEndosonographyEndoscopyPleural diseaseFatal OutcomeFine-needle aspirationBiopsymedicineHumansRadiologyUltrasonographybusinessUltrasonography InterventionalAgedEndoscopy
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Staphylococcus saprophyticus as an Unusual Agent of Nosocomial Pneumonia

1999

MaleMicrobiology (medical)MicrococcaceaeStaphylococcusPenicillinsPneumonia BacterialmedicineHumansCross InfectionStaphylococcus saprophyticusmedicine.diagnostic_testbiologybusiness.industryRespiratory diseaseMiddle AgedStaphylococcal Infectionsbiology.organism_classificationmedicine.diseasePneumoniaTreatment OutcomeInfectious DiseasesBronchoalveolar lavageLavage bronchoalveolaireLung diseaseInjections IntravenousImmunologybusinessBronchoalveolar Lavage FluidBacteriaClinical Infectious Diseases
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Clinical effects of a Long-term Educational Program for Children with Asthma - Aironet®. A 1-yr randomized controlled trial

2009

Educational self-management programs for children with asthma have now become a routine feature in the management of the disease, as international guidelines underline. We designed this trial to find out whether Aironet, an educational program developed for children with asthma, influenced asthma severity and improved parents' knowledge of the disease. In a multicenter, prospective, randomized controlled trial we enrolled 123 children, 72 boys, mean age 8.78 yr (+/-2.33 s.d.), with intermittent or mild persistent asthma. Participants were randomly assigned to an education group, who received Aironet at baseline and 2 months later (60 children), or to a control group who did not (63 children…

MaleParentsSpirometryHealth Knowledge Attitudes Practicemedicine.medical_specialtyPediatricsHealth BehaviorImmunologyDiseaseSeverity of Illness Indexlaw.inventionPatient Education as TopicRandomized controlled triallawOutpatientsmedicineAnti-Asthmatic AgentHumansImmunology and AllergyAnti-Asthmatic AgentsChildSeverity of Illness Index; Outpatients; Self Care; Humans; Anti-Asthmatic Agents; Asthma; Child; Patient Education as Topic; Health Knowledge Attitudes Practice; Health Behavior; Program Evaluation; Parents; Female; MaleAsthmamedicine.diagnostic_testbusiness.industryRespiratory diseaseOutpatientmedicine.diseaseAsthmaSelf CareEl NiñoParentPediatrics Perinatology and Child HealthPhysical therapyFemaleHealth educationbusinessEducational programHumanProgram EvaluationPediatric Allergy and Immunology
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Differential uptake of systemic fluorochrome Hoechst 33342 in lung and liver metastasis of B16 melanoma.

1992

The growth and vascularization patterns of B16 melanoma colonies in the liver and lungs were measured and compared by histological techniques and dye diffusion patterns after injection of the fluorochrome Hoechst 33342. In the liver, the fluorescent pattern of dye diffusion revealed that uninodular tumours measuring up to 146 microns in diameter were not functionally vascularized. However, when the nodules fused to give rise to multinodular tumours measuring between 256 and 366 microns in diameter, a reticular dye diffusion pattern revealed functional tumour vascularization. In the lungs, subpleural, parenchymal and peritubular (i.e. surrounding blood vessels and airways) tumours were obser…

MalePathologymedicine.medical_specialtyLung NeoplasmsRatónmedicine.medical_treatmentMelanoma ExperimentalBiologyPathology and Forensic MedicineMetastasisMiceParenchymamedicineAnimalsNeoplasm MetastasisMolecular BiologyChemotherapyLungNeovascularization PathologicRespiratory diseaseLiver NeoplasmsCell BiologyGeneral Medicinemedicine.diseaseRadiation therapyMice Inbred C57BLmedicine.anatomical_structureReticular connective tissueBenzimidazolesVirchows Archiv. A, Pathological anatomy and histopathology
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Metastatic hepatocellular carcinoma of the parotid region without lung metastasis: a case report

2009

Parotid gland metastatic tumours are rare, usually arising from a primary mucosal or cutaneous cancer located in the ipsilateral head and neck region, although metastases from a primary cancer outside the head and neck region are possible. Hepatocellular carcinoma (HCC) rarely metastasizes to the head and neck region and the parotid glands are an even more unusual site. The authors describe the case of an 82-year-old male who presented with a right parotid mass. Percutaneous incisional biopsy with histological and immunohistochemical studies suggested metastatic HCC. Radiological investigations excluded other metastatic lesions. This case illustrates the difficulties that may be encountered…

MalePathologymedicine.medical_specialtyPercutaneousCarcinoma HepatocellularLung NeoplasmsLung metastasisDiagnosis Differentialhepatocellular carcinoma/ parotid region/ lung metastasisFatal Outcomestomatognathic systemmedicineHumansAged 80 and overbusiness.industryRespiratory diseaseLiver NeoplasmsCancermedicine.diseaseParotid glandParotid Neoplasmsstomatognathic diseasesParotid Regionmedicine.anatomical_structureOtorhinolaryngologyHepatocellular carcinomaImmunohistochemistrySurgeryOral Surgerybusiness
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Trends in the prevalence of asthma and allergic rhinitis in Italy between 1991 and 2010

2012

The prevalence of asthma increased worldwide until the 1990s, but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma, asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy, in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993; n=6,031); the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000; n=18,873); and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2…

MalePediatricsCross-sectional study95% CI 1.19-1.59) from 1998-2000 to 2007-2010but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthmaAbstract The prevalence of asthma increased worldwide until the 1990stemporal trendsSurveys and QuestionnairesEpidemiologySurveys and QuestionnaireMedicineasthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in ItalyYoung adultrespectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38from 10.1% to 13.9% and from 16.8% to 25.8%education.field_of_studyAllergic rhinitis; Asthma; Epidemiology; Prevalence; Temporal trends; Wheezing;medicine.diagnostic_testSmokingthe median prevalence of current asthmaallergic rhinitis asthma epidemiology prevalence temporal trends wheezingItalyAbstract The prevalence of asthma increased worldwide until the 1990s but since then there has been no clear temporal pattern. The present study aimed to assess time trends in the prevalence of current asthma asthma-like symptoms and allergic rhinitis in Italian adults from 1990 to 2010. The same screening questionnaire was administered by mail or phone to random samples of the general population (age 20-44 yrs) in Italy in the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993; n=6031); the Italian Study on Asthma in Young Adults (ISAYA) (1998-2000; n=18873); and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2010; n=10494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010 the median prevalence of current asthma wheezing and allergic rhinitis increased from 4.1% to 6.6% from 10.1% to 13.9% and from 16.8% to 25.8% respectively. The prevalence of current asthma was stable during the 1990s and increased (relative risk 1.38 95% CI 1.19-1.59) from 1998-2000 to 2007-2010 mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrs asthma prevalence has increased by 38% in parallel with a similar increase in asthma-like symptoms and allergic rhinitis.mainly in subjects who did not report allergic rhinitis. The prevalence of allergic rhinitis has increased continuously since 1991. The asthma epidemic is not over in Italy. During the past 20 yrssymbolsasthma prevalence has increased by 38%FemaleepidemiologyHumanPulmonary and Respiratory MedicineAdult494). Time trends in prevalence were estimated using Poisson regression models in the centres that repeated the survey at different points in time. From 1991 to 2010in parallel with a similar increase in asthma-like symptoms and allergic rhinitismedicine.medical_specialtyRhinitis Allergic PerennialPopulationprevalencethe Italian Study on Asthma in Young Adults (ISAYA) (1998-2000Settore MED/10 - Malattie Dell'Apparato Respiratorio031)and the Gene Environment Interactions in Respiratory Diseases (GEIRD) study (2007-2010Settore MED/01 - Statistica Medicasymbols.namesakeYoung AdultAllergic rhinitiHumansRespiratory soundsPoisson regressioneducationAsthmaRespiratory SoundsCross-Sectional Studieallergic rhinitisbusiness.industrywheezingwheezing and allergic rhinitis increased from 4.1% to 6.6%Rhinitis Allergic Seasonalasthmain the frame of three multicentre studies: the European Community Respiratory Health Survey (ECRHS) (1991-1993medicine.disease873)Cross-Sectional Studiesn=10Relative riskTemporal trendRespiratory Soundn=6n=18business
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Cross-sectional comparison of the characteristics of respiratory allergy in immigrants and Italian children.

2014

Background: Immigrants represent a good epidemiological model to evaluate the relative influence of environmental and inherited factors on the development of allergy. Several studies on allergy in adults have been published, but few data in children are available. We aimed to investigate the differences, between Italian and immigrant children, in clinical characteristics of respiratory allergy. Methods: This was a multicentre cross-sectional study involving children born in Italy from Italian parents and children born either in Italy or abroad from immigrants. Children referred firstly for allergic respiratory disease (rhinitis/asthma), with an ascertained clinical diagnosis and IgE sensiti…

MalePediatricsmedicine.medical_specialtyAllergyAdolescentmedia_common.quotation_subjectImmunologyImmigrationAllergic asthmaEmigrants and ImmigrantsDiseaseEpidemiologyAllergic rhinitimedicineEthnicityRespiratory HypersensitivityImmunology and AllergyHumansGenetic Predisposition to DiseaseChildChildrenmedia_commonAsthmabusiness.industryRespiratory diseaseRespiratory allergyInfantmedicine.diseaseCross-Sectional StudiesItalyClinical diagnosisChild PreschoolPediatrics Perinatology and Child HealthFemalebusinessImmigrantPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
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Paediatric intensive care admissions for respiratory syncytial virus bronchiolitis in France: results of a retrospective survey and evaluation of the…

2012

SUMMARYThe purpose of this study was to describe the characteristics of patients with bronchiolitis admitted to a paediatric intensive care unit (PICU), and to evaluate a national registry of hospitalizations (Programme de Médicalisation des Systèmes d'Information; PMSI) as a potential source of epidemiological data. Of the 49 French PICUs invited to take part in a retrospective survey of children aged <2 years who were hospitalized during the 2005–2006 epidemic season, 24 agreed to participate. Overall, 467 children were enrolled: 75% were aged <2 months, 76% had positive respiratory syncytial virus (RSV) tests, 34·9% required non-invasive ventilation, 36·6% were mechanically ventila…

MalePediatricsmedicine.medical_specialtyDatabases FactualEpidemiologymedicine.medical_treatment[ SDV.MHEP.PED ] Life Sciences [q-bio]/Human health and pathology/PediatricsRespiratory Syncytial Virus InfectionsIntensive Care Units Pediatric03 medical and health sciencesDatabases0302 clinical medicine030225 pediatricsEpidemiologymedicineBronchiolitis ViralHumans030212 general & internal medicineViralFactualRetrospective StudiesMechanical ventilationPediatric[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatricsbusiness.industryMortality rateRespirationRespiratory diseaseInfant NewbornInfantReproducibility of ResultsRetrospective cohort studymedicine.diseaseNewbornRespiration Artificial3. Good healthRespiratory Syncytial VirusesHospitalizationIntensive Care UnitsInfectious DiseasesBronchopulmonary dysplasiaBronchiolitisArtificialBreathingBronchiolitisFemaleFrancebusiness
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Nosocomial infection: A risk factor for a complicated course in children with respiratory syncytial virus infection – Results from a prospective mult…

2008

BACKGROUND: Nosocomially acquired respiratory syncytial virus infections (RSV-NI) may cause serious problems in hospitalized paediatric patients. Hitherto, prospectively collected representative data on RSV-NI from multicenter studies in Germany are limited. METHODS: The DMS RSV Ped database was designed for the prospective multicenter documentation and analysis of clinically relevant aspects of the management of inpatients with RSV-infection. The study covered six consecutive seasons (1999-2005); the surveillance took place in 14 paediatric hospitals in Germany. RESULTS: Of the 1568 prospectively documented RSV-infections, 6% (n=90) were NI and 94% (n=1478) were community acquired (CA). A …

MalePediatricsmedicine.medical_specialtyDatabases FactualHeart diseasemedicine.medical_treatmentRespiratory Syncytial Virus InfectionsSeverity of Illness IndexRisk FactorsGermanyNasopharynxSeverity of illnessmedicineHumansProspective StudiesRisk factorProspective cohort studyMechanical ventilationCross Infectionbusiness.industryRespiratory diseaseInfant NewbornPublic Health Environmental and Occupational HealthInfantHospitals Pediatricmedicine.diseaseRespiratory Syncytial VirusesCommunity-Acquired InfectionsPopulation SurveillanceRegression AnalysisFemaleViral diseaseComplicationbusinessInfant PrematureInternational Journal of Hygiene and Environmental Health
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