Search results for "Retinal"

The role of glia, mitochondria, and the immune system in glaucoma.

2009

Author(s): Tezel, Gulgun; Fourth ARVO/Pfizer Ophthalmics Research Institute Conference Working Group

Plasma gangliosides and age-related macular degeneration

2013

Purpose Age-related macular degeneration (AMD) is a multifactorial and polygenic disease and is the main cause of vision loss in developed countries after 50 years old. Indeed, dry AMD leads to progressive retinal atrophy and exsudative AMD induces a rapid alteration of the macula through neovascularisation. Gangliosides (GG) make a wide and heterogeneous family of sialic-acid-containing glycosphingolipids, composed of a sugar chain branched on a ceramide. They are major components of cellular membranes and are particularly abundant in the brain and nervous tissue, including retina. They are also found circulating in the plasma. GG are known for their neuroprotective properties in the nervo…

Time response of the vision binocularity by use of dynamic suppression of retinal images

1999

We present a novel technique for determination the stereopsis dynamic response, using as stimulus a random dot stereopair. Stereopsis can be evoked or depressed by continuous or flash illumination of the stimulus with simultaneous control of a special light scattering obstacle build in the visual path of one eye. The obstacle--a thin plate of electrooptical PLZT ceramics-- exposes (by applying of the voltage to semitransparent gold electrodes deposited on both surfaces of the plate) light scattering so blurring the retinal image, similar as for an eye with a cataract, depressing stereopsis. The random dot stereopair contains contours of images with a different stereodisparity. The PLZT plat…

Optical coherence tomography in congenital hypertrophy of the retinal pigment epithelium.

2014

CONVENTIONAL INTERNAL LIMITING MEMBRANE PEELING VERSUS INVERTED FLAP FOR SMALL-TO-MEDIUM IDIOPATHIC MACULAR HOLE

2022

Purpose: To compare conventional internal limiting membrane (ILM) peeling versus inverted flap technique in small-to-medium idiopathic macular hole. Methods: Eyes with ≤400 μ m idiopathic macular holes were randomized into the conventional ILM peeling group (25 eyes) and inverted flap group (25 eyes). A 12-month follow-up was considered. Macular sensitivity (MS) change detected with MP-1 microperimetry was the primary outcome. Secondary outcomes included best-corrected visual acuity change, closure rate, anatomical findings on optical coherence tomography such as U-shape foveal contour, restoration of external limiting membrane, and ellipsoid zone. Results: In both groups, MS improved throu…

Peripapillary Staphyloma and Asymmetric Morning Glory Anomaly

2006

We report a patient with concomitant occurrence of peripapillary staphyloma and morning glory anomaly. The morning glory anomaly presented with an optic nerve head with oblique entrance, located on one side of the peripapillary staphyloma, giving an unusually asymmetric and previously undescribed appearance to the abnormality. The optical coherence tomography provided useful information about the shape and deepness of the peripapillary staphyloma and disclosed a retinal detachment not appreciated ophthalmoscopically.

Incidence of retinal artery occlusion in Germany

2020

Vitrektomie und Membrane Peeling epiretinaler Gliosen nach konservativer Amotiochirurgie

2001

Ziel Die Prufung der Effizienz der Macular—pucker Chirurgie bei sekundaren Gliosen nach Plombenversorgung rhegmatogener Netzhautablosungen.

VAMPIRE: Vessel assessment and measurement platform for images of the REtina

2011

We present VAMPIRE, a software application for efficient, semi-automatic quantification of retinal vessel properties with large collections of fundus camera images. VAMPIRE is also an international collaborative project of four image processing groups and five clinical centres. The system provides automatic detection of retinal landmarks (optic disc, vasculature), and quantifies key parameters used frequently in investigative studies: vessel width, vessel branching coefficients, and tortuosity. The ultimate vision is to make VAMPIRE available as a public tool, to support quantification and analysis of large collections of fundus camera images.

Human brain organoids assemble functionally integrated bilateral optic vesicles

2021

During embryogenesis, optic vesicles develop from the diencephalon via a multistep process of organogenesis. Using induced pluripotent stem cell (iPSC)-derived human brain organoids, we attempted to simplify the complexities and demonstrate formation of forebrain-associated bilateral optic vesicles, cellular diversity, and functionality. Around day 30, brain organoids attempt to assemble optic vesicles, which develop progressively as visible structures within 60 days. These optic vesicle-containing brain organoids (OVB-organoids) constitute a developing optic vesicle's cellular components, including primitive corneal epithelial and lens-like cells, retinal pigment epithelia, retinal progeni…