Search results for "Retinopathy"

Tīklenes attēlu analīze diabētiskās retinopātijas radīto tīklenes izmaiņu detektēšanai

2022

Bakalaura darbs ir uzrakstīts angļu valodā uz 42 lappusēm. Tas satur 32 attēlus, 2 tabulas un 59 atsauces uz literatūras avotiem. Darba mērķis bija pārbaudīt, vai pastāv atšķirība starp vidējo pikseļu intensitāti fundusa attēlā, kurā redzama vesela tīklene, un attēlu ar diabētisku retinopātiju. Attēli tika ņemti no divām datu bāzēm, kurās kopumā bija 127 attēli bez patologijam un 129 attēli ar diabētiskās retinopātijas klātbūtni. Attēlu analīzei tika izmantota programma MATLAB. Pētījuma rezultāti parādīja, ka zilajam kanālam ir būtiska atšķirība, bet sarkanajam un zaļajam kanālam nav. Ir jāveic vairāk pētījumu, lai secinātu, vai ir būtiskas atšķirības pikseļu intensitātē veseliem un diabēti…

The Narrative Medicine Approach in the Treatment of Diabetic Macular Edema: An Italian Experience.

2022

The study retraces the healthcare pathway of patients affected by diabetic macular edema (DME) through the direct voice of patients and caregivers by using a “patient journey” and narrative method approach. The mapping of the patient’s journey was developed by a multidisciplinary board of health professionals and involved four Italian retina centers. DME patients on intravitreal injection therapy and caregivers were interviewed according to the narrative medicine approach. Narratives were analyzed through a quali-quantitative tool, as set by the narrative medicine method. The study involved four specialized retina centers in Italy and collected a total of 106 narratives, 8…

Axial Length and Anterior Segment Alterations in Former Preterm Infants and Full-Term Neonates Analyzed With Scheimpflug Imaging.

2017

Purpose To compare the axial length and anterior segment alterations in preterm infants with and without retinopathy of prematurity with those of full-term infants. Methods The Wiesbaden Prematurity Study investigated 503 participants of former gestational age ≤32 weeks and gestational age ≥37 weeks now being aged 4 to 10 years. This study included 485 participants in the prospective controlled cross-sectional, hospital-based study with successful Pentacam Scheimpflug imaging. Anterior segment parameters, axial length measurements, and associated factors were analyzed. Results Corneal thickness did not differ between former preterm and full-term infants. Significant differences were found b…

Intraoperative dexamethasone intravitreal implant in diabetic macular edema patients undergoing phacoemulsification: The CataDex study

2021

Purpose To assess the impact of preoperative intravitreal dexamethasone implant (DexI) on functional and anatomic outcomes in patients with diabetic macular edema (DME) who underwent phacoemulsification cataract surgery. Methods Prospective and non-comparative study conducted on consecutive DME patients undergoing cataract surgery. DexI was administered 15 days before surgery and in a pro re nata regime after surgery. Main outcome measures were mean change in central retinal thickness (CRT), central subfield thickness (CST), total macular volume (TMV), and central subfield volume (CSV) from baseline to month-12. Secondary outcome was mean change in best corrected visual acuity (BCVA). Resul…

Statistical atlas based exudate segmentation

2013

Diabetic macular edema (DME) is characterized by hard exudates. In this article, we propose a novel statistical atlas based method for segmentation of such exudates. Any test fundus image is first warped on the atlas co-ordinate and then a distance map is obtained with the mean atlas image. This leaves behind the candidate lesions. Post-processing schemes are introduced for final segmentation of the exudate. Experiments with the publicly available HEI-MED data-set shows good performance of the method. A lesion localization fraction of 82.5% at 35% of non-lesion localization fraction on the FROC curve is obtained. The method is also compared to few most recent reference methods.

Tilted discs and central retinal vein occlusion.

1993

Automated fundus images analysis techniques to screen retinal diseases in diabetic patients

2011

In this Ph.D. thesis, we study new methods to analyse digital fundus images of diabetic patients. In particular, we concentrate on the development of the algorithmic components of an automatic screening system for diabetic retinopathy. The techniques developed can be categorized in: quality assessment and improvement, lesion segmentation and diagnosis. For the first category, we present a fast algorithm to numerically estimate the quality of a single image by employing vasculature and colour-based features; additionally, we show how it is possible to increase the image quality and remove reflection artefacts by merging information gathered in multiple fundus images (which are captured by ch…

Estudio de factores asociados con amputación, en pacientes diabéticos con ulceración en pie

2001

Objetivo: Analizar factores asociados con amputación en pacientes diabéticos que presentan úlceras en sus pies, con el fin de identificar sujetos con alto riesgo para amputación. Método: Hemos estudiado 152 diabéticos que acudieron a la Unidad del pie diabético desde enero de 1996 hasta junio de 1998 con úlceraciones en sus pies. En 14 de ellos fue necesaria la amputación. Se excluyeron sujetos con gangrena. Resultados: Los factores asociados con amputación fueron: antecedentes personales de amputación previa (odds ratio 3,7; 1,01-13,7), retinopatía proliferativa, osteomielitis y, de forma independiente, la presencia de vasculopatía (7,1; 1,88-27,2) e infección grave (14,4; 2,92-71,2). Conc…

Mutation screening of USH3 gene (clarin-1) in Spanish patients with Usher syndrome: low prevalence and phenotypic variability

2004

Usher syndrome type III is an autosomal recessive disorder clinically characterized by the association of retinitis pigmentosa (RP), variable presence of vestibular dysfunction and progressive hearing loss, being the progression of the hearing impairment the critical parameter classically used to distinguish this form from Usher syndrome type I and Usher syndrome type II. Usher syndrome type III clinical subtype is the rarest form of Usher syndrome in Spain, accounting only for 6% of all Usher syndrome Spanish cases. The gene responsible for Usher syndrome type III is named clarin-1 and it is thought to be involved in hair cell and photoreceptor cell synapses. Here, we report a screening fo…

Oxidative stress and its downstream signaling in aging eyes

2014

María Dolores Pinazo-Durán,1,* Roberto Gallego-Pinazo,2,* Jose Javier García-Medina,1,3,* Vicente Zanón-Moreno,1,4 Carlo Nucci,5 Rosa Dolz-Marco,2 Sebastián Martínez-Castillo,2 Carmen Galbis-Estrada,1 Carla Marco-Ramírez,1 Maria Isabel López-Gálvez,6,* David J Galarreta,6,* Manuel Díaz-Llópis4,*1Ophthalmic Research Unit "Santiago Grisolía", Valencia, Spain; 2Department of Ophthalmology, Macula Section, The University and Polytechnic Hospital La Fe, Valencia, Spain; 3Department of Ophthalmology, University Hospital Reina Sofia, Murcia, Spain; 4Faculty of Medicine, University of Valencia, Spain; 5Uni…