Search results for "Reto"
showing 10 items of 896 documents
Organelle pH studies using targeted avidin and fluorescein–biotin
2000
Abstract Background: Mammalian organelles of the secretory pathway are of differing pH. The pH values form a decreasing gradient: the endoplasmic reticulum (ER) is nearly neutral, the Golgi is mildly acidic and the secretory granules are more acidic still (∼pH 5). The mechanisms that regulate pH in these organelles are still unknown. Results: Using a novel method, we tested whether differences in H + ‘leak' and/or counterion conductances contributed to the pH difference between two secretory pathway organelles. A pH-sensitive, membrane-permeable fluorescein–biotin was targeted to endoplasmic-reticulum- and Golgi-localized avidin-chimera proteins in HeLa cells. In live, intact cells, ER pH (…
Dalla parte dell'ascoltatore. Un approccio pragma-retorico alla comprensione
2019
L’intento principale del saggio è mostrare quanto possa essere vantaggioso guardare al fenomeno della comprensione linguistica utilizzando l’apparato concettuale della retorica classica, messo in fruttuoso dialogo con la pragmatica contemporanea. La legittimità di tale operazione si fonda sulla convinzione che sia proficuo estendere lo specifico punto di vista della retorica al discorso ordinario nel suo complesso. Tale estensione non implica in alcun modo negare la specificità del punto di vista retorico sul linguaggio ma mira anzi a sfruttarla, per fare emergere aspetti altrimenti poco valorizzati. È vero, infatti, che la retorica si occupa tradizionalmente di un tipo particolare di disco…
V I G — A Visual and Dynamic Decision Support System for Multiple Objective Linear Programming
1989
In this paper we describe the principles of VIG (Visual Interactive Goal Programming), a Multiple Criteria Decision Support System, recently developed by Korhonen. PARETO RACE is a corner-stone of this system, which is designed to support both the modelling and solving of a multiple objective linear programming problem. The interface is based on one main menu, spreadsheets, and interactive use of computer graphics. VIG provides the decision-maker with the possibility to approach his/her decision problem by using an “evolutionary approach”. This means that the decision-maker does not have to specify the model precisely prior to solving the problem. In fact, the model evolves progressively. W…
Costruzioni discorsive sull’Europa e sui rapporti tra continenti nell’antichità greca
2019
L’articolo studia le retoriche cui sono state sottoposte le identità rappresentate dai continenti. Viene mostrato così che la mitica parentela originaria ha dato luogo ora ad un legame di solidarietà tra i popoli che occupano l’una o l’altra zona geografica, ora ad una giustificazione delle pretese imperialistiche di un popolo su un altro. Si mostra altresì che i confini tra i continenti vengono presentati, a seconda del punto di vista difensivo o aggressivo da cui se ne parla, ora come segni di una ‘architettura’ naturale di cui si pretende il rispetto, ora come ostacoli da superare in nome dell’amore della conoscenza che vuole esplorare l’ignoto o dell’addomesticamento di ciò che è selvag…
Διαλεκτικές κατασκευές για την Ευρώπη και για τις σχέσεις ανάμεσα σε ηπείρους στην ελληνική αρχαιότητα
2020
L’articolo studia le retoriche cui sono state sottoposte le identità rappresentate dai continenti. Viene mostrato così che la mitica parentela originaria ha dato luogo ora ad un legame di solidarietà tra i popoli che occupano l’una o l’altra zona geografica, ora ad una giustificazione delle pretese imperialistiche di un popolo su un altro. Si mostra altresì che i confini tra i continenti vengono presentati, a seconda del punto di vista difensivo o aggressivo da cui se ne parla, ora come segni di una ‘architettura’ naturale di cui si pretende il rispetto, ora come ostacoli da superare in nome dell’amore della conoscenza che vuole esplorare l’ignoto o dell’addomesticamento di ciò che è selvag…
On the Extension of the DIRECT Algorithm to Multiple Objectives
2020
AbstractDeterministic global optimization algorithms like Piyavskii–Shubert, direct, ego and many more, have a recognized standing, for problems with many local optima. Although many single objective optimization algorithms have been extended to multiple objectives, completely deterministic algorithms for nonlinear problems with guarantees of convergence to global Pareto optimality are still missing. For instance, deterministic algorithms usually make use of some form of scalarization, which may lead to incomplete representations of the Pareto optimal set. Thus, all global Pareto optima may not be obtained, especially in nonconvex cases. On the other hand, algorithms attempting to produce r…
Los combates por la fe y el nacimiento de Europa: El ejemplo español del siglo xv al xvii
2019
Este artículo analiza el efecto que la coexistencia del cristianismo, el judaísmo y el islam ha tenido para la configuración de Europa. El trabajo parte de la España del siglo xv, donde esa convivencia es más evidente, para ilustrar cómo las apologías confesionales solían acabar en la conclusión de que la religión del otro era irracional, resultando, pues, imposible construir una identidad europea sin la aniquilación del otro. Conscientes de ello, humanistas como J. L. Vives prefirieron centrar el acercamiento al otro en lo epistemológico y en lo moral más que en lo dogmático. Ese sería el punto de partida para una Europa como la testimoniada en el Quijote, en la que las racionalidades enfr…
Sekretorā IgA un zarnu mikrobioma mijiedarbība un dinamika antidiabētiskās terapijas laikā
2022
Metformīns ir viens no visplašāk izmantotajiem medikamentiem 2.tipa cukura diabēta (T2D) ārstēšanā. Papildus glikozes izdales samazināšanai aknās un glikozes uzņemšanas palielināšanai muskuļos, arvien vairāk pierādījumu liecina, ka zarnu mikrobioms ir metformīna galvenā darbības vieta. Jaunākie pētījumi liecina, ka metformīns būtiski maina zarnu mikrobiomu T2D pacientiem. Sekretorajam IgA ir svarīga loma zarnu, elpceļu un uroģenitālās gļotādas epitēlija aizsardzībā un homeostatiskā regulēšanā, kā arī mijiedarbībā ar mikrobiomu. Metformīna terapijas laikā tika ievākti fēču paraugi no 19 jaundiagnosticētiem T2D pacientiem (trīs laika punktos) un astoņām veselām kontrolēm (divos laika punktos)…
Performing ‘us’ and ‘other’ : Intersectional analyses of right-wing populist media
2020
Finland and Sweden share the ideal of a Nordic welfare state, with gender equality as a central tenet. In both countries, right-wing populist parties have gained prominence in mainstream politics. Despite similar political agendas at the moment, these parties have different political histories, and different modes of expressing their anti-immigration pleas. In this comparative study, we examine how the distinction between ‘us’ and the ‘other’ is performed intersectionally in terms of gender, social class, ethnicity and ‘race’, and sexuality. For this purpose, we examine empirical material collected from the party newspapers of the Finns Party and the Sweden Democrats, because their content…
Rhetoric of academic applications : Perspectives from Quentin Skinner’s Forensic Shakespeare
2019
The tools of classical and Renaissance rhetoric that Quentin Skinner uses in his Forensic Shakespeare (2014) are here applied to a contemporary context. Skinner’s discussion might have a fairly direct value for a genre of writing that most academics today must master, namely the rhetoric of applications. They have been seldom discussed from a rhetorical perspective, although knowledge of rhetoric is highly valuable for applicants, evaluators and those deciding between applications. Skinner’s book contains both advices for applicants and discussions on both the criteria of application and the possibilities of their revisions in case of innovative applications. peerReviewed