Search results for "Reto"

Recensione a Francesco Robortello. Réception des Anciens et construction de la modernité, sous la direction de M. Bouquet, S. Cappello, C. Lesage et …

2021

Recensione a Francesco Robortello. Réception des Anciens et construction de la modernité, sous la direction de M. Bouquet, S. Cappello, C. Lesage et M. Magnien, Rennes, Presses Universitaires de Rennes, 2020, pp. 508. Il volume accoglie gli atti del Colloquio Internazionale dedicato all’umanista friulano Francesco Robortello (1516-1567), svoltosi a Rennes fra il 6 e l’8 ottobre 2016. Apparso nel 2020, a quattro anni di distanza dalla sua celebrazione, il volume comprende complessivamente 23 interventi di studiosi francesi, italiani, tedeschi e statunitensi – tutti pubblicati in lingua francese, a eccezione di cinque in italiano. Review to Francesco Robortello. Réception des Anciens et const…

Integrismo político en EEUU / 3. El peligro hispano

2004

Sorting of a secretory protein (gp80) to the apical surface of Caco-2 cells

1994

We have investigated the synthesis and polarized secretion of the exogenous gp80 glycoprotein complex in the human epithelial adenocarcinoma cell line, Caco-2. gp80 is secreted at the apical surface of Madin-Darby canine kidney (MDCK) cells and should, therefore, display the signal(s) required for sorting into the apical exocytic pathway. In Caco-2 cells, no bona fide secretory protein released preferentially at the apical surface has been described so far. To address the question of whether Caco-2 cells possess a machinery capable of delivery of secretory proteins at the apical surface, we stably transfected the cells with a recombinant gene coding for the gp80 glycoprotein complex. Pulse-…

"NO HAY VIRTUD SIN EXPERIENCIA": PRETENDIENTES INESPERADOS Y DAMAS AL ACECHO EN LA TRAGEDIA DEL SIGLO DE ORO // NÃO HÁ VIRTUDE SEM EXPERIÊNCIA: PRETE…

2016

RECEBIDO EM 31 AGO 2016 APROVADO EM 01 OUT 2016 A figura do antagonista e chave em qualquer conflito tragico, dado que representa a oposicao a ordem estabelecida, a personagem que consegue develar o lado obscuro do heroi. Um dos conflitos prediletos da tragedia espanhola do seculo XVII e aquele em que se enfrentam o amor e o honor , o passado e o presente, o dever e o desejo, e pode ser articulado por meio de uma estrutura tipificada: um casamento concertado cuja aparente harmonia ver-se-a irremissivelmente alterada pela chegada inesperada de um antigo pretendente da esposa que reclama direitos sentimentais e cuja atuacao comprometedora, unida aos erros da protagonista, levara o marido - in…

« The “Ground-Floor” Maiden Lady. Fanny Lebreton, George Gissing and Salomon Reinach »

2012

International audience

LRP1 modulates APP trafficking along early compartments of the secretory pathway

2008

The amyloid beta peptide (A beta) is a central player in Alzheimer's disease (AD) pathology. A beta liberation depends on APP cleavage by beta- and gamma-secretases. The low density lipoprotein receptor related protein 1 (LRP1) was shown to mediate APP processing at multiple steps. Newly synthesized LRP1 can interact with APP, implying an interaction between these two proteins early in the secretory pathway. We wanted to investigate whether LRP1 mediates APP trafficking along the secretory pathway, and, if so, whether it affects APP processing. Indeed, the early trafficking of APP within the secretory pathway is strongly influenced by its interaction with the C-terminal domain of LRP1. The …

A role for the immunoglobulin-like domain of the human IL-6 receptor. Intracellular protein transport and shedding.

1999

Interleukin (IL)-6, IL-11 and cililary neurotrophic factor (CNTF) belong to the same family of hematopoietic and neurotrophic cytokines. Their receptor complexes contain a cytokine-binding alpha receptor and the common glycoprotein (gp)130 subunit for signal transduction. The extracellular parts of the alpha-receptor subunits consist of a membrane-proximal cytokine-binding domain and an N-terminal immunoglobulin (Ig)-like domain with unknown function. We examined the role of the Ig-like domain of IL-6R by constructing deletion mutants lacking the Ig domain (IL-6RDeltaIg and soluble IL-6RDeltaIg). IL-6RDeltaIg was shed as effectively as wild-type IL-6R from transfected COS-7 cells upon 4beta…

Retention mechanisms for ER and Golgi membrane proteins

2014

Unless there are mechanisms to selectively retain membrane proteins in the endoplasmic reticulum (ER) or in the Golgi apparatus, they automatically proceed downstream to the plasma or vacuole membranes. Two types of coat protein complex I (COPI)-interacting motifs in the cytosolic tails of membrane proteins seem to facilitate membrane retention in the early secretory pathway of plants: a dilysine (KKXX) motif (which is typical of p24 proteins) for the ER and a KXE/D motif (which occurs in the Arabidopsis endomembrane protein EMP12) for the Golgi apparatus. The KXE/D motif is highly conserved in all eukaryotic EMPs and is additionally present in hundreds of other proteins of unknown subcellu…

Kocioł Ezechiela (Ez 24,1-14) w świetle retoryki hebrajskiej

2021

Kontekstem badań było to, że niektórzy komentatorzy proponują różne struktury badanego tekstu. Celem badań stało się opracowanie struktury, którą zamieścił w tekście starożytny autor natchniony. Do tego posłużyła metoda retoryki hebrajskiej, którą opracował Roland Meynet. Udało się odkryć strukturę badanego tekstu. Jest to konstrukcja paralelna o schemacie: A (w. 1a) – B (w. 4ab) – C (w. 6b) – C’ (w. 9b) – B’ (w. 11abc) – A’ (w. 14a). Wnioski: obraz Boga, jaki wyłania się z Księgi Ezechiela, to Bóg Wszechmogący. Bóg Izraela może wszystko uczynić, nawet Nabuchodonozora uczynić narzędziem karania zarówno Izraela, jak i Egiptu. Ponadto należy nadal prowadzić badania nad retoryką hebrajską w Ks…

Deletions in the hepatitis B virus small envelope protein: effect on assembly and secretion of surface antigen particles

1992

The small envelope S protein of hepatitis B virus carrying the surface antigen has the unique property of mobilizing cellular lipids into empty envelope particles which are secreted from mammalian cells. We studied the biogenesis of such particles using site-directed mutagenesis. In this study, we describe the effect of deletions in the N-terminal hydrophobic and hydrophilic domains of the S protein. Whereas short overlapping deletions of hydrophilic sequences flanking the first hydrophobic domain were tolerated, larger deletions of the same sequences were not. Conversely, the hydrophilic region preceding the second hydrophobic domain was not permissive for even short deletions. Deletion of…