Search results for "Retreatment"
showing 10 items of 79 documents
Refining sorafenib therapy: lessons from clinical practice
2015
ABSTRACT Understanding the best use of sorafenib is essential in order to maximize clinical benefit in hepatocellular carcinoma. Based on Phase III and noninterventional study data, as well as our extensive experience, we discuss dose modification in order to manage adverse events, disease response evaluation and how to maximize treatment benefit. Sorafenib should be initiated at the approved dose (400 mg twice daily) and reduced/interrupted as appropriate in order to manage adverse events. Dose modification should be considered before discontinuation. Appropriate tumor response assessment is critical. Focusing on radiologic response may result in premature sorafenib discontinuation; symp…
Assessment of Postharvest Dehydration Kinetics and Skin Mechanical Properties of “Muscat of Alexandria” Grapes by Response Surface Methodology
2016
The dipping of berries in a dilute solution of sodium hydroxide during a short time was evaluated as pretreatment undertaken prior to convective dehydration of wine grapes. The impact of the sodium hydroxide content and dipping time on weight loss (WL) at different dehydration times was thoroughly assessed using central composite design (CCD) and response surface methodology (RSM). Furthermore, the effects of these two variables were also investigated on the skin mechanical properties of dehydrated grapes. The effect of these two pretreatment factors on the dehydration kinetics and skin hardness was satisfactorily fitted to regression models. The berry pretreatment with low sodium hydroxide…
Cryopreservation of Limonium serotinum apical meristems from in vitro plantlets using droplet-vitrification
2011
Abstract In this study in vitro shoot tips of a Sicilian genotype of Limonium serotinum were successfully cryopreserved using the droplet-vitrification technique. Growth recovery of cryopreserved shoot tips was possible only when samples were pretreated for 16 h in liquid medium with 0.3 M sucrose, then for 5 h in liquid medium with 0.7 M sucrose before performing the cryopreservation protocol. Optimal conditions included treatment for 20 min in a loading solution containing 1.9 M glycerol + 0.5 M sucrose, treatment with vitrification solution B5 (glycerol 40.0%, sucrose 40.0%, w/v) for 60 and 90 min or vitrification solution A9 (glycerol 30.0%, dimethylsulfoxide 20.0%, ethylene glycol 20.0…
Prophylaxis of hemicrania continua: two new cases effectively treated with topiramate.
2007
Hemicrania continua (HC) is an uncommon and under-recognized primary headache disorder characterized by a strictly unilateral continuous headache of moderate intensity with possible exacerbations and associated with ipsilateral autonomic features. HC has generally a prompt and enduring response to indomethacin although 25% to 50% of treated patients develop gastrointestinal side effects. These cases pose a difficult management challenge as no other drug is consistently effective in HC. Recently 2 HC patients responsive to topiramate treatment have been reported. Here we describe 2 more patients effectively treated with topiramate. Neither reported any side effects and one had persisting res…
Non-surgical endodontics in retreatment of periapical lesions: two representative case reports
2012
This article reports non-surgical endodontic retreatment of two patients with persistent or recurrent periapical lesions, who had previously undergone surgical and non-surgical endodontic therapy respectively. It further discusses and reviews the relevance of classification of periapical lesions, the explanation behind healing of periapical lesions by endodontic therapy alone, causes of persistence of periapical lesions, choice of treatment modalities (whether surgical or non – surgical) and materials such as intracanal medicaments and irrigants for optimal healing. Key words:Non-surgical, retreatment, periapical, calcium hydroxide, chlorhexidine irrigation.
Ligninolytic potential of Curvularia kusanoi L7 laccases for animal production
2020
The present research was conducted with the objective of evaluating the ligninolytic potential of Curvularia kusanoi L7 laccases in improving the nutritional quality of fibrous substrates for animal feed. Laccase production was obtained from C. kusanoi L7 under native conditions by solid submerged fermentation of wheat bran and by biological interactions with Trichoderma viride M5-2 and Trichoderma pleuroticola. The enzymes were purified from the culture broths by triphasic partition. The degradative potential of native and induced laccases where evaluated by determining foliar lignololytic capacity, raw wheat (Triticum aestivum) straw delignification and the effect of enzyme pretreatment o…
Semi-Continuous Lab-scale Plant for Hydrothermal or Organosolv Treatment of Lignocellulosic Biomass
2013
Lignocellulosic biomass is increasingly being considered as a potential alternative source for both fuels and goods production. In order to better address the starting material to higher conversion and selectivity in the desired products, the possibility to selectively control the dissolution of the three main constituents of the matrix (hemicellulose, cellulose and lignin) should be pursued. As the three biopolymers are intimately connected one another, a suitable pretreatment step could help the effectiveness of the whole process, by producing cleavage of the biomacromolecules interconnecting bonds and by starting their depolymerization . In this frame, we developed a semi-continuous lab-…
Contractile Reserve and Extent of Transmural Necrosis in the Setting of Myocardial Stunning: Comparison at Cardiac MR Imaging
2010
To perform a comparison of cardiac magnetic resonance (MR) imaging-derived ejection fraction (EF) during low-dose dobutamine infusion (EF(D)) with the extent of segments with transmural necrosis in more than 50% of their wall thickness (ETN) for the prediction of major adverse cardiac events (MACEs) and late systolic recovery soon after a first ST-segment elevation myocardial infarction (STEMI).Institutional ethics committee approval and written informed consent were obtained. One hundred nineteen consecutive patients with a first STEMI, a depressed left ventricular EF, and an open infarct-related artery underwent MR imaging at 1 week after infarction. EF(D) and ETN (by using a 17-segment m…
Effect of sodium borohydride and hydrogen peroxide pretreatments on soda pulping of sugar maple (Acer saccharum)
2021
For recovering value-added wood-based organic material prior to delignification, sodium borohydride (NaBH4) and hydrogen peroxide (H2O2) pretreatments under alkaline conditions were performed before soda pulping of sugar maple (Acer saccharum) chips with sodium hydroxide (NaOH). In this investigation, it was determined whether the pulp yield could be increased by partly stabilizing the hemicelluloses by these pretreatments, and simultaneously obtains lower pulp kappa numbers. The results indicated that when aiming to the same kappa numbers (i.e., kappa numbers 14.3-20.5), roughly 3% higher pulp yield could be achieved if the chips were pretreated with alkaline 0.5% NaBH4 solutions, compared…
Electrochemistry of methylene blue at an alkanethiol modified electrode
2012
International audience; Gold surfaces were derivatized with decanethiol. The electrochemistry of methylene blue at these modified electrodes was investigated in function of the gold cleaning process and compared with the results obtained at a bare gold electrode. Cyclic voltammetry at low methylene blue concentrations (c(MB) <= 16 mu M) yielded surface behavior data. The properties of the film vary with the electrode pretreatment. Without electrochemical cleaning step, the standard potential at a gold electrode modified with 1-decanethiol is nearly the same as on a bare gold electrode. On the other hand, when the electrode is electrochemically cleaned before adsorption of the alkanethiols, …