Search results for "Rini"

Chromatographic Air Analyzer Microsystem for the Selective and Sensitive Detection of Explosive-related Compounds

2014

Abstract The detection of explosives and explosive-related compounds is of major importance for the monitoring of explosive- contaminated sites. Current methods need to become cheaper and portable while maintaining a high sensitivity and selectivity level. In that sense, a silicon micro-analytical platform consisting of a three-dimensional micro-preconcentrator based on a hydrophobic zeolite, coupled to a silicon spiral micro-column was built. A chemical gas sensor acted as a miniaturized gas detector. This system allowed selective detection of orthonitrotoluene (ONT), an explosive-related compound at the sub-ppm level in the presence of toluene and moisture.

Stable expression in HEK-293 cells of the rat alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor.

1996

The alpha3/beta4 subtype of neuronal nicotinic acetylcholine receptor (nAChR) was stably expressed in human embryonic kidney (HEK) 293 cells that co-expressed a voltage-gated Ca2+ channel. alpha3/beta4-nAChR-expressing clones were identified using the fura-2 Ca2+ imaging technique, and were further characterised by single-cell and whole-cell patch-clamp studies. Acetylcholine (ACh) induced fast activating currents which showed desensitisation and inward rectification. The conductance of the ACh-activated channel was 29 pS. The order of potency of the nicotinic agonists tested was cytisine approximately = nicotine > acetylcholine. The EC50 value for ACh was 145 microM; the Hill coefficient w…

Effects of two-carbon bridge region methoxylation of benztropine: discovery of novel chiral ligands for the dopamine transporter

2001

6-Methoxylated and 8-oxygenated benztropines were prepared and evaluated for their DAT and SERT activity (binding and uptake inhibition). Methoxylation at the two-carbon bridge of benztropine produced a novel class of potent and selective DAT ligands. An interesting enantioselectivity was also observed for this new class of chiral benztropines. The inactivity of the 8-oxygenated analogues seems to point out that, unlike cocaine and its analogues, interactions of benztropine ligands with DAT may be strongly governed by the nitrogen atom.

A second pathway of activation of the Torpedo acetylcholine receptor channel

1991

We have studied the interaction of the reversible acetylcholine esterase inhibitor (-)physostigmine (D-eserine) with the nicotinic acetylcholine receptor (nAChR) from Torpedo marmorata electric tissue by means of ligand-induced ion flux into nAChR-rich membrane vesicles and of equilibrium binding. We find that (-) physostigmine induces cation flux (and also binds to the receptor) even in the presence of saturating concentrations of antagonists of acetylcholine, such as D-tubocurarine, alpha-bungarotoxin or antibody WF6. The direct action on the acetylcholine receptor is not affected by removal of the methylcarbamate function from the drug and thus is not due to carbamylation of the receptor…

A muscarinic mechanism inhibiting the release of noradrenaline from peripheral adrenergic nerve fibres by nicotinic agents.

1968

Electron Crystallography in Mineralogy and Materials Science

2006

The mineral aerinite is investigated by electron crystallography (NED and HREM). TEM results of aerinite are compared with X-ray and synchrotron powder diffraction data. Six selected area electron diffraction (SAED) patterns and two HREM images from Pb5MoO8 single crystals are used to solve their structure. The unit cell parameters of these crystals confirm the known powder diffraction data.

TCR V alpha chain expression influences reactivity to the hapten TNP.

1997

We have recently demonstrated a remarkable selection of in vitro cultivated, TNP-specific polyclonal T cell lines for the expression of a TCR beta chain encoded by the V beta 8.2 gene. The goal of the present study was to analyse V alpha usage in V beta 8.2 T cells responsive to TNP, using TNP-specific T cell lines derived from three common strains of mice, as well as from V beta 8.2 transgenic mice. Results indicate that in vitro TNP stimulation of T cells from TNP-immune mice results in significant skewing of V alpha usage among responding V beta 8.2+ T cells, with overexpression observed for V alpha 3.2 and V alpha 8. These results indicate that V alpha expression influences recognition …

Shared determinants between virus-infected and trinitrophenyl-conjugated H-2-identical target cells detected in cell-mediated lympholysis

1976

Infection of H-2-identical mice with either lymphocytic choriomeningitis (LCM) virus, vaccinia virus, or paramyxo (Sendai) virus resulted in the generation of specifically sensitized cytotoxic T lymphocytes (CTL). CTL generated in vitro against 2,4,6-trinitrophenyl (TNP)-conjugated syngeneic stimulator cells were specifically cytotoxic for TNP-conjugated H-2K (D) region identical targets. Both LCM and vaccinia-induced CTL, however, were found to be strongly cytotoxic towards TNP-conjugated, H-2K(D) region-identical target cells. In contrast, Sendai virus-induced CTL did not lyse TNP-conjugated, syngeneic target cells. Inhibition experiments using cold targets suggested that shared antigenic…

Il sacrificio di Abramo e il miracolo della fonte nell'arcosolio VII.21 della catacomba di Villagrazia di Carini

2014

I due temi di ispirazione biblica decorano un arcosolio per bambino nella parete orientale della galleria VII. Nella lunetta la scena del sacrificio, alla quale assiste una figura femminile di orante in tunica clavata e con l'acconciatura a turbante tipica del IV secolo. Nel sottarco si conserva solo la figura di Mosè che percuote con la verga la roccia da cui scaturisce l'acqua. I confronti rimandano soprattutto alla decorazione pittorica delle catacombe cristiane di Roma. Le implicazioni dottrinali sottese al tema della salvezza denotano una committenza aggiornata che predilige soggetti meno banali di quelli riscontrabili nei coevi contesti funerari urbani della Sicilia.

De S. Trinitate libri tres contra huius aeui Trinitarios, Antitrinitarios, [et] Autotheanos / G. Genebrardo ... auctore ...

1569

Sig. a8, A-V8, X4 Capitals grav. - Fris Text amb postil·les marginals. - Reclams al final de cada quadern