Search results for "Risk analysis"
showing 10 items of 375 documents
Exploiting Data Analytics and Deep Learning Systems to Support Pavement Maintenance Decisions
2021
Road networks are critical infrastructures within any region and it is imperative to maintain their conditions for safe and effective movement of goods and services. Road Management, therefore, plays a key role to ensure consistent efficient operation. However, significant resources are required to perform necessary maintenance activities to achieve and maintain high levels of service. Pavement maintenance can typically be very expensive and decisions are needed concerning planning and prioritizing interventions. Data are key towards enabling adequate maintenance planning but in many instances, there is limited available information especially in small or under-resourced urban road authorit…
Energy Management and Smart Grids
2013
The paper outlines energy management concepts and the smart grid evolution. The necessity of considering energy management as a crucial innovation in load supplying to permit a more powerful penetration of renewable energy usage at the building and city level and to perform energy savings and CO2 emissions reduction is pointed out. The driving factors to enhance the current power distribution are presented, and the benefits concerning smart grids are underlined. In the paper, a specific energy management analysis is reported by considering all the electric value chain, and the demand-side management and distributed on site control actions are described. To verify the benefit of energy manag…
Monitoring and prediction in early warning systems for rapid mass movements
2015
Rapid mass movements (RMM) pose a substantial risk to people and infrastructure. Reliable and cost-efficient measures have to be taken to reduce this risk. One of these measures includes establishing and advancing the state of practice in the application of early warning systems (EWSs). EWSs have been developed during the past decades and are rapidly increasing. In this paper, we focus on the technical part of EWSs, i.e., the prediction and timely recognition of imminent hazards, as well as on monitoring slopes at risk and released mass movements. Recent innovations in assessing spatial precipitation, monitoring and precursors of the triggering and deformation of RMM offer new opportunities…
Estimation of synthetic flood design hydrographs using a distributed rainfall–runoff model coupled with a copula-based single storm rainfall generator
2014
Abstract. In this paper a procedure to derive synthetic flood design hydrographs (SFDH) using a bivariate representation of rainfall forcing (rainfall duration and intensity) via copulas, which describes and models the correlation between two variables independently of the marginal laws involved, coupled with a distributed rainfall–runoff model, is presented. Rainfall–runoff modelling (R–R modelling) for estimating the hydrological response at the outlet of a catchment was performed by using a conceptual fully distributed procedure based on the Soil Conservation Service – Curve Number method as an excess rainfall model and on a distributed unit hydrograph with climatic dependencies for the …
Decision-Making Tools to Manage the Microbiology of Drinking Water Distribution Systems
2020
[EN] This paper uses a two-fold multi-criteria decision-making (MCDM) approach applied for the first time to the field of microbial management of drinking water distribution systems (DWDS). Specifically, the decision-making trial and evaluation laboratory (DEMATEL) was applied removing the need for reliance on expert judgement, and analysed interdependencies among water quality parameters and microbiological characteristics of DWDS composed of different pipe materials. In addition, the fuzzy technique for order preference by similarity to ideal solution (FTOPSIS) ranked the most common bacteria identified during trials in a DWDS according to their relative abundance while managing vagueness…
Lipid Delivery Systems for Nucleic-Acid-Based-Drugs: From Production to Clinical Applications
2019
In the last years the rapid development of Nucleic Acid Based Drugs (NABDs) to be used in gene therapy has had a great impact in the medical field, holding enormous promise, becoming “the latest generation medicine” with the first ever siRNA-lipid based formulation approved by the United States Food and Drug Administration (FDA) for human use, and currently on the market under the trade name Onpattro™. The growth of such powerful biologic therapeutics has gone hand in hand with the progress in delivery systems technology, which is absolutely required to improve their safety and effectiveness. Lipid carrier systems, particularly liposomes, have been proven to be the most su…
Developing and testing a discrete event simulation model to evaluate budget impacts of diabetes prevention programs
2020
Type 2 diabetes (T2D) is one of the most rapidly increasing non-communicable diseases worldwide. Lifestyle interventions are effective in preventing T2D but also resource intensive. This study evaluated with discrete event simulation (DES) the relative budget impacts of three hypothetical diabetes prevention programs (DPP), including group-based contact intervention, digital program with human coaching and fully automated program. The data for simulation were derived from research literature and national health and population statistics. The model was constructed using the iGrafx Process for Six Sigma software and simulations were carried out for 10 years. All simulated interventions produc…
Application of the threshold of toxicological concern (TTC) to the safety evaluation of cosmetic ingredients.
2007
The threshold of toxicological concern (TTC) has been used for the safety assessment of packaging migrants and flavouring agents that occur in food. The approach compares the estimated oral intake with a TTC value derived from chronic oral toxicity data for structurally-related compounds. Application of the TTC approach to cosmetic ingredients and impurities requires consideration of whether route-dependent differences in first-pass metabolism could affect the applicability of TTC values derived from oral data to the topical route. The physicochemical characteristics of the chemical and the pattern of cosmetic use would affect the long-term average internal dose that is compared with the re…
Developmental programming of energy balance and its hypothalamic regulation.
2011
Developmental programming is an important physiological process that allows different phenotypes to originate from a single genotype. Through plasticity in early life, the developing organism can adopt a phenotype (within the limits of its genetic background) that is best suited to its expected environment. In humans, together with the relative irreversibility of the phenomenon, the low predictive value of the fetal environment for later conditions in affluent countries makes it a potential contributor to the obesity epidemic of recent decades. Here, we review the current evidence for developmental programming of energy balance. For a proper understanding of the subject, knowledge about ene…
[Insight on how to assess and improve the response to the COVID-19 pandemic].
2022
Resumen: La pandemia de COVID-19 ha afectado de manera particularmente intensa a España, pese a su nivel de desarrollo y la elogiada solidez de su Sistema Nacional de Salud. Para comprender qué ha pasado e identificar cómo mejorar la respuesta creemos imprescindible una evaluación independiente multidisciplinaria de la esfera sanitaria, política y socioeconómica. En este trabajo proponemos objetivos, principios, metodología y dimensiones a evaluar, además de esbozar el tipo de resultados y conclusiones esperadas. Nos inspiramos en los requerimientos formulados por el panel independiente de la Organización Mundial de la Salud y en las experiencias evaluativas en otros países, y detallamos la…