Search results for "Rite"
showing 10 items of 2726 documents
A New Hybrid Mutation Operator for Multiobjective Optimization with Differential Evolution
2011
Differential evolution has become one of the most widely used evolution- ary algorithms in multiobjective optimization. Its linear mutation operator is a sim- ple and powerful mechanism to generate trial vectors. However, the performance of the mutation operator can be improved by including a nonlinear part. In this pa- per, we propose a new hybrid mutation operator consisting of a polynomial based operator with nonlinear curve tracking capabilities and the differential evolution’s original mutation operator, to be efficiently able to handle various interdependencies between decision variables. The resulting hybrid operator is straightforward to implement and can be used within most evoluti…
Flexible Data Driven Inventory Management with Interactive Multiobjective Lot Size Optimization
2021
We study data-driven decision support and formalise a path from data to decision making. We focus on lot sizing in inventory management with stochastic demand and propose an interactive multi-objective optimisation approach. We forecast demand with a Bayesian model, which is based on sales data. After identifying relevant objectives relying on the demand model, we formulate an optimisation problem to determine lot sizes for multiple future time periods. Our approach combines different interactive multi-objective optimisation methods for finding the best balance among the objectives. For that, a decision maker with substance knowledge directs the solution process with one’s preference inform…
Multiobjective shape design in a ventilation system with a preference-driven surrogate-assisted evolutionary algorithm
2019
We formulate and solve a real-world shape design optimization problem of an air intake ventilation system in a tractor cabin by using a preference-based surrogate-assisted evolutionary multiobjective optimization algorithm. We are motivated by practical applicability and focus on two main challenges faced by practitioners in industry: 1) meaningful formulation of the optimization problem reflecting the needs of a decision maker and 2) finding a desirable solution based on a decision maker’s preferences when solving a problem with computationally expensive function evaluations. For the first challenge, we describe the procedure of modelling a component in the air intake ventilation system wi…
Projections onto the Pareto surface in multicriteria radiation therapy optimization
2015
Purpose: To eliminate or reduce the error to Pareto optimality that arises in Pareto surface navigation when the Pareto surface is approximated by a small number of plans. Methods: The authors propose to project the navigated plan onto the Pareto surface as a postprocessing step to the navigation. The projection attempts to find a Pareto optimal plan that is at least as good as or better than the initial navigated plan with respect to all objective functions. An augmented form of projection is also suggested where dose–volume histogram constraints are used to prevent that the projection causes a violation of some clinical goal. The projections were evaluated with respect to planning for int…
Los caballos en la Cova del Parpalló (Gandía, Valencia)
2005
Se estudian 165 plaquetas grabadas de la Cova del Parpalló, de las que 115 contienen una o varias representaciones de caballos que siguen las mismas grandes tendencias sugeridas por Villaverde. Es posible, con todo, señalar la existencia de dos subtendencias: por un lado un creciente grosor de los trazos, y por otro la consecución del volumen a través de trazos múltiples y repetidos. La tendencia a desarrollar el volumen está en correlación con el alargamiento del cuello y la representación dinámica del pecho, mediante una línea oblicua proyectada hacia adelante. Nuestra intención es, además, poner de manifiesto las concomitancias que se registran en el Solutro-gravetiense entre los cambios…
Modelling the spatial and temporal constrains of the GABAergic influence on neuronal excitability
2021
GABA (γ-amino butyric acid) is an inhibitory neurotransmitter in the adult brain that can mediate depolarizing responses during development or after neuropathological insults. Under which conditions GABAergic membrane depolarizations are sufficient to impose excitatory effects is hard to predict, as shunting inhibition and GABAergic effects on spatiotemporal filtering of excitatory inputs must be considered. To evaluate at which reversal potential a net excitatory effect was imposed by GABA (EGABAThr), we performed a detailed in-silico study using simple neuronal topologies and distinct spatiotemporal relations between GABAergic and glutamatergic inputs. These simulations revealed for GABAe…
Sequential acquisition of cacophony calcium currents, sodium channels and voltage-dependent potassium currents affects spike shape and dendrite growt…
2014
During metamorphosis the CNS undergoes profound changes to accommodate the switch from larval to adult behaviors. In Drosophila and other holometabolous insects, adult neurons differentiate either from respecified larval neurons, newly born neurons, or are born embryonically but remain developmentally arrested until differentiation during pupal life. This study addresses the latter in the identified Drosophila flight motoneuron 5. In situ patch-clamp recordings, intracellular dye fills and immunocytochemistry address the interplay between dendritic shape, excitability and ionic current development. During pupal life, changes in excitability and spike shape correspond to a stereotyped, progr…
Immunohistochemical detection of early myocardial infarction: a systematic review
2017
The postmortem diagnosis of early myocardial infarction is a challenge for forensic pathologists because the routine histology is neither specific. Many authors have suggested the use of the immunohistochemistry to fill the gaps in the histological diagnosis of early myocardial infarction. This review aims to analyse advances of immunohistochemical detection of early cardiac damage due to ischaemia. To this purpose, we reviewed experimental studies that investigated immunohistochemical markers and their estimated timing of expression. The review was performed according to specific inclusion and exclusion criteria, and a total of 23 studies assessing the immunohistochemical markers for the d…
Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives
2015
Advanced knowledge in the field of stem cell biology and their ability to provide a cue for counteracting several diseases are leading numerous researchers to focus their attention on “regenerative medicine” as possible solutions for cardiovascular diseases (CVDs). However, the lack of consistent evidence in this arena has hampered the clinical application. The same condition affects the research on endothelial progenitor cells (EPCs), creating more confusion than comprehension. In this review, this aspect is discussed with particular emphasis. In particular, we describe biology and physiology of EPCs, outline their clinical relevance as both new predictive, diagnostic, and prognostic CVD b…
Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus
2012
Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer's disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus of young (4- to 6-month-old) PS1(M146L)/APP(751SL) mice model, as the initial degenerative process underlying functional disturbance prior to neuronal loss. Neuritic plaques accounted for almost all fibrillar deposits and an axonal origin of the dystrophies was demonstrated. The early induction of autophagy pathology was evidenced by increased protein levels of the autophagosome marker LC3 that was localized in the axonal dystrophies, and by electron microscopic identification…