Search results for "Rite"
showing 10 items of 2726 documents
A framework for remission in SLE
2017
ObjectivesTreat-to-target recommendations have identified ‘remission’ as a target in systemic lupus erythematosus (SLE), but recognise that there is no universally accepted definition for this. Therefore, we initiated a process to achieve consensus on potential definitions for remission in SLE.MethodsAn international task force of 60 specialists and patient representatives participated in preparatory exercises, a face-to-face meeting and follow-up electronic voting. The level for agreement was set at 90%.ResultsThe task force agreed on eight key statements regarding remission in SLE and three principles to guide the further development of remission definitions:1. Definitions of remission wi…
Injury Evaluation in Teenage Cyclist-Vehicle Crash by Multibody Simulation
2014
Information on impact locations, impact situations and cyclist and pedestrian dynamics in impacts with passenger cars is fundamental for the development of effective solutions to improve cyclist and pedestrian protection. Accidentology research shows that cyclists typically have a higher impact location than the pedestrian, with a larger share of injuries from the windscreen area. Majority of accidents in Palermo, in the last years, happens at urban street (84%) that involve teenager (6.4%). In this paper simulation study captures dynamics and injuries to head and chest for teenager between a generic bicycle and a car model that is suitable for pedestrian or cyclist safety. Multibody simula…
EULAR/PRINTO/PRES criteria for Henoch-Schonlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arte…
2010
EULAR/PRINTO/PRES Objectives To validate the previously proposed classification criteria for Henoch-Schonlein purpura (HSP), childhood polyarteritis nodosa (c-PAN), c-Wegener granulomatosis (c-WG) and c-Takayasu arteritis (c-TA).Methods Step 1: retrospective/prospective webdata collection for children with HSP, c-PAN, c-WG and c-TA with age at diagnosis <= 18 years. Step 2: blinded classification by consensus panel of a representative sample of 280 cases. Step 3: statistical (sensitivity, specificity, area under the curve and.-agreement) and nominal group technique consensus evaluations.Results 827 patients with HSP, 150 with c-PAN, 60 with c-WG, 87 with c-TA and 52 with c-other were compar…
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics stud…
2008
Contains fulltext : 71374.pdf (Publisher’s version ) (Closed access) Attention-deficit/hyperactivity disorder (ADHD) is typically characterized by inattention, excessive motor activity, impulsivity, and distractibility. Individuals with ADHD have significant impairment in family and peer relations, academic functioning, and show high co-morbidity with a wide range of psychiatric disorders including oppositional defiant disorder (ODD), conduct disorder (CD), anxiety disorder, depression, substance abuse, and pervasive developmental disorder (PDD). Family studies suggest that ADHD + CD represents a specific subtype of the ADHD disorder with familial risk factors only partly overlapping with t…
Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder
2008
Contains fulltext : 69243.pdf (Publisher’s version ) (Closed access) Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P(S…
No association between two polymorphisms of the serotonin transporter gene and combined type attention deficit hyperactivity disorder.
2008
Contains fulltext : 71091.pdf (Publisher’s version ) (Closed access) Several independent studies have reported association between serotonin transporter gene (SLC6A4) polymorphisms and attention deficit hyperactivity disorder (ADHD). Five studies found evidence for association between the long-allele of a 44-bp insertion/deletion polymorphism (5-HTTLPR) and ADHD. Another two studies corroborated this finding while a further six studies did not find such an association. For a second polymorphism within the gene, a variable number tandem repeat (VNTR) within intron 2, one study demonstrated that the 12/12 genotype was significantly less frequent in ADHD cases compared to controls, while a sec…
Sponges (Porifera) model systems to study the shift from immortal to senescent somatic cells: the telomerase activity in somatic cells.
1998
Abstract Sponges (Porifera) represent the lowest metazoan phylum, characterized by a pronounced plasticity in the determination of cell lineages. In a first approach to elucidate the molecular mechanisms controlling the switch from the cell lineage with a putative indefinite growth capacity to senescent, somatic cells, the activity of the telomerase as an indicator for immortality has been determined. The studies were performed with the marine demosponges Suberites domuncula and Geodia cydonium . It was found that the activity for the telomerase in the tissue of both sponges is high; a quantitative analysis revealed that the extract from S. domuncula contained 10.3 TPG units per 5000 cell e…
Bauplan of Urmetazoa: Basis for Genetic Complexity of Metazoa
2004
Sponges were first grouped to the animal-plants or plant-animals then to the Zoophyta or Mesozoa and finally to the Parazoa. Only after the application of molecular biological techniques was it possible to place the Porifera monophyletically with the other metazoan phyla, justifying a unification of all multicellular animals to only one kingdom, the Metazoa. The first strong support came from the discovery that cell-cell and cell-matrix adhesion molecules that were cloned from sponges and were subsequently expressed share a high DNA sequence and protein function similarity with the corresponding molecules of other metazoans. Besides these evolutionary novelties for Metazoa, sponges also hav…
Gully erosion susceptibility mapping using GIS-based multi-criteria decision analysis techniques
2019
Abstract This research introduces a scientific methodology for gully erosion susceptibility mapping (GESM) that employs geography information system (GIS)-based multi-criteria decision analysis. The model was tested in Semnan Province, Iran, which has an arid and semi-arid climate with high susceptibility to gully erosion. The technique for order of preference by similarity to ideal solution (TOPSIS) and the analytic hierarchy process (AHP) multi-criteria decision-making (MCDM) models were integrated. The important aspect of this research is that it did not require gully erosion inventory maps for GESM. Therefore, the proposed methodology could be useful in areas with missing or incomplete …
PIANCALDOLI METEORITE: CHEMISTRY, MINERALOGY AND PETROLOGY
1976
The fall occurred near Piancaldoli, Florence, Italy, at 19.14 U.T. on the 10th August 1968. The fireball broke up in the atmosphere producing a cloud like a balloon. The trajectory and the terminal point were calculated, leading to the recovery of three small meteoritic fragments, found on the roof of a house. Chemical analysis gave the following results: SiO2 40.80; TiO2 0.15; Al2O3 2. 70; Cr2O3 0.47; FeO 17.20; MnO 0.07; MgO 25.18; CaO 1.95; Na2O 0.64; K2O 0.07; P2O5 0.20; NiS 0.93; FeS 6.24; Fe° 2.40; Ni° 0.40; Co 0.05; sum 99.45. In the lithic portion of the meteorite the following minerals were found: both clino and orthopyroxenes (En = 76 to 98%), olivines (Fo = 66 to 98%), troilite, …