Search results for "Role"

The geological CO2degassing history of a long-lived caldera

2015

The majority of the ~100 Holocene calderas on Earth host vigorously active hydrothermal systems, the heat and volatile budgets of which are sustained by degassing of deeply stored magma. Calderas may thus contribute a nontrivial, although poorly quantified, fraction of the global budget of magmatic volatiles such as CO2. Here we use original isotopic a d petrological results from Campi Flegrei volcano, Italy, to propose that hydrothermal calcites are natural mineral archives for the magmatic CO2 that reacted with reservoir rocks during the geological history of a caldera. We show that Campi Flegrei calcites, identified in core samples extracted from 3-km-deep geothermal wells, formed at iso…

Analysis of Antiproliferative and Chemosensitizing Effects of Sunitinib on Human Esophagogastric Cancer Cells: Synergistic Interaction With Vandetani…

2009

The receptor tyrosine kinases (RTKs), epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor 1-3 (VEGFR1-3), are frequently expressed in gastric cancer and are putative therapeutic targets in this disease. We have investigated the anti-proliferative and chemosensitizing properties of the multitargeted small-molecule RTK inhibitors sunitinib and vandetanib in a panel of 4 human gastric and esophageal cancer cell lines. In the 1st instance, the expression of potential targets of these small-molecule inhibitors was examined by reverse transcriptase-polymerase chain reaction, western blotting, and flow cytometry. EGFR mRNA and protein was detected in all cases, …

Experimental assessment of the hydro-mechanical behaviour of a shale caprock during CO2 injection

2021

Abstract The presented experimental study focuses on the hydro-mechanical characterisation of a shale caprock (Opalinus Clay) in contact with carbon dioxide. The objective of this paper, consists in the evaluation of the material's sealing capacity in terms of entry-pressure, mechanical behaviour and sensitivity of the transport properties to chemo-mechanical effects induced by gaseous and liquid CO2 injection. Two types of Opalinus Clay core samples are tested; shaly and carbonate-rich. The sealing capacity has been evaluated on the shaly OPA according to the stepwise and the residual methods and compared to the results from mercury intrusion porosimetry. The obtained results and the diffe…

Substituent effect of nitro group on aromaticity of carbazole rings

2014

The molecular geometries of carbazole and its 17 nitro derivatives were optimized at the B3LYP/6-311++G(2d,2p) level of theory. The harmonic oscillator model of aromaticity and nucleus-independent chemical shift descriptors of π-electron delocalization were calculated to estimate the aromaticity of the carbazole five- and six-membered rings. The biggest changes in the value of both descriptors were observed for the pyrrole ring. The nitro group attached to 3 and/or 6 positions of the carbazole ring system exerts only a slight influence on the benzene ring aromaticity.

Carbonate Platform-Basin Transition in SW Sicily. Implications for the Petroleum Exploration in the Maghrebian Thrust and Fold Belt

2009

Highly Fluorescent and Water-Soluble Diketopyrrolopyrrole Dyes for Bioconjugation

2015

International audience; The preparation of highly water-soluble and strongly fluorescent diketopyrrolopyrrole (DPP) dyes using an unusual taurine-like sulfonated linker has been achieved. Exchanging a phenyl for a thienyl substituent shifts the emission wavelength to near λ=600 nm. The free carboxylic acid group present in these new derivatives was readily activated and the dyes were subsequently covalently linked to a model protein (bovine serum albumin; BSA). The bioconjugates were characterized by electronic absorption, fluorescence spectroscopy and MALDI-TOF mass spectrometry, thus enabling precise determination of the labeling density (ratio DPP/BSA about 3 to 8). Outstanding values of…

The influence of atorvastatin on parameters of inflammation left ventricular function, hospitalizations and mortality in patients with dilated cardio…

2013

Background: We assessed the influence of atorvastatin on selected indicators of an inflammatory condition, left ventricular function, hospitalizations and mortality in patients with dilated cardiomyopathy (DCM). Methods. We included 68 DCM patients with left ventricular ejection fraction (LVEF) ≤40% treated optimally in a prospective, randomized study. They were observed for 5 years. Patients were divided into two groups: patients who were commenced on atorvastatin 40 mg daily for two months followed by an individually matched dose of 10 or 20 mg/day (group A), and patients who were treated according to current recommendations without statin therapy (group B). Results: After 5-year follow-u…

Ģimenes anamnēzes raksturojums pacientiem ar primāru hiperlipidēmiju

2018

Tēmas aktualitāte: Ģimenes hiperholesterinēmija (ĢH) ir autosomāli ominant slimība, kas savlaicīgi neatpazīstot un neuzsākot atbilstošu terapiju, var rezultēties agrīnos kardiovaskulāros notikumos. Latvija ir pirmā no Baltijas valstīm, kur funkcionē ĢH reģistrs. Mērķis: Raksturot ģimenes anamnēzes datu pieejamību pacientiem, kas iekļauti LĢRH. Materiāli un metodes: Tika analizēta ģimenes slimības vēstures datu pieejamība, izmantojot LĢHR pacientu anketas. Rezultāti: Līdz 2017. gada oktobrim LĢHR tika iekļauti 356 pacienti, no kuriem 294 (82.6%) bija probandi un 62 ( 17.4%) pirmās pakāpes radinieki. Klīniska ĢH tika diagnosticēta 164 pacientiem (131 probandam un 33 pirmās pakāpes radiniekiem…

Timely recognition of cardiovascular toxicity by anticancer agents: a common objective of the pharmacologist, oncologist and cardiologist.

2011

Both conventional and new anticancer drugs can frequently cause adverse cardiovascular effects, which can span from subclinical abnormalities to serious life-threatening and sometimes fatal events. This review examines the principal basic and clinical elements that may be of profit to identify, prevent and treat such toxicities. Clearly, the accomplishment of such objectives requires the strong commitment and cooperation of different professional figures including, but not limited to, pharmacologists, oncologists and cardiologists. The aspect of anticancer drug cardiotoxicity seems to be somehow underestimated, mainly due to inadequate reporting of adverse reactions from oncology drugs in t…

Polyvascular subclinical atherosclerosis in familial hypercholesterolemia: The role of cholesterol burden and gender

2019

International audience; BACKGROUND AND AIM:Heterozygous familial hypercholesterolemia (HeFH) is a genetic disease characterized by a heterogeneous phenotype. The assessment of cardiovascular (CV) risk is challenging for HeFH. Cholesterol burden (CB) allows to estimate the lifelong exposure to high levels of cholesterol. The aim of this study was to analyze the distribution of subclinical atherosclerosis and the relationship between atherosclerosis and the CB in a sample of HeFH patients, focusing on sex-related differences.METHODS AND RESULTS:154 asymptomatic HeFH subjects underwent coronary-artery-calcium score (CACs) and Doppler ultrasound of carotid and femoral arteries. Yearly lipid pro…