Search results for "Romu"
showing 10 items of 445 documents
High pancuronium sensitivity of axonal nicotinic-acetylcholine receptors in humans during organophosphate intoxication.
1991
The effect of low-dose pancuronium on neuromuscular transmission was studied in 2 patients during the early and late stages of severe organophosphate intoxication. Single evoked compound muscle action potentials (CMAP) were followed by repetitive discharges and a decrement-increment (D-I) phenomenon with 10-, 20-, and 50-Hz supramaximal nerve stimulation. Intravenous pancuronium, 1 mg, abolished the D-I phenomenon, while the repetitive discharges of the CMAP were only partially reduced. It is postulated, that the disappearance of the D-I phenomenon with persistence of the CMAP repetitive discharges results from blockade of nicotinic-acetylcholine receptors located on the terminal axon respo…
Kullan talteenotto sähkö- ja elektroniikkaromusta
2017
Tutkielman kirjallisessa osassa käydään läpi yleisesti kiertotaloutta ja metallien osuutta kiertotaloudessa. Lisäksi kirjallisessa osassa keskitytään sähkö- ja elektroniikkaromun kasvavaan määrään ja sen kierrätyksen tärkeyteen sekä kierrätyksen ongelmiin. Työssä käydään läpi yleiset kullan talteenottotavat, hydrometallurgia, pyrometallurgia sekä fysikaalinen ja mekaaninen erottelu, joita on tutkittu sähkö ja elektroniikkaromun kierrätykseen. Myös yleisimmät kullan analysoinnissa käytetyt menetelmät käydään läpi kirjallisen osan loppuvaiheessa. Kullan talteenotolle kehitettiin menetelmä, jonka avulla kulta pystyttiin ottamaan talteen jopa yli 99 % puhtaudella ja 60–70 % saannoilla liuotetus…
Practical application of electron microscopy to neuromuscular diseases.
2013
Concerning individual neuromuscular conditions, electron microscopy may be considered “essential,” “helpful,” or “wasteful.” “Essential” electron microscopy should provide a clear diagnosis, because of the disease specificity of the ultrastructural findings, in particular as to inclusions within muscle fibers, such as cylindrical spirals and reducing bodies. Electron microscopy may be “helpful” in detecting ultrastructural features preceding typical light microscopic findings, for instance, undulating tubules in endothelial cells. Congenital, metabolic, and inflammatory myopathies may often be more easily and more reliably diagnosed by means of the electron microscope. Diagnostically “waste…
The transcription factor Zfh1 is involved in the regulation of neuropeptide expression and growth of larval neuromuscular junctions in Drosophila mel…
2008
AbstractDifferent aspects of neural development are tightly regulated and the underlying mechanisms have to be transcriptionally well controlled. Here we present evidence that the transcription factor Zfh1, the Drosophila member of the conserved zfh1 gene family, is important for different steps of neuronal differentiation. First, we show that late larval expression of the neuropeptide FMRFamide is dependent on correct levels of Zfh1 and that this regulation is presumably direct via a conserved zfh1 homeodomain binding site in the FMRFamide enhancer. Using MARCM analysis we additionally examined the requirement for Zfh1 during embryonic and larval stages of motoneuron development. We could …
Pain Phenotypes in Rare Musculoskeletal and Neuromuscular Diseases
2020
For patients diagnosed with a rare musculoskeletal or neuromuscular disease, pain may transition from acute to chronic; the latter yielding additional challenges for both patients and care providers. We assessed the present understanding of pain across a set of ten rare, noninfectious, noncancerous disorders; Osteogenesis Imperfecta, Ehlers-Danlos Syndrome, Achondroplasia, Fibrodysplasia Ossificans Progressiva, Fibrous Dysplasia/McCune-Albright Syndrome, Complex Regional Pain Syndrome, Duchenne Muscular Dystrophy, Infantile- and Late-Onset Pompe disease, Charcot-Marie-Tooth Disease, and Amyotrophic Lateral Sclerosis. Through the integration of natural history, cross-sectional, retrospective…
Effects of Neuromuscular Blocking Agents on Neuronal Nicotine Receptors of Motor Nerves: Blockade of Nicotinic Autofacilitation and Backfiring
1991
ABSTRACT Tubocurarine reduced (60%) [3H]acetylcholine release from the isolated rat phrenic nerve at concentrations of 1 or 10 μM, but blocked backfiring of the phrenic nerve occuring after partial blockade of cholinesterase already at a concentration of 100 nM. The distinct potency of tubocurarine suggests differences between the presynaptic nicotine receptors mediating autofacilitation of release and preterminal nicotine receptors mediating backfiring of the motor nerve or a low agonist concentration at the latter receptors. The new neuromuscular blocking agents atracurium, pancuronium and vecuronium less effectively reduced [3H]acetylcholine release than tubocurarine indicating a lower a…
L’immagine dei Normanni di Sicilia nella letteratura latina del XII secolo
2016
La dominazione normanna della Sicilia e dell'Italia meridionale, fra XI e XII secolo, è stata letta e interpretata in vario modo dagli scrittori contemporanei, sia quelli di parte bizantina, sia quelli occidentali. In questo saggio, dopo una breve premessa concernente i principali fatti storici e le relative fonti bizantine, ci si concentra sulla disamina di alcuni fra i principali scrittori e poeti che, tra la fine dell'XI e tutto il XII secolo, si sono occupati della dominazione normanna di Sicilia, cercando di individuare e di illustrare, caso per caso, la visione che essi ebbero dei Normanni conquistatori. Si discorre qui, nell'ordine, di Amato da Montecassino, Goffredo Malaterra, Gugli…
Efficacy of obidoxime in human organophosphorus poisoning: determination by neuromuscular transmission studies.
1995
Six patients with organophosphorus compound intoxications developed an intermediate syndrome (weakness and fasciculations) and obidoxime was given on eight occasions. The efficacy of the acetylcholinesterase (AChE) reactivator was monitored electrophysiologically by neuromuscular transmission studies using single and repetitive nerve stimulation (20 and 50 Hz) and the activity of the serum (butyryl) cholinesterase (ChE). Dramatic electrophysiologic improvement was seen when obidoxime was given early within 12 h in 3 patients, although evidence of AChE inhibition did not subside completely. When administration of obidoxime was delayed 26 h or more after intoxication on five occasions, electr…
Rituximab in AChR subtype of myasthenia gravis: systematic review
2020
Myasthenia gravis (MG) is a chronic autoimmune disorder of the neuromuscular junction characterised by an autoantibody against acetylcholine receptor (AChR-Ab), autoantibody against muscle-specific kinase (MuSK-Ab), lipoprotein-related protein 4 or agrin in the postsynaptic membrane at the neuromuscular junction. Many patients are resistant to conventional treatment and effective therapies are needed. Rituximab (RTX) is a monoclonal antibody directed against CD20 antigen on B cells which has been successfully employed in anti-MuSK-Ab+MG, but the efficacy in anti-AChR-Ab+MG is still debated. The purpose of this systematic review was to describe the best evidence for RTX in the acetylcholine …