6533b827fe1ef96bd1286e25

RESEARCH PRODUCT

Effects of Neuromuscular Blocking Agents on Neuronal Nicotine Receptors of Motor Nerves: Blockade of Nicotinic Autofacilitation and Backfiring

Thomas VogtK. WagenmannRoland BesserI. WesslerE. Jung

subject

NicotineAgonistNicotinic agonistChemistrymedicine.drug_classmedicineMotor nervePharmacologyNeuromuscular Blocking AgentsReceptorAcetylcholinemedicine.drugPhrenic nerve

description

ABSTRACT Tubocurarine reduced (60%) [3H]acetylcholine release from the isolated rat phrenic nerve at concentrations of 1 or 10 μM, but blocked backfiring of the phrenic nerve occuring after partial blockade of cholinesterase already at a concentration of 100 nM. The distinct potency of tubocurarine suggests differences between the presynaptic nicotine receptors mediating autofacilitation of release and preterminal nicotine receptors mediating backfiring of the motor nerve or a low agonist concentration at the latter receptors. The new neuromuscular blocking agents atracurium, pancuronium and vecuronium less effectively reduced [3H]acetylcholine release than tubocurarine indicating a lower affinity to the presynaptic nicotine receptors.

yearjournalcountryeditionlanguage
1991-01-01
https://doi.org/10.1016/b978-0-08-041165-1.50016-8