Search results for "S.r.l."
showing 10 items of 4041 documents
Self-organised symmetry breaking in zebrafish reveals feedback from morphogenesis to pattern formation
2019
A fundamental question in developmental biology is how the early embryo breaks initial symmetry to establish the spatial coordinate system later important for the organisation of the embryonic body plan. In zebrafish, this is thought to depend on the inheritance of maternal mRNAs [1–3], cortical rotation to generate a dorsal pole of beta-catenin activity [4–8] and the release of Nodal signals from the yolk syncytial layer (YSL) [9–12]. Recent work aggregating mouse embryonic stem cells has shown that symmetry breaking can occur in the absence of extra-embryonic tissue [19,20]. To test whether this is also true in zebrafish, we separated embryonic cells from the yolk and allowed them to deve…
Sural nerve biopsy studies in leigh's subacute necrotizing encephalomyelopathy
1986
Peripheral neuropathy marked by reduced nerve conduction velocities was found in four unrelated children, between the ages of 15 months and 9 years, whose autopsies revealed Leigh's subacute necrotizing encephalomyelopathy. Sural nerve biopsies disclosed primary demyelination and remyelination, as well as loss of myelinated and unmyelinated axons. The use of morphometric and electron microscopic studies shows that these techniques may reveal peripheral neuropathy in Leigh's disease more often than light microscopic methods alone.
Correction
2019
ABSTRACT During gastrulation, embryonic cells become specified into distinct germ layers. In mouse, this continues throughout somitogenesis from a population of bipotent stem cells called neuromesodermal progenitors (NMps). However, the degree of self-renewal associated with NMps in the fast-developing zebrafish embryo is unclear. Using a genetic clone-tracing method, we labelled early embryonic progenitors and found a strong clonal similarity between spinal cord and mesoderm tissues. We followed individual cell lineages using light-sheet imaging, revealing a common neuromesodermal lineage contribution to a subset of spinal cord tissue across the anterior-posterior body axis. An initial pop…
Neuromesodermal Progenitors are a Conserved Source of Spinal Cord with Divergent Growth Dynamics
2018
AbstractDuring gastrulation, embryonic cells become specified into distinct germ layers. In mouse, this continues throughout somitogenesis from a population of bipotent stem cells called neuromesodermal progenitors (NMps). However, the degree self-renewal is associated with NMps in the fast-developing zebrafish embryo is unclear. With a genetic clone tracing method, we labelled early embryonic progenitors and find a strong clonal similarity between spinal cord and mesoderm tissues. We then followed individual cell lineages by light-sheet imaging and reveal a common neuromesodermal lineage contribution to a subset of spinal cord tissue across the anterior-posterior body axis. An initial popu…
A cross-sectional study of pre-service teachers’ views about disability and attitudes towards inclusive education
2016
Teachers’ attitudes towards students with disabilities and special educational needs (SEN) and their inclusion in regular education classrooms have been internationally identified as a key factor in the implementation of inclusive education. In this study, 501 participants representing a cross-section of pre-service teachers from three public colleges of education in Ghana were surveyed about their views regarding disability, level of discomfort interacting with people with disabilities and attitudes towards inclusive education. The results indicate that the pre-service teachers understood disability as an interaction between biological and environmental factors and felt comfortable interac…
A Dynamic Software Startup Competency Model
2019
Current literature suggests that engineering activities of software engineering and software startup engineering differ. Thus, there is the need to elicit competencies specific for software startup engineering. This paper proposes a model that provides the various types of competencies and their respective relevance at the various stages of software startup evolution. peerReviewed
Coffins in Finland : the history of production, design and attitudes
2017
AbstractCoffins as death-related objects have changed in Finland during the past 150 years and the Finnish funeral industry has been created to answer the changing needs of customers. No longer do people build coffins in the household, or only buy a coffin and some other items from the funeral company: now professionals manage entire funerals. Coffin designs have become simpler and less socially discriminating and the colour formerly reserved for children and young people, white, has become the most popular colour for a coffin. Attitudes towards coffins have also changed, from mild dislike of having a coffin in the home to general demand of hiding coffins even in funeral companies’ premises…
Users’ Opinion About a Virtual Reality System as an Adjunct to Psychological Treatment for Stress-Related Disorders: A Quantitative and Qualitative M…
2018
This study aims to explore patients’ and therapists’ attitudes about the psychological treatment they received (patients) or applied (therapists). The treatments were standard CBT protocols for post-traumatic stress disorder (PTSD), complicated grief (CG), or adjustment disorders (ADs), depending on each patient diagnosis. The treatments were delivered following a traditional format or supported by a virtual reality (VR) system “EMMA’s WORLD” designed for the treatment of stress-related disorders. “EMMA’s WORLD” is a VR application in which patients can explore negative experiences using different virtual elements that can be customized to make them more meaningful to the user. The sample w…
Clients’ Experiences With Internet-Based Psychological Treatments for Mental Disorders: Protocol for a Metasynthesis of Qualitative Studies
2018
Background: Given the rise of internet-based treatments as an effective therapeutic tool for psychological disorders, it is necessary to carry out research that examines clients’ experiences with this type of intervention. The qualitative methodology has been found to be useful for analyzing clients’ perceptions in terms of facilitators and barriers, acceptability, and negative effects of internet-based treatments. However, a lack of integration of these primary studies has prevented their findings from being applied to new research and in clinical practice. Objective: The objective of this paper is to describe the protocol for a metasynthesis of qualitative studies exploring the experience…
Operational and financial performance of Italian airport companies: A dynamic graphical model
2016
Abstract This paper provides evidence on the relationship within a set of financial and operational indicators for Italian airports over 2008–2014. The limited sample size of national and regional airports suggests to apply the penalised RCON ( V , E ) model, which falls within the class of Gaussian graphical models. It provides both estimate and easy way to visualise conditional independence structures of the variables. Moreover, it is particularly suitable for handling longitudinal data where small number of units and huge number of variables have been collected. Findings highlight that a qualified concept of size matters in determining good financial performance. Specifically, increasing…