6533b7defe1ef96bd127660c
RESEARCH PRODUCT
Sural nerve biopsy studies in leigh's subacute necrotizing encephalomyelopathy
Hans H. GoebelA. BardosiM. AlbaniReinhard L. FriedeHartmut SiemesAlfried Kohlschüttersubject
0303 health sciencesPathologymedicine.medical_specialtymedicine.diagnostic_testPhysiologyPrimary demyelinationbusiness.industrySural nerveSural nerve biopsymedicine.disease03 medical and health sciencesCellular and Molecular Neuroscience0302 clinical medicinemedicine.anatomical_structurePeripheral neuropathyPhysiology (medical)BiopsymedicineNeurology (clinical)RemyelinationLeigh diseasebusinessElectron microscopic030217 neurology & neurosurgery030304 developmental biologydescription
Peripheral neuropathy marked by reduced nerve conduction velocities was found in four unrelated children, between the ages of 15 months and 9 years, whose autopsies revealed Leigh's subacute necrotizing encephalomyelopathy. Sural nerve biopsies disclosed primary demyelination and remyelination, as well as loss of myelinated and unmyelinated axons. The use of morphometric and electron microscopic studies shows that these techniques may reveal peripheral neuropathy in Leigh's disease more often than light microscopic methods alone.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1986-02-01 | Muscle & Nerve |