Search results for "S1"
showing 10 items of 755 documents
Are local food chains more sustainable than global food chains? Considerations for assessment
2016
© 2016 by the authors; licensee MDPI, Basel, Switzerland. This paper summarizes the main findings of the GLAMUR project which starts with an apparently simple question: is "local" more sustainable than "global"? Sustainability assessment is framed within a post-normal science perspective, advocating the integration of public deliberation and scientific research. The assessment spans 39 local, intermediate and global supply chain case studies across different commodities and countries. Assessment criteria cover environmental, economic, social, health and ethical sustainability dimensions. A closer view of the food system demonstrates a highly dynamic local-global continuum where actors, whil…
Mutations in DNA Binding and Transactivation Domains Affect the Dynamics of Parvovirus NS1 Protein
2013
ABSTRACT The multifunctional replication protein of autonomous parvoviruses, NS1, is vital for viral genome replication and for the control of viral protein production. Two DNA-interacting domains of NS1, the N-terminal and helicase domains, are necessary for these functions. In addition, the N and C termini of NS1 are required for activation of viral promoter P38. By comparison with the structural and biochemical data from other parvoviruses, we identified potential DNA-interacting amino acid residues from canine parvovirus NS1. The role of the identified amino acids in NS1 binding dynamics was studied by mutagenesis, fluorescence recovery after photobleaching, and computer simulations. Mu…
PRELIMINARY STUDY ON QUANTIFICATION OF aS1-CASEIN VARIANTS IN GIRGENTANA GOAT BREED BY DIRECT CHROMATOGRAPHIC ANALYSIS OF MILK
2012
Goat αs1-casein is a highly polymorphic protein, coded by CSN1S1 gene. Nowadays, several alleles were identified and associated with different levels of αs1-casein in goat milk. Polymorphisms at αs1-casein locus have been shown to affect not only the quantity of this casein in goat milk, but also the structural and nutritional characteristics (hypoallergenic properties) and technological properties of the milk (1). The aim of this work was to separate and quantify the most common allelic variants of αs1-casein in milk of Girgentana goat breed, a Sicilian autochthonous breed, and to evaluate the effect of αs1-casein polymorphisms on casein content. The CSN1S1 A/01, B/E, F, and N alleles were…
Toward Mechanistic Design of Surrogate Buffers for Dissolution Testing of pH-Dependent Drug Delivery Systems
2020
The in vivo dissolution of enteric-coated (EC) products is often overestimated by compendial in vitro dissolution experiments. It is of great interest to mimic the in vivo conditions as closely as possible in vitro in order to predict the in vivo behavior of EC dosage forms. The reason behind this is the overly high buffering capacity of the common compendial buffers compared to the intestinal bicarbonate buffer. However, a bicarbonate-based buffer is technically difficult to handle due to the need for continuous sparging of the media with CO2 to maintain the desired buffer pH. Therefore, bicarbonate buffers are not commonly used in routine practice and a non-volatile alternative is of inte…
Semblanza de José Antonio Ayala Pérez
2014
José Antonio Ayala Pérez (1935-2014).
Herbalists, traditional healers and pharmacists: a view of the tuberculosis in Ghana
2014
This paper is the result of a visit by Brazilian researchers to Ghana, with the aim of improving understanding of the relationship between traditional healers and conventional health practices, specifically in relation to tuberculosis. Through this exploratory visit, this group of researchers promoted by the Edital Pro Africa (CNPq) had an opportunity to learn about, reflect on, and discuss the different social, economic and cultural realities and contexts that have led to the different health conditions and forms of healthcare in Ghana. Besides the direct relationship between the social and economic conditions of the country and the health of its population, it was also concluded that ther…
Primary omental tumor with ultrastructural features of cellular schwannoma and absence of S-100 antigen reactivity.
1989
Summary We report a primary well-delimited, large mesenchymal omental neoplasm which appeared in a 58 year old man without neurofibromatous traces. The histological and ultrastructural features were consistent with a Schwann cell origin. However, repeated immunohistochemical reactions failed to demonstrate protein S-100 antigen reactivity in the neoplasic cells, the latter only expressing vimentin. The differential diagnosis with hemangiopericytoma is proposed.
LOFT - A large observatory for x-ray timing
2010
The high time resolution observations of the X-ray sky hold the key to a number of diagnostics of fundamental physics, some of which are unaccessible to other types of investigations, such as those based on imaging and spectroscopy. Revealing strong gravitational field effects, measuring the mass and spin of black holes and the equation of state of ultradense matter are among the goals of such observations. At present prospects for future, non-focused X-ray timing experiments following the exciting age of RXTE/PCA are uncertain. Technological limitations are unavoidably faced in the conception and development of experiments with effective area of several square meters, as needed in order to…
Deformation Quantization: Genesis, Developments and Metamorphoses
2002
We start with a short exposition of developments in physics and mathematics that preceded, formed the basis for, or accompanied, the birth of deformation quantization in the seventies. We indicate how the latter is at least a viable alternative, autonomous and conceptually more satisfactory, to conventional quantum mechanics and mention related questions, including covariance and star representations of Lie groups. We sketch Fedosov's geometric presentation, based on ideas coming from index theorems, which provided a beautiful frame for developing existence and classification of star-products on symplectic manifolds. We present Kontsevich's formality, a major metamorphosis of deformation qu…
Granular chains for the assessment of thermal stress in slender structures
2015
Slender beams subjected to compressive stress are common in civil and mechanical engineering. The rapid in-situ measurement of this stress may prevent structural anomalies. In this paper, we describe the coupling mechanism between highly nonlinear solitary waves (HNSWs) propagating along an L-shaped granular system and a beam in contact with the granular medium. We evaluate the use of HNSWs as a tool to measure stress in thermally loaded structures and to estimate the neutral temperature, i.e. the temperature at which this stress is null. We investigated numerically and experimentally one and two L-shaped chains of spherical particles in contact with a prismatic beam subjected to heat. We f…