Search results for "S1"
showing 10 items of 755 documents
Algebraic Quantization, Good Operators and Fractional Quantum Numbers
1995
The problems arising when quantizing systems with periodic boundary conditions are analysed, in an algebraic (group-) quantization scheme, and the ``failure" of the Ehrenfest theorem is clarified in terms of the already defined notion of {\it good} (and {\it bad}) operators. The analysis of ``constrained" Heisenberg-Weyl groups according to this quantization scheme reveals the possibility for new quantum (fractional) numbers extending those allowed for Chern classes in traditional Geometric Quantization. This study is illustrated with the examples of the free particle on the circumference and the charged particle in a homogeneous magnetic field on the torus, both examples featuring ``anomal…
The Reasonable Effectiveness of Mathematical Deformation Theory in Physics
2019
This is a brief reminder, with extensions, from a different angle and for a less specialized audience, of my presentation at WGMP32 in July 2013, to which I refer for more details on the topics hinted at in the title, mainly deformation theory applied to quantization and symmetries (of elementary particles).
Testing the stage-discharge relationship of a sharp crested sluice gate deduced by the momentum equation for a free-flow condition
2018
Abstract In this paper the stage-discharge relationship of a sharp crested sluice gate is deduced by applying the momentum equation for a free flow condition. The theoretically deduced stage-discharge formula was then calibrated using experimental flume data obtained in previous investigations carried out for a free-flow condition. The deduced stage–discharge relationship is characterized by a momentum coefficient which is empirically estimated by the ratio between the height of the orifice and the water depth in the section upstream the gate. The relative errors are always less than or equal to - 10% to +10% and 71.4% of the errors are less than or equal to ± 2%.
Effect of Acoustic Wave Reflections on Space Charge Measurements with PEA Method
2018
The Pulsed Electro-Acoustic (PEA) method is the most used technique for space charge detection in solid dielectrics. The methodology is largely employed in the field of High Voltage Direct Current (HVDC) transmission and is based on the detection of acoustic waves generated by charges vibration. One of the most common problems arising during the detection is the presence of multiple reflections taking place due to the presence of means discontinuity in the different PEA cell components. This reflection phenomenon, if not well taken into account, could cause incorrect interpretation of the PEA output signal. It is easy to understand that a simulation model is a basic tool to understand the w…
Development of the wide field imager for Athena
2015
The WFI (Wide Field Imager) instrument is planned to be one of two complementary focal plane cameras on ESA's next X-ray observatory Athena. It combines unprecedented survey power through its large field of view of 40 arcmin x 40 arcmin together with excellent count-rate capability (>= 1 Crab). The energy resolution of the silicon sensor is state-of-the-art in the energy band of interest from 0.2 keV to 15 keV, e.g. the full width at half maximum of a line at 6 keV will be <= 150 eV until the end of the nominal mission phase. This performance is accomplished by using DEPFET active pixel sensors with a pixel size of 130 μm x 130 μm well suited to the on-axis angular resolution of 5 arcsec of…
Analytical description of lobster eye and similar multi-foil optics
2015
Analytical equations describing lobster eye optical parameters on dependence on its geometric parameters are presented. The paper partially gives review of main previously known results. At next, the paper gives new results discussing parameters, that were not included to previously published models but may be significant. The results are applicable for a Schmidt as well as for an Angel lobster eye and for some related multi-foil systems.
The optical blocking filter for the ATHENA wide field imager: Ongoing activities towards the conceptual design
2015
ATHENA is the L2 mission selected by ESA to pursue the science theme "Hot and Energetic Universe" (launch scheduled in 2028). One of the key instruments of ATHENA is the Wide Field Imager (WFI) which will provide imaging in the 0.1-15 keV band over a 40'x40' large field of view, together with spectrally and time-resolved photon counting. The WFI camera, based on arrays of DEPFET active pixel sensors, is also sensitive to UV/Vis photons. Optically generated electron-hole pairs may degrade the spectral resolution as well as change the energy scale by introducing a signal offset. For this reason, the use of an X-ray transparent optical blocking filter is needed to allow the observation of all …
Current Evidence, Challenges, and Opportunities of Physiologically Based Pharmacokinetic Models of Atorvastatin for Decision Making
2021
Atorvastatin (ATS) is the gold-standard treatment worldwide for the management of hypercholesterolemia and prevention of cardiovascular diseases associated with dyslipidemia. Physiologically based pharmacokinetic (PBPK) models have been positioned as a valuable tool for the characterization of complex pharmacokinetic (PK) processes and its extrapolation in special sub-groups of the population, leading to regulatory recognition. Several PBPK models of ATS have been published in the recent years, addressing different aspects of the PK properties of ATS. Therefore, the aims of this review are (i) to summarize the physicochemical and pharmacokinetic characteristics involved in the time-course o…
Physiologically-Based Pharmacokinetic/Pharmacodynamic Model of MBQ-167 to Predict Tumor Growth Inhibition in Mice
2020
MBQ-167 is a dual inhibitor of the Rho GTPases Rac and Cdc42 that has shown promising results as an anti-cancer therapeutic at the preclinical stage. This drug has been tested in vitro and in vivo in metastatic breast cancer mouse models. The aim of this study is to develop a physiologically based pharmacokinetic/pharmacodynamic (PBPK-PD) model of MBQ-167 to predict tumor growth inhibition following intraperitoneal (IP) administration in mice bearing Triple Negative and HER2+ mammary tumors. PBPK and Simeoni tumor growth inhibition (TGI) models were developed using the Simcyp V19 Animal Simulator. Our developed PBPK framework adequately describes the time course of MBQ-167 in each of the mo…
FAMILY PIERIDE (LEPIDOPTERA, PIERIDAE) AND EVOLUTION OVER TIME IN FOREST GROVE SIBIU (SIBIU, ROMANIA)
2015
Transylvania, with its geographic location, flora and fauna is a well defined region, whereby, in addition to many common elements with neighboring areas, there are also some characteristic species, which so far continue to maintain the "endemic" status. The previous decades were very important for the development of Lepidopterological research in Sibiu and Transylvania, in the postwar years. The richness of insect fauna and especially the numerous species of Lepidoptera as of its existing knowledge of this group of insects stimulated the curiosity of many researchers since the middle of the 19th century.