Search results for "S1"
showing 10 items of 755 documents
DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY
2015
The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…
Nonstationary flow surface theory for modeling the viscoplastic behaviors of soils
2016
Abstract This paper presents a three-dimensional elastic viscoplastic model that can describe the time-dependent behaviors of soft clays. The constitutive model is formulated based on the nonstationary flow surface theory and incorporates new developments, including (i) an improved definition of the nonstationary flow surface that is capable of capturing the stress–strain behaviors under different loading paths, (ii) a unique stress–strain—viscoplastic-strain-rate equation that is able to explicitly describe the nonstationary flow surface, and (iii) a final stable state concept that identifies the final equilibrium state at the end of creep and stress relaxation, which is also used to simpl…
A critical evaluation of caplacizumab for the treatment of acquired thrombotic thrombocytopenic purpura
2020
Introduction: Acquired thrombotic thrombocytopenic purpura (aTTP) is a thrombotic microangiopathy caused by inhibitory autoantibodies against ADAMTS13 protein. Until recently, the combination of plasma exchange (PEX) and immunosuppression has been the standard front-line treatment in this disorder. However, aTTP-related mortality, refractoriness, and relapse are still a matter of concern. Areas covered: The better understanding of the pathophysiological mechanisms of aTTP has allowed substantial improvements in the diagnosis and treatment of this disease. Recently, the novel anti-VWF nanobody caplacizumab has been approved for acute episodes of aTTP. Caplacizumab is capable to block the adh…
COVID-19 as a Potential Trigger for Immune Thrombotic Thrombocytopenic Purpura and Reason for an Unusual Treatment: A Case Report
2021
AbstractImmune thrombotic thrombocytopenic purpura (iTTP) is a rare autoimmune disorder characterized by severely reduced activity of the von Willebrand factor (VWF)-cleaving protease ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13) due to autoantibodies. This leads to the development of pathogenic multimers of VWF, causing a thrombotic microangiopathy with decreased number of platelets, hemolysis, and life-threatening tissue ischemia of mostly brain, heart, and kidneys. Standard treatment of iTTP involves daily plasma exchange to remove ultra large multimers of VWF, inhibitors, substituting ADAMTS13, and the accompaniment of an immunosuppressive …
Combination of D0 measurements of the top quark mass
2017
We present a combination of measurements of the top quark mass by the D0 experiment in the lepton+jets and dilepton channels. We use all the data collected in Run I (1992--1996) at $\sqrt s=1.8$ TeV and Run II (2001--2011) at $\sqrt s=1.96$ TeV of the Tevatron $p \bar{p}$ collider, corresponding to integrated luminosities of 0.1 fb$^{-1}$ and 9.7 fb$^{-1}$, respectively. The combined result is: $m_t = 174.95 \pm0.40\,{\rm(stat)} \pm 0.64\,{\rm(syst)}\,{\rm{GeV}}=174.95 \pm 0.75 \, {\rm{GeV}}$.
A genetic algorithm for combined topology and shape optimisations
2003
A method to find optimal topology and shape of structures is presented. With the first the optimal distribution of an assigned mass is found using an approach based on homogenisation theory, that seeks in which elements of a meshed domain it is present mass; with the second the discontinuous boundaries are smoothed. The problem of the optimal topology search has an ON/OFF nature and has suggested the employment of genetic algorithms. Thus in this paper a genetic algorithm has been developed, which uses as design variables, in the topology optimisation, the relative densities (with respect to effective material density) 0 or 1 of each element of the structure and, in the shape one, the coord…
Whole body vibrations during field operations in the vineyard
2013
Human exposure to mechanical vibration can be a significant risk factor for exposed workers and this also occurs in the agricultural sector, in particular with reference to the driver of the tractor during field operations. The aim of this paper is the evaluation of Whole Body Vibrations for the operator driving tractors during the field operations in the vineyard. The experimental tests were performed using a wheeled and a track-laying tractor. They were coupled to four different machines: rototilling (RT), chisel plough (CP), flail mowers (FM) and vibro farmer (VF). Two homogeneous plots of vineyard, about 200 m long, were identified different only for slope: 0% and 30%. The tests were pe…
Noise levels of a track-laying tractor during field operations in the vineyard
2013
Noise in agriculture is one of the risk factors to be taken into account in the assessment of the health and safety of workers; in particular, it is known that the tractor is a source of high noise. The Italian Low Decree 81/2008 defined the requirements for assessing and managing noise risk identifying a number of procedures to be adopted at different noise levels to limit workers exposure. This paper concerns the analysis of the noise risk arising from the use of a tracklaying tractor during field operations carried out in the vineyard. The objective of this study was to evaluate the noise level that comes close to the ear of the operator driving the tractor measuring the values of equiva…
Pre-requisites of successful strategic electronic coordination : the moderation effect of the ownership mechanism of inter-organisational information…
2017
In this paper, we attempt to explain how the ownership mechanism of an interorganisational information system (IOS) may impact strategic information exchange (electronic coordination) induced by specific investments in the IOS. Recent research and practice show that heavy investments in IOSs demonstrate mixed results with respect to their impact on the electronic coordination. Consequently, the search of additional factors is needed to help and explain under what circumstances the IOS investments for strategic purposes become beneficial for the companies in a buyersupplier dyad. Transaction cost economics (TCE) and the hostage model are used as a framework for the research. 198 observations…
Analysing longitudinal turbulence intensity in vegetated channels
2007
Vegetation altering hydrodynamic conditions of an open channel flow controls the exchanges of sediment, nutrients and contaminants. In this paper the turbulence structure of open-channel flow over a flexible grass vegetation is investigated. Velocity measurements were carried out, in a rectangular flume, using a 2D-ADV (Acoustic Doppler Velocimeter) for different values of stem concentration, water discharge, and bed slope. The experimental results showed that: 1) the maximum value of the longitudinal turbulence intensity occurs at a water depth close to the bent vegetation height; 2) the turbulence intensity damps for increasing values of the stem concentration; 3) above the vegetation hei…