Search results for "S1"

Molecular Determinants of the Response of Tumor Cells to Boswellic Acids

2011

Frankincense (Boswellia serrata, B. carterii) is used as traditional remedy to treat inflammatory diseases. The molecular effects of the active ingredients, the boswellic acids, on the immune system have previously been studied and verified in several clinical studies. Boswellic acids also inhibit cancer cell growth in vitro and in vivo. The molecular basis of the cytotoxicity of boswellic acids is, however, not fully understood as yet. By mRNA-based microarray, COMPARE, and hierarchical cluster analyses, we identified a panel of genes from diverse functional groups, which were significantly associated with sensitivity or resistance of a- or b-boswellic acids, such as transcription factors,…

Early warning thresholds for partially saturated slopes in volcanic ashes

2013

Rainfall-induced landslides in steep soil slopes of volcanic origin are a major threat to human lives and infrastructure. In the context of constructing early warning systems in regions where extensive data on landslide occurrences and associated rainfall are inexistent, physically-based tools offer the possibility to establish thresholds for measurable field quantities. In this paper, a combined finite element infinite slope model is presented to study the transient hydraulic response of volcanic ash slopes to a series of rainfall events and to estimate seasonal safety factors. Furthermore, analytical considerations of partially saturated infinite slopes are made to define capillary stress…

A pedotransfer function for estimating the soil erodibility factor in Sicily

2009

The soil erodibility factor, K, of the Universal Soil Loss Equation (USLE) is a simple descriptor of the soil susceptibility to rill and interrill erosion. The original procedure for determining K needs a knowledge of soil particle size distribution (PSD), soil organic matter, OM, content, and soil structure and permeability characteristics. However, OM data are often missing and soil structure and permeability are not easily evaluated in regional analyses. The objective of this investigation was to develop a pedotransfer function (PTF) for estimating the K factor of the USLE in Sicily (south Italy) using only soil textural data. The nomograph soil erodibility factor and its associated firs…

GREEN ECONOMY - THE ECONOMY OF THE FUTURE

2013

This paper defines the concept of "green economy", presents the main international organizations that deal the green economy. Are provided details of the most significant principles, objectives and actions of the concept of green economy. At the European level there is "The 2020 strategy ", which shows that Europe's economy should be an economy that knows how to manage resources efficiently and reduce carbon emissions. There are currently a number of basic laws for the green economy. Forest ecosystems are part of the green economy and the forest products industry are very important because they are renewable, recyclable and biodegradable. Thus forests are a fundament of the green economy, t…

Increased carrier peptide stability through ph adjustment improves insulin and pth(1-34) delivery in vitro and in vivo rather than by enforced carrie…

2020

Oral delivery of therapeutic peptides is hampered by their large molecular size and labile nature, thus limiting their permeation across the intestinal epithelium. Promising approaches to overcome the latter include co-administration with carrier peptides. In this study, the cell-penetrating peptide penetratin was employed to investigate effects of co-administration with insulin and the pharmacologically active part of parathyroid hormone (PTH(1-34)) at pH 5, 6.5, and 7.4 with respect to complexation, enzymatic stability, and transepithelial permeation of the therapeutic peptide in vitro and in vivo. Complex formation between insulin or PTH(1-34) and penetratin was pH-dependent. Micron-size…

Tietotekniikan valtakunnallisten oppisisältöjen toteutuminen Keski-Suomen peruskoulujen opetuskäytänteissä

2017

Tutkimus sai alkunsa kiinnostuksesta uusia Perusopetuksen opetussuunnitelman perusteita kohtaan. Vuonna 2014 hyväksytty POPS asettui erityisesti tieto- ja viestintätekniikan opetuksen osalta vastaamaan perusopetuksessa havaittuihin puutteisiin ja ongelmiin. Tutkimuksen tarkoituksena oli selvittää mitä uusia sisältöjä POPS14 tuo tietotekniikan opetukseen sekä kuinka noiden sisältöjen opetus toteutuu koulujen arjessa. Tutkimuksessa tunnistettiin tyypilliset ja yleisesti käytössä olevat TVT:n opetusmenetelmät ja niitä pyrittiin kuvailemaan laadullisen tutkimuksen keinoin. Tavoitteeseen päästiin lähinnä Opetushallituksen julkaisuihin kohdistuneen kirjallisuuskatsauksen, Keski-Suomen peruskouluj…

Pharmacokinetics of Intravitreal Anti-VEGF Drugs in Age-Related Macular Degeneration

2019

Intravitreal administration of anti-vascular endothelial growth factor (VEGF) antibodies has become the standard treatment for Age-Related Macular Degeneration; however, the knowledge of their pharmacokinetics is limited. A comprehensive review of the preclinical and clinical pharmacokinetic data that were obtained in different studies with intravitreal bevacizumab, ranibizumab, and aflibercept has been conducted. Moreover, the factors that can influence the vitreous pharmacokinetics of these drugs, as well as the methods that were used in the studies for analytical determination, have been exposed. These anti-VEGF drugs present different charge and molecular weights, which play an importan…

Nuclear reorganization and dynamics during canine parvovirus infection

2007

DEVELOPMENT TRENDS OF BIOGAS

2015

All over the world, researches are made in order to improve the technologies, the operational and process stability and performance of biogas plants, because the world markets for biogas increased considerably in Europe and all over the world. In this paper we studied the most important parameters related to a biogas plant, starting from the ecologic landfill of Cristian, Sibiu, a landfill which storages industrial and household waste. In this respect, we studied operational parameters, such as organic load and hydraulic retention time, and parameters for evaluation of a biogas plant. Also, we made a case study concerning the evaluation of used waters in the landfill described above under t…

Testing the shape-similarity hypothesis between particle-size distribution and water retention for Sicilian soils

2012

Application of the Arya and Paris (AP) model to estimate the soil water retention curve requires a detailed description of the particlesize distribution (PSD) but limited experimental PSD data are generally determined by the conventional sieve-hydrometer (SH) method. Detailed PSDs can be obtained by fitting a continuous model to SH data or performing measurements by the laser diffraction (LD) method. The AP model was applied to 40 Sicilian soils for which the PSD was measured by both the SH and LD methods. The scale factor was set equal to 1.38 (procedure AP1) or estimated by a logistical model with parameters gathered from literature (procedure AP2). For both SH and LD data, procedure AP2 …