Search results for "S5"
showing 10 items of 201 documents
The Impact of Smart City Initiatives on Human Rights : A Qualitative Research Study
2019
Master's thesis Information Systems IS501 - University of Agder 2019 Context:A smart city is a concept where municipalities use ICTto increase efficiency, sustainability and quality of life forits citizensand city operations. Smart city initiatives useIoT technologies, enabled by ICTs to gather large volumesof unstructured data,known as BigData.The aim of any smart city initiativeisto increase thequality of lifein acity, but posesa threat tocitizens privacy, security andfreedom of expressiondue to the large volumes of databeing collected in smart cities,potentially violatingfundamental rightsin theUniversal Declaration of Human Rights.Purpose:This thesis investigatesthe connection between s…
Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b
2021
HCV is an important cause of hepatocellular carcinoma (HCC). HCV NS5A domain-1 interacts with cellular proteins inducing pro-oncogenic pathways. Thus, we explore genetic variations in NS5A domain-1 and their association with HCC, by analyzing 188 NS5A sequences from HCV genotype-1b infected DAA-naïve cirrhotic patients: 34 with HCC and 154 without HCC. Specific NS5A mutations significantly correlate with HCC: S3T (8.8% vs. 1.3%, p = 0.01), T122M (8.8% vs. 0.0%, p <
Practices in research, surveillance and control of neglected tropical diseases by One Health approaches: A survey targeting scientists from French-sp…
2021
One health (OH) approaches have increasingly been used in the last decade in the fight against zoonotic neglected tropical diseases (NTDs). However, descriptions of such collaborations between the human, animal and environmental health sectors are still limited for French-speaking tropical countries. The objective of the current survey was to explore the diversity of OH experiences applied to research, surveillance and control of NTDs by scientists from French-speaking countries, and discuss their constraints and benefits. Six zoonotic NTDs were targeted: echinococcoses, trypanosomiases, leishmaniases, rabies, Taenia solium cysticercosis and leptospiroses. Invitations to fill in an online q…
Implementing an institutional change in a regional context : A case study of telemedicine implementation and diffusion in Agder
2018
Master's thesis Information Systems IS501 - University of Agder 2018 High life expectancy, aging population and an increasing chronic diseases generates new challenges for the current global healthcare (Brouard, Bardo, Vignot, Bonnet, & Vignot, 2014). Public agencies and business corporates have shown interest inadvances technological research and innovation projects to remedy the problem. Innovating in public sector is highly challengingand results shouldn’t be taken for granted (Dacin, Goodstein, & Scott, 2002). Further, there is a lack of understanding how public innovations are created (Sørensen & Torfing, 2011). Theoretically the thesis builds on two strands of theories: institutional …
Treatment outcomes in hepatitis C virus genotype 1a infected patients with and without baseline NS5A resistance‐associated substitutions
2020
Background&aims The presence of baseline resistance-associated substitutions (RASs) reduced sustained virologic response (SVR) rates in chronic hepatitis C virus (HCV) genotype 1a infected patients treated with Elbasvir/Grazoprevir (EBR/GZR). This study aimed to evaluate the frequency of NS5A RASs and treatment outcomes in patients for whom EBR/GZR was intended. Methods We sequenced NS5A in 832 samples from German genotype1a-infected DAA-naive patients population-based, which were collected in the European Resistance Database. Treatment outcomes and clinical parameters were evaluated in 519 of these patients retrospectively. Results Overall, 6.5% of patients harbored EBR-specific NS5A RASs …
Resistance-associated substitutions in patients with chronic hepatitis C virus genotype 4 infection
2020
Data on the prevalence of resistance-associated substitutions (RASs) and their implications for treatment with direct-acting antivirals (DAAs) are sparse in European patients with HCV genotype 4. This study investigated RASs before and after DAA failure in different genotype 4 subtypes and evaluated retreatment efficacies. Samples of 195 genotype 4-infected patients were collected in the European Resistance Database and investigated for NS3, NS5A and NS5B RASs. Retreatment efficacies in DAA failure patients were analysed retrospectively. After NS5A inhibitor (NS5Ai) failure, subtype 4r was frequent (30%) compared to DAA-naive patients (5%) and the number of NS5A RASs was significantly highe…
Patient-to-patient transmission of hepatitis C virus (HCV) during colonoscopy diagnosis
2010
Abstract Background No recognized risk factors can be identified in 10-40% of hepatitis C virus (HCV)-infected patients suggesting that the modes of transmission involved could be underestimated or unidentified. Invasive diagnostic procedures, such as endoscopy, have been considered as a potential HCV transmission route; although the actual extent of transmission in endoscopy procedures remains controversial. Most reported HCV outbreaks related to nosocomial acquisition have been attributed to unsafe injection practices and use of multi-dose vials. Only a few cases of likely patient-to-patient HCV transmission via a contaminated colonoscope have been reported to date. Nosocomial HCV infecti…
Hvilke faktorer kan forklare ansattes bruk av sikkerhetstiltak på mobile enheternår de er ute på farten?
2018
Masteroppgave informasjonssystemer IS501 - Universitetet i Agder 2018 Kontekst:Brukeren er ofte omtalt som den største trusselen motinformasjonssikkerhet i virksomheter. I dag bruker de flesteen eller fleremobile enheter på jobben. Sammen med mobile enheter kommer også nye farer knyttet til informasjonssikkerhet,ogdet er derfor svært viktig at ansatte bruker anbefalte sikkerhetstiltaknår de erpå jobben, men også utenfor virksomheten.Målet med studien er å analyserehvilkefaktorersomkan forklare bruk av sikkerhetstiltakpå mobile enheterutenfor organisatoriske rammer («ute på farten»). Målsetting:Denne avhandlingen rapporterer resultaterfra en studie der det er brukt elementer fra kjenteatferd…
Towards an understanding of big data analytics as a weapon for competitive performance
2017
Master's thesis Information Systems IS501 - University of Agder 2017 Context: Big data has in the recent years been an area of interest among innovative organizations and has started to become a major priority for organizations in general, either through their own big data departments or by purchasing big data analyses from suppliers. Big data analytics means more knowledge from more data sources and is by many prophesied to be a contributing source of big change in how organizations receive their intelligence. Purpose: This thesis investigates the connection between big data and competitive performance. This connection could be explained through the following two paths; 1) how big data ana…
Organizational culture as a primary driver for utilizing big data analytics in organizations
2019
Master's thesis Information Systems IS501 - University of Agder 2019 Context:During this last decade we have witnessed a wave of digital disruption, where big data has had a central part. This has gotten many organizations to pay attention and investing in analytic tools for big data. Big data analytics can provide organizations with more knowledge from more data sources that can have a big impact on how organizations act. Many of the organizations that have purchased big data analytics have failed to derive benefits from it and this is demonstratedin the literature. Organizational culture is mentioned as being an important part of achieving success when adopting big data.Purpose: The purpo…