Search results for "SAC"
showing 10 items of 3337 documents
Revival cristologico e Vangeli
2008
Alpha-1-antitrypsin-induced inhibition of complement-dependent phagocytosis.
1981
Abstract In a previous investigation, inhibition of complement-dependent rosette formation by alpha1-antitrypsin (α1-AT) was observed, and it was demonstrated that α1-AT interacts through its carbohydrate portion with C3 and its fragments. In the present study, the effect of α1-AT on the complement-receptor-mediated phagocytosis by human peripheral blood monocytes was examined. Purified α1-AT inhibited in a dose-dependent manner phagocytosis of C3-carrying yeast particles. Inhibition was selective, concerned only C3-receptor-mediated phagocytosis, neither Fc-receptor-mediated phagocytosis nor uptake of untreated yeast particles was blocked by α1-AT. It was demonstrated that α1-AT exerted it…
Effect of imidazo[1,2-α]pyrimidine derivatives on leukocyte function
2001
Objective and Design: A series of six imidazo[1,2-α]pyrimidine (IP) derivatives were evaluated for their effects on leukocyte functions in vitro as well as on the inflammatory response induced by zymosan in the mouse air pouch.¶Materials and Subjects: Human neutrophils and murine peritoneal macrophages were used for in vitro assays. Mouse air pouch was performed in Swiss mice.¶Treatment: Test compounds were incubated with either human neutrophils or mouse peritoneal macrophages at concentrations not showing cytotoxic effects. For in vivo experiments, IPs were injected into the air pouch.¶Methods: Elastase and myeloperoxidase release, superoxide generation and LTB4 production were assayed in…
Lipid A-Induced Responses In Vivo
2009
The lipid A analogs used in preclinical studies and clinical trials are not naturally-occurring forms of lipid A; they are synthetic molecules produced to be less toxic than lipid A itself and they do not reproduce the effects of natural lipid A molecules especially in vivo. The responses induced by lipid A analogs are summarized in this chapter: their fate in the blood stream and their toxicity as well as the lipid A tolerance and the tumor immune responses they induce. Lipid A is not found in the mammalian organism under normal circumstances so its use in cancer therapy raises important questions as to its different effects in vivo and its toxicity, particularly in cancer patients. Lipid …
Wicked behavior and catastrophes in the Roman world: believes, religiosity and politic
2014
La religión es un componente tan esencial en las sociedades del Mundo Antiguo que de su correcta difusión y de la perfecta realización de los cultos depende la disposición de los dioses y, con ella, el devenir de los acontecimientos. En la vida práctica, esto se transmite en dos ámbitos: la élite, el grupo encargado de la celebración de los ritos no puede cometer errores en su tarea; y el pueblo, todos los habitantes del territorio tienen que adherirse a la religión “estatal”. Cuando en alguno de estos dos elementos se producen fallos, se suceden prodigios y catástrofes de cualquier tipo. Frente a esto, la solución consiste en: castigo del causante o causantes de la impiedad y reparación de…
Estilo de liderazgo en un órgano de control externo. El caso de la Sindicatura de Comptes de la Comunitat Valenciana
2019
Este artículo analiza los patrones de liderazgo en la Sindicatura de Comptes de la Comunitat Valenciana durante sus tres décadas de existencia. Como organización pública de relevancia estatutaria ha experimentado una modernización sostenida para adecuar sus estructuras al entorno sociopolítico. Uno de los factores que explican el calado de los cambios de la Sindicatura es el liderazgo y el modelo directivo (Bass 1985) de sus síndicos mayores en las distintas fases del ciclo de vida (Levitt, 1965; Adizes, 1994). Por consiguiente, partiendo de un estudio longitudinal de la caracterización de los liderazgos de los síndicos mayores entre 1985-2015 se expondrán los principales rasgos que han car…
Los estilos de liderazgo de la Policía Local de la Comunidad Valenciana: Una aproximación desde la Teoría del Liderazgo Transformacional
2012
Tomando como base la Teoría de Liderazgo Transformacional (Bass, 1985), se estudian las conductas que componen los estilos de liderazgo y su relación con tres variables de resultado: la eficacia del líder, la satisfacción con el líder y el esfuerzo extra de los subordinados; así como el aumento de los efectos (augmentation effect) del liderazgo transaccional cuando además se utiliza el liderazgo transformacional. La muestra es representativa del universo de policías locales de la Comunidad Valenciana (España) y está compuesta por 975 policías locales (828 hombres y 147 mujeres) pertenecientes a las plantillas de 42 localidades y que son dirigidos por 42 jefes. Los resultados muestran jefes …
Voluntary distance running prevents TNF-mediated liver injury in mice through alterations of the intrahepatic immune milieu
2017
AbstractPhysical activity confers a broad spectrum of health benefits. Beyond the obvious role in metabolically driven diseases, the role of physical activity in acute liver injury is poorly explored. To study the role of physical activity in acute liver injury, a novel model of voluntary distance running in mice was developed and mice were subjected to acute liver injury induced by N-galactosamine (GalN) and lipopolysaccharide (LPS). Analyses included histological stains, immunoblotting, qRT-PCR and FACS analysis. Voluntary distance running increased to an average of 10.3 km/day after a learning curve. Running lead to a decrease in the absolute numbers of intrahepatic CD4+ T and B lymphocy…
An Artificial Neural Network Assisted Dynamic Light Scattering Procedure for Assessing Living Cells Size in Suspension
2020
Dynamic light scattering (DLS) is an essential technique used for assessing the size of the particles in suspension, covering the range from nanometers to microns. Although it has been very well established for quite some time, improvement can still be brought in simplifying the experimental setup and in employing an easier to use data processing procedure for the acquired time-series. A DLS time series processing procedure based on an artificial neural network is presented with details regarding the design, training procedure and error analysis, working over an extended particle size range. The procedure proved to be much faster regarding time-series processing and easier to use than fitti…
Photoaffinity Labeling and Photoaffinity Cross-Linking of Phosphofructokinase-1 from Saccharomyces cerevisiae by 8-Azidoadeninenucleotides
2001
Phosphofructokinase-1 from Saccharomyces cerevisiae is composed of four alpha- and four beta-subunits, each of them carrying catalytic and regulatory bindings sites for MgATP. In this paper, various photoaffinity labels, such as 8-azidoadenosine 5'-triphosphate, 8-azido-1,N6-ethenoadenosine 5'-triphosphate, and 8-N3-3'(2')-O-biotinyl-8-azidoadenosine 5'-triphosphate have been used to study their interaction with the enzyme in the dark and during irradiation. All nucleotidetriphosphates function as phosphate donor forming fructose 1,6-bisphosphate from fructose 6-phosphate. However, the kinetic analysis revealed distinctly differences between them. Photolabeling causes a decrease in enzyme a…