Search results for "SAF"

Ensuring the Consistency of Biosimilars

2017

Background: Biological products are subject to constant reappraisal by regulatory agencies and pharmaceutical companies once they have entered the market, since every improvement in their manufacturing process has the potential to alter the basic properties of these molecules. Methods: Narrative review focusing on scientific literature as well as legal documents from regulatory agencies. Results: Evaluating the impact of each manufacturing change of these drugs requires rigorous analyses in proportion to the anticipated risk of inducing more or less molecular micro-heterogenicity. There are currently more than 30 biosimilars of TNF-alpha blockers at different stages of testing, each with a …

Patterns of Safety Incidents in a Neonatal Intensive Care Unit

2021

Introduction: Safety incidents preceding manifest adverse events are barely evaluated in neonatal intensive care units (NICUs). This study aimed at identifying frequency and patterns of safety incidents in our NICU.Methods: A 6-month prospective clinical study was performed from May to October 2019 in a German 10-bed level III NICU. A voluntary, anonymous reporting system was introduced, and all neonatal team members were invited to complete paper-based questionnaires following each particular safety incident. Safety incidents were defined as safety-related events that were considered by the reporting team member as a “threat to the patient's well-being” which “should ideally not occur agai…

IMPACT OF THE "COMUNICAT" METHODOLOGY ON THE IMPROVEMENT OF THE "EFFECTIVE ORAL COMMUNICATION" STUDENT OUTCOME OF THE STUDENTS OF THE MASTER IN FOOD …

2019

[EN] During academic course 2017-2018 the Comunica't methodology was created to help students to self-learn all the skills needed to master the areas of domain of the general student outcome effective oral communication. After two academic years of implementation, the goal of this work is to analyse the degree of contribution of this methodology to development of the "Effective Oral Communication students outcome of students that followed the methodology during the subject Audits of Food Safety and Quality Systems, belonging to the Master in Food Safety and Quality Management. To this end, at the beginning of the subject, students were asked to present a topic related to the subject and eva…

The effects of a medical hypnotherapy on clothing industry employees suffering from chronic pain.

2013

Abstract Background Problems associated with pain in several body regions due to work-related musculoskeletal disorders (WRMDs), repetitive movement and negative stress at work are quite common in many manufacturing industries of Latvia, int.al. clothing industry. The aim of this study was to evaluate efficiency of the psychotherapeutic intervention using medical hypnotherapy (MH) program for mind-body relaxation with pain-blocking imagery, cognitive restructuring of unpleasant physical and emotional experience. Methods 300 sewers and 50 cutters with chronic pain were involved in the study. Self-rated WRMDs symptoms, pain intensity and interference were assessed using the extended version o…

Validity of a Questionnaire for the Assessment of Work-related Musculoskeletal Symptoms and Physical Demands

2011

Fundamentos: En las intervenciones de ergonomía participativa es frecuente utilizar cuestionarios autoadministrados para obtener información acerca de los daños y riesgos ergonómicos percibidos por los trabajadores. El objetivo de este estudio es evaluar la validez de un cuestionario diseñado para su utilización en este tipo de programas. Métodos: Participaron 35 trabajadores voluntarios de diez empresas de Valencia y Alicante. El trabajo de campo se realizó en 2009. Se siguieron tres estrategias: análisis de repetibilidad en dos vueltas del cuestionario, comparación de las respuestas al cuestionario (primera vuelta) con la información obtenida mediante observación directa de los puestos de…

Relationships of leisure-time physical activity and work ability between different occupational physical demands in adult working men

2019

Purpose: Leisure-time physical activity (LTPA) is known to be associated with positive health benefits, but the role of occupational physical demands remains inconsistent. The purpose of the current study was to assess the relationship between LTPA and work ability in different occupational physical activity (OPA) levels between young adult men. - Methods: We performed physical activity measurements in work and leisure time with the long version of International Physical Activity Questionnaire (IPAQ) and work ability with the Work Ability Index (WAI) in 921 Finnish employed male volunteer participants. The participants were divided into LTPA tertiles I ( 28 MET-h/week) and OPA tertiles I (0…

The relationship between personalities and self-report positive driving behavior in a Chinese sample.

2018

Driving behaviors play an important role in accident involvement. Concretely speaking, aberrant driving behaviors would cause more accidents, and oppositely positive driving behaviors would promote to build safety traffic environment. The main goals of this study were to explore the positive driving behavior and its relationship with personality in a Chinese sample. A total of 421 licensed drivers (286 male and 135 female) from Beijing, China completed the Positive Driver Behavior Scale (PDBS), the Driver Behavior Questionnaire (DBQ), the Dula Dangerous Driving Index (DDDI) and the Big Five Inventory (BFI) on a voluntary and anonymous basis. The results showed that the Chinese version of th…

Le procedure di audit della sicurezza sul progetto e sulle infrastrutture in esercizio

2010

Radiation effects in nitride read-only memories

2010

Abstract We report on the influence of different types of radiation on the nitride read-only memories (NROM®). The memory cells were irradiated by light ions (Boron), X-rays and γ-rays. Memory transistor parameters, such as threshold voltage and subthreshold drain leakage were studied as a function of the accumulated radiation dose and compared to the as-programmed (-erased) devices parameters. Their time evolution was registered in the range from few hours up to 5 months after the irradiation. The NROM® cells showed good radiation robustness up to high accumulated doses. Sufficient program margin (difference of threshold voltage in the programmed state and the read-out voltage level) remai…

Efficacy of raw implementation and reduction dose protocols in CT colonoscopy: a single centre 4 years retrospective review

2015

Aims and objectives Methods and materials Results Conclusion Personal information References