Search results for "SAF"
showing 10 items of 2183 documents
Conservare per ricostruire. Il caso del Parco Archeologico e Paesaggistico di Agrigento
2021
L'evoluzione dell'idea di paesaggio ha prodotto una trasformazione dello stesso concetto che, da una sfera legata all'approccio estetico ha portato ad una accezione più complessa, richiamando quella della Convenzione Europea del Paesaggio, all'idea di una parte di territorio, come percepita dall'uomo, il cui carattere deriva dall'interazione di fattori naturali e umani. Le riflessioni presentate nel presente articolo sono fatte analizzando un paesaggio particolare, la Valle dei Templi di Agrigento. Esse portano a guardare al progetto, partendo da un'analisi profonda, con una nuova visione che guarda all'area archeologica non più come un singolo bene ma come un elemento di un sistema a rete …
Posterior chamber phakic intraocular lenses after penetrating keratoplasty.
2009
Purpose To evaluate the efficacy, predictability, and safety of a phakic posterior chamber intraocular Collamer lens (ICL) after penetrating keratoplasty (PKP). Setting Fernandez-Vega Ophthalmological Institute, Oviedo, Spain. Methods A myopic or toric ICL was implanted after PKP in eyes unable to wear glasses or contact lenses and for which corneal laser surgery was contraindicated. The uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), refractive error, and endothelial cell count were recorded preoperatively and 24 months postoperatively. Results Preoperatively, the 15 eyes had myopia from −2.00 to −17.00 diopters (D) or astigmatism from −1.50 to −7.00 D. …
Chapter 22: Assuring the quality, safety and efficacy of HPV vaccines: The scientific basis of regulatory expectations pre- and post-licensure
2006
The potential of human papillomavirus (HPV) vaccines will only be realized if the vaccine candidates under development prove to be safe and effective and can be consistently produced to define quality standards. Whilst the responsibility for delivering a safe and effective product rests with the vaccine producer, a vaccine requires a license to allow it to be placed on the market. Licensure is based on an evaluation of the safety and efficacy profile of a vaccine candidate by national regulatory authorities, ideally on the basis of internationally agreed, science-based specifications and procedures. For vaccines, these international specifications are developed by the World Health Organizat…
Precipitation responses to ENSO and IOD in the Maldives: Implications of large-scale modes of climate variability in weather-related preparedness
2020
Abstract This research seeks to address the extent to which indices of large-scale modes of climate variability (El Nino Southern Oscillation (ENSO) and Indian Ocean Dipole (IOD)) can be linked to physical differences in the local mean and extreme rainfall conditions experienced in the Maldives in order to suggest implications for disaster risk reduction (DRR). While some significant differences in precipitation metrics do occur at the local level between different phases of the large-scale modes of climate variability studied, they do not occur for all sites studied. While the constrained availability of historical meteorological data in the region is a limiting factor in this analysis, th…
Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) – …
2013
International audience; Background & AimsIn phase III trials, the safety profile of triple therapy (pegylated interferon/ribavirin with boceprevir or telaprevir) seems to be similar in HCV treatment-experienced cirrhotic and non-cirrhotic patients, but few cirrhotics were included. We report the week 16 safety and efficacy analysis in a cohort of compensated cirrhotics treated in the French Early Access Programme.Methods674 genotype 1 patients, prospectively included, received 48 weeks of triple therapy. The analysis is restricted to 497 patients reaching week 16.ResultsA high incidence of serious adverse events (40.0%), and of death and severe complications (severe infection or hepatic dec…
High efficacy and safety of triple therapy in HCV genotype 1 and moderate fibrosis: a multicenter study of clinical practice in Spain.
2015
Background and rational. Telaprevir-based therapy (TBT) has been extensively evaluated in clinical trials. So we designed a study to compare the efficacy and safety of TBT between patients with moderate fibrosis and those suffering from advanced fibrosis in clinical practice. A multicenter observational and ambispective study was conducted. It included 582 patients with chronic hepatitis C genotype 1, 214 with fibrosis F2, and 368 with F3/F4 (F3: 148; F4: 220). Results. The mean patient age was 55 years, 67% male. Type of prior response was 22% naive, 57% relapsers, and 21% partial/null responders, 69% had high viral load (> 800,000 IU/mL). HCV genotypes were 1a (19%), 1b (69%), and 1 (12%)…
Predictors of serious adverse events and non-response in cirrhotic patients with primary biliary cholangitis treated with obeticholic acid
2022
Background & Aims Obeticholic acid (OCA) has recently been restricted in patients with primary biliary cholangitis (PBC) with "advanced cirrhosis" because of its narrow therapeutic index. We aimed to better define the predicting factors of hepatic serious adverse events (SAEs) and non-response in cirrhotic patients undergoing OCA therapy. Methods Safety and efficacy of treatment were evaluated in a cohort of consecutive PBC cirrhotic patients started with OCA. OCA response was evaluated according to the Poise criteria. Risk factors for hepatic SAEs and non-response were reported as risk ratios (RR) with 95% confidence intervals (CIs). Results One hundred PBC cirrhotics were included, 97…
Load capacity and deflection of fire-resistant steel beams
1990
The methodology of defining safety of constructions in fire has not yet been sufficiently verified and agreed upon. This paper includes calculation results for steel beams, which prove that the ultimate load-bearing capacity predicted by plastic design theory, which is valid in engineering calculations, is not sufficient for determining the critical temperature. The reason is that this temperature tends to be limited in some cases by large deflections of beams in fire.
Michael Field's Sapphism : an Ontology of the Feminine in "Long Ago" (1889)
2018
This article examines the valuable contribution that Katherine Bradley and her niece Edith Cooper made to the vast tradition of queer Sapphism in Long Ago (1889), their first volume of poetry published under the collaborative pseudonym of Michael Field. Taking as my starting point the well-established assumption among contemporary critics that this volume represents an original instance of lesbian writing, I seek to argue that Long Ago not only appropriates and celebrates the figure of Sappho as a lesbian archetype, it also proposes a subversive gender theory that conceptualises the feminine as the essential principle of vitalism, the masculine as the very representation of death, and homoe…
Analysis of a Collapsed Long-Span Reinforced Concrete Roof in South Italy: Design Mistakes and Material Degradation
2020
In 2004, during ordinary maintenance work, consisting of waterproofing a building located in the south of Italy, the long-span (14.5 m) in situ RC roof partially collapsed. The building, constructed in 1950, was in service as a cinema until 1967 and then utilized as a school until 1985. Lastly, it was a hotel until 2000. In 2004, when the building was not in service and was undergoing maintenance work, it partially collapsed under dead load. After the collapse, which involved a large portion of the roof, several beams, and two columns, the Italian court nominated an official technical consultant to investigate the direct and related causes of the failure. After the main causes were identifi…