Search results for "SAFER"
showing 10 items of 38 documents
VISMapper: ultra-fast exhaustive cartography of viral insertion sites for gene therapy
2017
The possibility of integrating viral vectors to become a persistent part of the host genome makes them a crucial element of clinical gene therapy. However, viral integration has associated risks, such as the unintentional activation of oncogenes that can result in cancer. Therefore, the analysis of integration sites of retroviral vectors is a crucial step in developing safer vectors for therapeutic use. Here we present VISMapper, a vector integration site analysis web server, to analyze next-generation sequencing data for retroviral vector integration sites. VISMapper can be found at: http://vismapper.babelomics.org . Because it uses novel mapping algorithms VISMapper is remarkably faster t…
1653 – The developemnt of adaptive and maladaptive patterns of internet use among european adolescents at risk for internet addictive behaviors: a gr…
2013
Introduction Full findings from the European Commission funded EU-NET-ADB study (Safer Internet Programme) will be presented. Objectives Empirical findings that elucidate the development of an internet addictive behaviour are still incomplete. This is also related to risk as well as protective factors of internet use. Here a process oriented approach to identify underlying conditions of an internet addictive behaviour was chosen. Aims The aim of the study is to enhance the knowledge and understanding of underlying processes which lead to situation were internet addictive behaviour can evolve. Methods In total 124 in-depth interviews were conducted with adolescents with an age of 14-17 year.…
Expert Drivers' Prospective Thinking-Aloud to Enhance Automated Driving Technologies - Investigating Uncertainty and Anticipation in Traffic.
2020
Abstract Current automated driving technology cannot cope in numerous conditions that are basic daily driving situations for human drivers. Previous studies show that profound understanding of human drivers’ capability to interpret and anticipate traffic situations is required in order to provide similar capacities for automated driving technologies. There is currently not enough a priori understanding of these anticipatory capacities for safe driving applicable to any given driving situation. To enable the development of safer, more economical, and more comfortable automated driving experience, expert drivers’ anticipations and related uncertainties were studied on public roads. First, dri…
Safer chemicals using less animals: kick-off of the European ONTOX project
2021
The 3Rs concept, calling for replacement, reduction and refinement of animal experimentation, is receiving increasing attention around the world, and has found its way to legislation, in particular in the European Union. This is aligned by continuing high-level efforts of the European Commission to support development and implementation of 3Rs methods. In this respect, the European project called "ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment" was recently initiated with the goal to provide a functional and sustainable solution for advancing human risk assessment of chemicals without the use of animal…
Biodegradability Prediction of Fragrant Molecules by Molecular Topology
2016
Biodegradability is a key property in the development of safer fragrances. In this work we present a green methodology for its preliminary assessment. The structure of various fragrant molecules is characterized by computing a large set of topological indices. Those relevant to biodegradability are selected by means of a hybrid stepwise selection method to build a linear classifier. This model is compared with a more complex artificial neural network trained with the indices previously found. After validation, the models show promise for time and cost reduction in the development of new, safer fragrances. The methodology presented could easily be adapted to many quasi-big data problems in R…
Safer Reinforcement Learning for Agents in Industrial Grid-Warehousing
2020
In mission-critical, real-world environments, there is typically a low threshold for failure, which makes interaction with learning algorithms particularly challenging. Here, current state-of-the-art reinforcement learning algorithms struggle to learn optimal control policies safely. Loss of control follows, which could result in equipment breakages and even personal injuries.
The Rise of Distributed Artificial Intelligence Through Shared Data and Cloud Solutions
2021
Decision-makers of present times encounter influence by an ever-increasing emotional condition created by social media, market trends, experience, and historical facts. The concept of mixed human and artificial intelligence is one of the most underrated business drivers today, and conspiracy theories, fixed mindset, and legacy systems are slowing down collective evolution. This paper intends to contribute to the everyday awareness of data sharing through cloud solutions and services. It opens a wide range of possibilities for new solutions and insights that endorse a collaborative culture where a growth mindset paired with transparency and ethics reduces time-to-value in businesses, governm…
Les droits de préemption de la SAFER
2016
SAFER = société d'aménagement foncier et d'établissement rural; National audience; La 4e de couverture indique : "Le droit de préemption de la SAFER est un mécanisme fondamental du droit de l'espace rural. Il plane au-dessus des mutations relatives à des biens ruraux, des terres, des exploitations agricoles ou forestières. Redoutable autant que redouté, l'instrument n'a cessé d'étendre son empire et de se sophistiquer au fil des lois. Le présent ouvrage explore, de manière inédite, tous les arcanes du droit de préemption de la SAFER. La première partie traite de son domaine d'application : quelles sont les opérations que la SAFER peut court-circuiter en faisant valoir ses prérogatives d'ord…
SAFER et sociétés : trois mariages et un enterrement
2017
International audience; La loi n° 2017-348 du 20 mars 2017 relative à la lutte contre l’accaparement des terres agricoles renforce le pouvoir de surveillance des SAFER sur les appropriations réalisées par les sociétés, mais échoue à étendre leur droit de préemption aux mutations partielles de parts sociales.
Uncertainty and cross-border banking flows
2019
Abstract While global uncertainty—measured by the VIX—has proven to be a robust global “push” factor of international capital flows, there has been no systematic study assessing the role of uncertainty in driving bilateral capital flows. This paper examines the effects of higher country-specific uncertainty on cross-border banking flows using data from the Bank for International Settlements Locational Banking Statistics. The bilateral structure of this data allows disentangling supply factors from demand factors, thereby helping identify the effect of higher uncertainty on cross-border banking flows from other confounding factors. The results of this analysis suggest that: (i) uncertainty i…