Search results for "SAFETY"
showing 10 items of 1959 documents
Preventive maintenance versus cost of repairs in asset management: An efficiency analysis in wastewater treatment plants
2020
Abstract The operation and management of Wastewater Treatment Plants (WWTPs) is of paramount importance to guarantee the sustainability of water resources. Just like any other production process, wastewater treatment process involves different costs, such as: energy, personnel, maintenance and reagents. Regarding maintenance costs, they have become an issue of great concern to many operators in the last years. Maintaining the facilities in good condition ensures the proper performance of these infrastructures and reduces the risk of failures. It should be known that equipment breakdowns imply an increase in operating costs, with a high risk of generating an environmental damage due to the m…
A phase IB, multicenter, open-label study to assess the safety, tolerability, and efficacy of the pleiotropic pathway modifier CC122 administered ora…
2017
379 Background: CC122 is a novel cereblon-modulating agent with multiple biologic activities including potent immunomodulatory and antiangiogenic effects. CC-122 binding to cereblon promotes ubiquitination and subsequent degradation of lymphoid transcription factors Ikaros and Aiolos resulting in activation of T cells. Methods: Following establishment of oral CC122 3 mg daily (QD) as the MTD in phase 1a (Blood 122:2905 2013), an expansion cohort of advanced Hepatocellular Carcinoma (HCC) subjects was enrolled. All subjects had progressed on or were intolerant to sorafenib. Efficacy was assessed per RECIST 1.1 criteria. Results: As of Jan. 13, 2016, 25 advanced HCC subjects were enrolled. T…
On the Difference Between Necessary and Unnecessary Glances Away From the Forward Roadway : An Occlusion Study on the Motorway
2019
Objective The present study strove to distinguish traffic-related glances away from the forward roadway from non-traffic-related glances while assessing the minimum amount of visual information intake necessary for safe driving in particular scenarios. Background Published gaze-based distraction detection algorithms and guidelines for distraction prevention essentially measure the time spent looking away from the forward roadway, without incorporating situation-based attentional requirements. Incorporating situation-based attentional requirements would entail an approach that not only considers the time spent looking elsewhere but also checks whether all necessary information has been sampl…
Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials?
2016
Intraspinal stem cell (SC) transplantation represents a new therapeutic approach for amyotrophic lateral sclerosis (ALS) clinical trials. There are considerable difficulties in designing future efficacy trials, some related to the field of ALS and some that are specific to SCs or the mode of delivery. In October 2015, the most controversial points on SC transplantation were addressed during an international workshop intended to bring together international SC and ALS researchers in a public discussion on a topic for which expertise is limited. During the meeting, a discussion was started on the basic structure of the ideal clinical trial testing the efficacy and safety of SC transplantation…
Psychotropic drugs and driving: prevalence and types
2013
Background Some psychotropic medications (e.g., benzodiazepines, sedative antidepressants, etc.) may impair cognitive and psychomotor functions and, therefore, endanger traffic safety (Ravera, Br J Clin Pharmacol, 72(3):505–513, 2011). They affect detection, registration, and information processing, problem solving, and decision-making processes, and they also affect emotional and social aspects. The objective of this research was to clarify three closely related issues that are significant for traffic safety: the prevalence of psychotropic drugs on driving, the most frequently used psychotropic drugs to treat depression, anxiety, insomnia, or any tranquilizers (whether it is a medical pres…
Bis(hydroxyphenyl)methane-bisphenol F-metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes
2011
author cannot archive publisher's version/PDF; International audience; Bisphenol F (BPF) is present in the environment and as a contaminant of food. Humans may, therefore, be exposed to BPF, and an assessment of this risk is required. BPF has been shown to have genotoxic and endocrine-disruptor properties in a human hepatoma cell line (HepG2), which is a model system for studies of xenobiotic toxicity. In this study, we investigated the ability of HepG2 cells to biotransform BPF, because metabolism may affect the observed effects of BPF, and we compared this metabolic capacity with that of human hepatocytes. Cells were incubated for 24 hours with [(3)H]-BPF. The culture medium was then conc…
On the relationship between occlusion times and in-car glance durations in simulated driving
2023
Drivers have spare visual capacity in driving, and often this capacity is used for engaging in secondary in-car tasks. Previous research has suggested that the spare visual capacity could be estimated with the occlusion method. However, the relationship between drivers’ occlusion times and in-car glance duration preferences has not been sufficiently investigated for granting occlusion times the role of an estimate of spare visual capacity. We conducted a driving simulator experiment (N = 30) and investigated if there is an association between drivers’ occlusion times and in-car glance durations in a given driving scenario. Furthermore, we explored which factors and variables could explain t…
Evaluation of Roundabout Safety Performance through Surrogate Safety Measures from Microsimulation
2018
The paper presents a microsimulation-based approach for roundabout safety performance evaluation. Based on a sample of Slovenian roundabouts, the vehicle trajectories exported from AIMSUN and VISSIM were used to estimate traffic conflicts using the Surrogate Safety Assessment Model (SSAM). AIMSUN and VISSIM were calibrated for single-lane, double-lane and turbo roundabouts using the corresponding empirical capacity function which included critical and follow-up headways estimated through meta-analysis. Based on calibration of the microsimulation models, a crash prediction model from simulated peak hour conflicts for a sample of Slovenian roundabouts was developed. A generalized linear model…
MCMI-III Profiles of Convicted Contact Sexual Offenders: A Cluster Analysis
2019
As suggested by previous research, the study of personality traits among sexual offenders could be an important consideration in the understanding of sexual offending. This study aims to explore the possibility of classifying sexual offenders according to their personality profiles. Based on the MCMI-III scores of 97 convicted contact sexual offenders, a cluster hierarchical analysis was performed. Next, the groups were characterized according to their sociodemographic and criminological variables and significant differences between them were sought. The two clusters found did not show different MCMI-III prototypical personality profiles, and both groups only varied in the degree of general…
Safety self-efficacy and internal locus of control as mediators of safety motivation – Randomized controlled trial (RCT) study
2019
Abstract Behavioral factors play a fundamental role in preventing occupational injuries and accidents. Previous studies have shown that engagement in safety behavior is influenced by workers’ safety motivation. However, understanding of the cognitive factors that contribute to safety motivation is lacking. In this study, we examine internal safety locus of control and safety self-efficacy as mediators of the effects of a safety intervention on safety motivation. In 2016, 464 students from eight vocational schools participated in a school-based cluster randomized, controlled intervention study conducted in Finland. In the multiple mediation model investigated using structural equation modeli…