Search results for "SAGE"
showing 10 items of 1373 documents
Evaluation of polyalkylcyanoacrylate nanoparticles as a potential drug carrier: preparation, morphological characterization and loading capacity.
1993
Some physicochemical behaviours were investigated of polyethyl- (PECA) and polyisobutylcyanoacrylate (PICA), which, in recent years, have been proposed as nanoparticle colloidal systems for drug carrying. We observed the influence of preparation conditions, such as pH value and surfactant concentration, on parameters such as particle size and polymer molecular weight. Lower operating pH values (0-2) resulted in smaller nanoparticles than those prepared at pH 5.5. The polymer molecular weight was also a function of pH: low molecular weight at low pH and vice-versa. The surfactant concentration positively influenced main particle size and polymer molecular weight. These trends were independen…
Neutron ESR dosimetry through ammonium tartrate with low Gd content.
2014
This paper continues analyses on organic compounds for application in neutron dosimetry performed through electron spin resonance (ESR). Here, the authors present the results obtained by ESR measurements of a blend of ammonium tartrate dosemeters and gadolinium oxide (5 % by weight). The choice of low amount of Gd is due to the need of improving neutron sensitivity while not significantly influencing tissue equivalence. A study of the effect of gadolinium presence on tissue equivalence was carried out. The experiments show that the neutron sensitivity is enhanced by more than an order of magnitude even with this small additive content. Monte Carlo simulations on the increment of energy rele…
Transmission Efficiency of the SAGE Spectrometer Using GEANT4
2013
The new SAGE spectrometer allows simultaneous electron and γ-ray in-beam studies of heavy nuclei. A comprehensive GEANT4 simulation suite has been created for the SAGE spectrometer. This includes both the silicon detectors for electron detection and the germanium detectors for γ-ray detection. The simulation can be used for a wide variety of tests with the aim of better understanding the behaviour of SAGE. A number of aspects of electron transmission are presented here.
A Novel Disintegration Tester for Solid Dosage Forms Enabling Adjustable Hydrodynamics.
2016
A modified in vitro disintegration test device was designed that enables the investigation of the influence of hydrodynamic conditions on disintegration of solid oral dosage forms. The device represents an improved derivative of the compendial PhEur/USP disintegration test device. By the application of a computerized numerical control, a variety of physiologically relevant moving velocities and profiles can be applied. With the help of computational fluid dynamics, the hydrodynamic and mechanical forces present in the probe chamber were characterized for a variety of device moving speeds. Furthermore, a proof of concept study aimed at the investigation of the influence of hydrodynamic condi…
First-passage problem for nonlinear systems under Lévy white noise through path integral method
2016
In this paper, the first-passage problem for nonlinear systems driven by $$\alpha $$ -stable Levy white noises is considered. The path integral solution (PIS) is adopted for determining the reliability function and first-passage time probability density function of nonlinear oscillators. Specifically, based on the properties of $$\alpha $$ -stable random variables and processes, PIS is extended to deal with Levy white noises with any value of the stability index $$\alpha $$ . Application to linear and nonlinear systems considering different values of $$\alpha $$ is reported. Comparisons with pertinent Monte Carlo simulation data demonstrate the accuracy of the results.
Efficient solution of the first passage problem by Path Integration for normal and Poissonian white noise
2015
Abstract In this paper the first passage problem is examined for linear and nonlinear systems driven by Poissonian and normal white noise input. The problem is handled step-by-step accounting for the Markov properties of the response process and then by Chapman–Kolmogorov equation. The final formulation consists just of a sequence of matrix–vector multiplications giving the reliability density function at any time instant. Comparison with Monte Carlo simulation reveals the excellent accuracy of the proposed method.
Les acquisitions en mathématiques à l'école primaire : des compétences au centre des apprentissages
2007
07065 - Actes à paraître; National audience; Cette communication met l'accent sur les compétences mies en oeuvre par les élèves à l'école élémentaire dans le domaine des mathématiques. Des analyses longitudinales conduites sur de larges échantillons permettent de mettre en évidence le rôle central de certaines compétences de mathématiques (évaluéesdans les épreuves d'évaluation nationales) dans les processus d'apprentissage et leur évolution au cours des années. Ainsi, les habiletés en calcul mental apparaissent comme des éléments très prédictifs de la réussite ultérieure. En outre, les acquisitions réalisées dans le domaine numérique avant l'entrée au CP sont elles-aussi de bons prédicteur…
La fabrication des artisans : socialisation et processus de médiation dans l'apprentissage de la menuiserie
2012
This doctoral thesis in Communication Sciences offers to rethink the question of transmission of manual trades, in the context of contemporary craft industry in France. We analyse the classical dualism between “manual” and “nonmanual”, and go further with a theoretical approach of intelligence derived from Janet and Jousse. We also base our analysis on the studies about socialization, especially from Dubar, so we can involve a non-determinist model of transmitting manual crafts. In order to recognize the importance of working with materials, tools, in occupational socialization, we propose to look at its sequence as a “process of mediation” and to describe its communication device, inspired…
Chemotherapy for advanced gastric cancer
2017
Background Gastric cancer is the fifth most common cancer worldwide. In "Western" countries, most people are either diagnosed at an advanced stage, or develop a relapse after surgery with curative intent. In people with advanced disease, significant benefits from targeted therapies are currently limited to HER-2 positive disease treated with trastuzumab, in combination with chemotherapy, in first-line. In second-line, ramucirumab, alone or in combination with paclitaxel, demonstrated significant survival benefits. Thus, systemic chemotherapy remains the mainstay of treatment for advanced gastric cancer. Uncertainty remains regarding the choice of the regimen. Objectives To assess the effica…