Search results for "SAMPLE"
showing 10 items of 2270 documents
Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population.
2015
Evidence gained from animals and humans suggests that the encephalic opioid system might be involved in the development of drug addiction through its role in reward. Our aim is to assess the influence of genetic variations in the opioid receptor mu 1 on alcohol and tobacco consumption in a Spanish population. 763 unrelated individuals (465 women, 298 men) aged 18-85 years were recruited between October 2011 and April 2012. Participants were requested to answer a 35-item questionnaire on tobacco and alcohol consumption, as well as to complete the AUDIT and Fagerström tests. Individuals were genotyped for three polymorphisms in the opioid receptor mu 1 (OPRM1) gene, using a TaqMan® protocol. …
A Colorimetric Membrane-Based Sensor with Improved Selectivity towards Amphetamine
2021
Due to their simplicity, speed and low cost, chemical spot tests are increasingly demanded for the presumptive identification of illicit drugs in a variety of contexts such as point-of-care assistance or prosecution of drug trafficking. However, most of the colorimetric reactions used in these tests are, at best, drug class selective. Therefore, the development of tests based on chemical reactions with improved discrimination power is of great interest. In this work, we propose a new colorimetric assay for amphetamine (AMP) based on its reaction with solutions of alkaline gold bromide to form an insoluble yellow–orange derivative. The resulting suspensions are then filtered onto nylon membr…
Minimum effective dose for antidepressants - an obligatory requirement for antidepressant drug evaluation?
1996
Extensive clinical trials are required for registration and approval of new antidepressants in most countries including the requirement that a minimal effective dose should be determined. The rationale for this requirement is to avoid the use of unnecessarily high doses. The implication is that for every antidepressant, a dose exists that serves as a threshold, below which all doses are not effective or are clearly less effective in treating a major depressive episode. Dose titration and fixed dose studies are used to determine the minimal effective dose, but both strategies have limitations and often do not allow definite establishment of a clear-cut minimal effective dose. The effort of e…
Simultaneous determination of traditional and emerging illicit drugs in sediments, sludges and particulate matter
2015
An analytical method for determining traditional and emerging drugs of abuse in particulate matter, sewage sludge and sediment has been developed and validated. A total of 41 drugs of abuse and metabolites including cocainics, tryptamines, amphetamines, arylcyclohexylamines, cathinones, morphine derivatives, pyrrolidifenones derivatives, entactogens, piperazines and other psychostimulants were selected. Samples were ultrasound extracted with McIlvaine buffer and methanol, and the extracts were cleaned up by solid phase extraction (SPE) using Strata-X cartridges. Drugs were eluted using methanol and methanol-dichloromethane and determined by liquid chromatography tandem mass spectrometry. Th…
Determinants affecting consumers' attention to fish eco-labels in purchase decisions: a cross-country study
2022
PurposeThe purpose of this study was to investigate the role of consumer altruism and other socio-cultural factors in predicting how much attention consumers pay to seafood eco-labels.Design/methodology/approachThe empirical investigation was carried out by administering an online questionnaire to a sample of Italian and Spanish people from December 2019 to April 2020. After carrying out the principal component analysis procedure, the work made use of an ordinal logistic regression.FindingsBoth Italian and Spanish consumers with an altruistic attitude, who feel that food produced in a sustainable way can protect the environment and workers, appear more likely to take an eco-label into accou…
Impressing my friends: The role of social value in green purchasing attitude for youthful consumers
2021
Abstract Prior studies predominantly use cross-sectional designs to determine effects of pro-environmental beliefs on green purchasing attitudes, thereby limiting the possibility for causal inferences and examining mediation effects. We overcome these gaps by adopting a two-wave longitudinal design to test a moderated-mediation model that draws on consumer choice theory, positing that the effect of implicit pro-environmental beliefs on green purchasing attitudes is mediated by perceived social value from buying green, while the relationship between pro-environmental beliefs and perceived social value is moderated by perceived inconvenience of buying green. Findings from a sample of Polish y…
"Barnehagen er ingen søndagsskole ..." Religion i barnehager med forskjellige livssynsvedtekter
2021
How do a sample of headteachers and pedagogical leaders understand the parts of the learning area ‘ethics, religion and philosophy’ (ERF) related to religion and religious heritage and tradition in early childhood education? And how do they implement them in practice? We have interviewed employees from 19 kindergartens in Agder and Oslo, and analyzed relevant pedagogical documents, to get answers. The informants came from both public kindergartens and private kindergartens with special objectives. In the private kindergartens, most informants expressed that religion and religious heritage and tradition were integrated in the pedagogical day to day work, with use of a large degree of a didac…
The role of individual processes and learning environment in the prediction of grades in a sample of Norwegian students
2018
Student grades are traditionally used to evaluate academic achievement in higher education. A review of previous research indicates a relatively clear tendency to adopt either an individual or contextual approach in exploring this subject. The present study represents an attempt to simultaneously examine effects of individual variables and learning environment on academic achievements as measured in grades. The study adopts a quantitative approach and reports data collected from students enrolled in early childhood education in a mid-sized university in Norway. Results of a stepwise hierarchical regression demonstrate that individual variables (e.g. nonmandatory school attendance, self-effi…
On the Asymmetric Recognition of Good and Bad News in France, Germany and the United Kingdom
2001
We investigate whether accounting systems recognise bad news more promptly in earnings than good news, where news is proxied by changes in share price. The analysis is based on a sample of firm/years drawn from France, Germany, and the UK during 1990 to 1998. These three countries are the originators of three distinct legal traditions. Previous studies have argued that asymmetric recognition, one manifestation of conservative accounting, is sensitive to legal background and history. We find that in all three countries the contemporaneous association between earnings and returns is much stronger for bad news (i.e. when price changes are negative) than for good news, and although the results …
A European multicentre evaluation of detection and typing methods for human enteroviruses and parechoviruses using RNA transcripts
2020
Polymerase chain reaction (PCR) detection has become the gold standard for diagnosis and typing of enterovirus (EV) and human parechovirus (HPeV) infections. Its effectiveness depends critically on using the appropriate sample types and high assay sensitivity as viral loads in cerebrospinal fluid samples from meningitis and sepsis clinical presentation can be extremely low. This study evaluated the sensitivity and specificity of currently used commercial and in‐house diagnostic and typing assays. Accurately quantified RNA transcript controls were distributed to 27 diagnostic and 12 reference laboratories in 17 European countries for blinded testing. Transcripts represented the four human EV…