Search results for "SARS"

Obstetric-Neonatal Care during Birth and Postpartum in Symptomatic and Asymptomatic Women Infected with SARS-CoV-2: A Retrospective Multicenter Study

2022

Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/1660-4601/19/9/5482 Este artículo de investigación pertenece a la colección "COVID-19 Research". En este artículo de investigación también participan: Laura Andreu-Pejó, Cristina Martínez-Porcar, Carmen Rodríguez Gonzálvez, Patricia Torrent-Ramos, Nieves Asensio-Tomás, Yolanda Herraiz-Soler, Ramon Escuriet y Desirée Mena-Tudela. This study analyses the obstetric–neonatal outcomes of women in labour with symptomatic and asymptomatic COVID-19. A retrospective, multicenter, observational study was carried out between 1 March 2020 and 28 February 2021 in eight public hospitals in the Valencian community (Spain). The…

Minimal clinically important difference and minimal detectable change of the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0…

2020

Objectives: The aim of this study is to estimate a minimal clinically important difference (MCID) and a minimal detectable change (MDC) of the 12-item WHODAS 2.0 amongst patients with chronic musculoskeletal pain. Design: Cross-sectional cohort study. Setting: Outpatient Physical and Rehabilitation Medicine clinic. Subjects: A total of 1988 consecutive patients with musculoskeletal pain. Interventions: A distribution-based approach was employed to estimate a minimal clinically important difference, a minimal detectable change, and a minimal detectable percent change (MDC%). Results: The mean age of the patients was 48 years, and 65% were women. The average intensity of pain was 6,3 (2.0) po…

SARS-CoV-2 antibodies, serum inflammatory biomarkers and clinical severity of hospitalized COVID-19 patients

2020

Background The involvement of SARS-CoV-2 antibodies in mediating immunopathogenetic events in COVID-19 patients has been suggested. By using several experimental approaches, we investigated the potential association between SARS-CoV-2 IgGs recognizing the spike (S) protein receptor-binding domain (RBD), neutralizing antibodies (NtAb) targeting S, and COVID-19 severity. Patients and methods This unicenter, retrospective, observational study included 51 hospitalized patients (24 at the intensive care unit; ICU). A total of 93 sera from these patients collected at different time points from the onset of symptoms were analyzed. SARS-CoV-2 RBD IgGs were quantitated by ELISA and NtAb50 titers wer…

Editorial: The Challenge of New Therapeutic Approaches for Unmet Therapeutic Needs

2020

Bioactive pyrrole-based compounds with target selectivity

2020

The discovery of novel synthetic compounds with drug-like properties is an ongoing challenge in medicinal chemistry. Natural products have inspired the synthesis of compounds for pharmaceutical application, most of which are based on N-heterocyclic motifs. Among these, the pyrrole ring is one of the most explored heterocycles in drug discovery programs for several therapeutic areas, confirmed by the high number of pyrrole-based drugs reaching the market. In the present review, we focused on pyrrole and its hetero-fused derivatives with anticancer, antimicrobial, and antiviral activities, reported in the literature between 2015 and 2019, for which a specific target was identified, being resp…

miR-1207-5p Can Contribute to Dysregulation of Inflammatory Response in COVID-19 via Targeting SARS-CoV-2 RNA

2020

The present study focuses on the role of human miRNAs in SARS-CoV-2 infection. An extensive analysis of human miRNA binding sites on the viral genome led to the identification of miR-1207-5p as potential regulator of the viral Spike protein. It is known that exogenous RNA can compete for miRNA targets of endogenous mRNAs leading to their overexpression. Our results suggest that SARS-CoV-2 virus can act as an exogenous competing RNA, facilitating the over-expression of its endogenous targets. Transcriptomic analysis of human alveolar and bronchial epithelial cells confirmed that the CSF1 gene, a known target of miR-1207-5p, is over-expressed following SARS-CoV-2 infection. CSF1 enhances macr…

Assessment of SARS-CoV-2 RNA shedding in semen of 36 males with symptomatic, asymptomatic, and convalescent infection during the first and second wav…

2022

: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) receptor, angiotensin-converting enzyme 2 (ACE2), has been identified in the human testis, but the risk of transmission of SARS-CoV-2 through sexual intercourse still needs to be defined. The goal of our study was to determine if SARS-CoV-2 is detectable in the semen of patients suffering or recovering from coronavirus disease-19 (COVID-19), still testing positive at nasopharyngeal swabs but showing mild or no symptoms at the time of sampling. Detection of SARS-CoV-2 RNA in semen was performed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) and nested PCR targeting open reading frame (ORF) 1ab. Medical …

Psychosocial Risks, Work Engagement, and Job Satisfaction of Nurses During COVID-19 Pandemic

2020

Context:COVID-19 pandemic is a serious health emergency that has affected countries all over the world. Health emergencies are a critical psychosocial risk factor for nurses. In general, psychosocial risks constitute serious problems as they impact workers' health, productivity, and efficiency. Despite their importance, few studies analyze nurses' psychosocial risks during a health emergency caused by a pandemic or analyze their perception of the emergency and its relation to such risks.Objectives:To analyze the perception of COVID-19 by nurses, especially about measures, resources, and impact on their daily work. Also, to analyze these professionals' psychosocial risks and the relationship…

Analysis of antibody profile and correlation with disease severity in COVID-19 patients

2021

Antivielu atbildei ir būtiska loma cīņā ar SARS-CoV-2 infekciju un uz to noteikšanu balstās epidemioloģiskie pētījumi, kas ļauj spriest par vīrusa izplatību. Ar pašlaik pieejamo antivielu testu palīdzību var noteikt antivielas pret šī vīrusa S un N proteīniem, bet tās var veidoties arī pret citiem vīrusa antigēniem, taču to prevalence un funkcionālā loma nav zināma. Šajā darbā tika izstrādāts antigēnu mikrorindu tests, kas satur 30 SARS-CoV-2 antigēnus vai to fragmentus un ar tā palīdzību 103 COVID-19 pacientos izpētīta IgG, IgA, IgM un IgE antivielu veidošanās dinamika un prevalence. Rezultāti parādīja, ka pacientiem ar smagu un vidēji smagu slimības gaitu ir ievērojami augstāki IgG, IgA u…

Are pulsars born with a hidden magnetic field?

2015

The observation of several neutron stars in the center of supernova remnants and with significantly lower values of the dipolar magnetic field than the average radio-pulsar population has motivated a lively debate about their formation and origin, with controversial interpretations. A possible explanation requires the slow rotation of the proto-neutron star at birth, which is unable to amplify its magnetic field to typical pulsar levels. An alternative possibility, the hidden magnetic field scenario, considers the accretion of the fallback of the supernova debris onto the neutron star as responsible for the submergence (or screening) of the field and its apparently low value. In this paper …