Search results for "SCC"

Interference in Dutch–French Bilinguals : Stimulus and Response Conflict in Intra- and Interlingual Stroop

2018

Abstract. In the present manuscript, we investigate the source of congruency effects in a group of Dutch–French bilinguals. In particular, participants performed a color-identification Stroop task, in which both (first language) Dutch and (second language) French distracting color words were presented in colors. The typical finding is impaired responding when the word and color are incongruent (e.g., “red” in blue) relative to congruent (e.g., “red” in red). This congruency effect is observed for both first and second language distracting color words. The current experiment used a 2-to-1 keypress mapping manipulation, which allows one to separate stimulus conflict (i.e., conflict between w…

SALIVARY PROTEOME ANALYSIS BY 2D-PAGE AND SELDI-TOF/MS TO SEARCH POTENTIAL BIOMARKERS OF ORAL SQUAMOUS CELL CARCINOMA

2014

Aim. Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral cavity and is a neoplasia characterized by a poor prognosis. In fact, the estimated survival rate is 44% after 5 years from the diagnosis. The prognosis of the disease is significantly related to the stage in which the disease is diagnosed. Moreover the therapies are not very efficient and are so invasive, disfiguring and debilitating that in the survivors the quality of life is poor. Nowadays there is not a reliable and non-invasive method for early diagnosis of oral squamous cell carcinoma and the simple visual examination of the oral cavity is characterized by a low sensitivity and specificity, also b…

Experimental study of electrical FitzHugh-Nagumo neurons with modified excitability

2006

International audience; We present an electronical circuit modelling a FitzHugh-Nagumo neuron with a modified excitability. To characterize this basic cell, the bifurcation curves between stability with excitation threshold, bistability and oscillations are investigated. An electrical circuit is then proposed to realize a unidirectional coupling between two cells, mimicking an inter-neuron synaptic coupling. In such a master-slave configuration, we show experimentally how the coupling strength controls the dynamics of the slave neuron, leading to frequency locking, chaotic behavior and synchronization. These phenomena are then studied by phase map analysis. The architecture of a possible ne…

Peroxisome Proliferator-Activated Receptor Deficiency Increases the Risk of Maternal Abortion and Neonatal Mortality in Murine Pregnancy with or with…

2006

We assessed the implication of peroxisome proliferator-activated receptor (PPAR) alpha deficiency in pregnancy outcome and neonatal survival and in the modulation of T cell differentiation in murine diabetic pregnancy and their offspring. Pregnant wild-type (WT) and PPAR alpha-null mice of C57BL/6J genetic background were rendered diabetic by five low doses of streptozotocin. We observed that, in the absence of diabetes, PPAR alpha deficiency resulted in an increase in abortion rate, i.e. 0% in WT mice vs. 20% in PPAR alpha-null mice [odds ratio (OR) = 14.33; P = 0.013]. Under diabetic conditions, the abortion rate was enhanced, i.e. 8.3% in WT mice vs. 50% in PPAR alpha-null mice (OR = 4.2…

Coherence between brain activation and speech envelope at word and sentence levels showed age-related differences in low frequency bands

2021

Abstract Speech perception is dynamic and shows changes across development. In parallel, functional differences in brain development over time have been well documented and these differences may interact with changes in speech perception during infancy and childhood. Further, there is evidence that the two hemispheres contribute unequally to speech segmentation at the sentence and phonemic levels. To disentangle those contributions, we studied the cortical tracking of various sized units of speech that are crucial for spoken language processing in children (4.7–9.3 years old, N = 34) and adults (N = 19). We measured participants’ magnetoencephalogram (MEG) responses to syllables, words, and…

Efficacy of 5-FU topically applied on a buccal mucosal model resembling human tissue. A new chance for OSCC chemotherapy.

2008

Animer le matériel d'apprentissage du code de la route pour une meilleure compréhension et réussite à l'examen

2016

29èmes Entretiens du Centre Jacques-Cartier. Facteurs humains, technologies embarquées et numériques : quel rôle pour les politiques de sécurité routière ?, LYON, FRANCE, 21-/11/2016 - 23/11/2016; Des travaux sur l'intérêt d'animer le matériel du code de la route pour des publics en difficulté linguistique sont présentés et discutés.

Animer le matériel d'apprentissage du code de la route, une solution pour les personnes sourdes et malentendantes.

2016

Séminaire ARPEGE, PARIS, FRANCE, 05-/12/2016 - 05/12/2016; L'examen du code de la route est actuellement sources de difficultés pour la population sourde. Les supports statiques mériteraient d'être animé pour transmettre les rapport temps-vitesse distance, notions fondamentales pour transmettre les notions de sécurité routière. Les résultats de plusieurs travaux sont présentés et discutés.

The dual PI3K/mTOR inhibitor PKI-587 enhances sensitivity to cetuximab in EGFR-resistant human head and neck cancer models

2014

Background:Cetuximab is the only targeted agent approved for the treatment of head and neck squamous cell carcinomas (HNSCC), but low response rates and disease progression are frequently reported. As the phosphoinositide 3-kinase (PI3K) and the mammalian target of rapamycin (mTOR) pathways have an important role in the pathogenesis of HNSCC, we investigated their involvement in cetuximab resistance.Methods:Different human squamous cancer cell lines sensitive or resistant to cetuximab were tested for the dual PI3K/mTOR inhibitor PF-05212384 (PKI-587), alone and in combination, both in vitro and in vivo.Results:Treatment with PKI-587 enhances sensitivity to cetuximab in vitro, even in the co…

Salivary Microbiota Composition in Patients with Oral Squamous Cell Carcinoma: A Systematic Review.

2022

Background: Oral squamous cell carcinoma (OSCC) is one of the most prevalent cancers worldwide. Despite recent advances in diagnosis and treatment, in recent years, an increase in the incidence of OSCC has been registered, and the mortality rate is still high. This systematic review aims to identify a potential association between the composition of salivary microbiota and OSCC. Materials and Methods: The protocol for this study was designed following the PRISMA guidelines. Records were identified using different search engines (e.g., Medline/PubMed). Observational studies, in human subjects with histological diagnosis of OSCC, concerning the analysis of salivary microbiota, were selected. …