Search results for "SCID"
showing 10 items of 252 documents
Soil features in rookeries of Antarctic penguins reveal sea to land biotransport of chemical pollutants
2017
© The Author(s).
Ammonite dating of latest Cretaceous mosasaurid reptiles (Squamata, Mosasauroidea) from Jordan—preliminary observations
2017
Newly collected ammonoid material from the uppermost Cretaceous portion of the Muwaqqar Chalk Marl Formation exposed some 30 km southeast of the Qasr Al’Harrana area (east-central Jordan) includes medium-sized baculitids (Baculites ovatus auctorum, non Say), the sphenodiscid Libycoceras acutodorsatus (Noetling) and the pachydiscids Menuites fresvillensis (Seunes) and Pachydiscus (Pachydiscus) dossantosi (Maury). Of the two last named taxa, the former is a good marker species for the upper Maastrichtian, with records from Europe, central Chile, South India, Baluchistan (Pakistan), Australia, Madagascar and South Africa. The latter is known from the United Arab Emirates/Oman border area, from…
Northward invasion of the parasitic deer ked ( Lipoptena cervi), is there geographical variation in pupal size and development duration?
2010
SUMMARYThe deer ked (Lipoptena cervi) is a common ectoparasite of cervids. During the last decades the species has rapidly invaded in northern Europe, especially in Finland, towards the north and increased its prevalence on the moose population. Consequently, during this rapid invasion the deer ked has faced more severe climatic conditions. We studied whether pupal size (measured as pupal weight) and pupal development duration of the deer ked varies along historical invasion zones and temperature zones towards north in Finland. Moreover, we explored possible size- and gender-dependent variation in pupal development duration. We divided wild-collected pupae in respect to their origin in two …
Avian predation on a parasitic fly of cervids during winter: can host-related cues increase the predation risk?
2012
The deer ked (Lipoptena cervi) is an ectoparasitic fly on cervids that has expanded its distribution rapidly in Northern Europe. However, the regulating biotic factors such as predation remain unknown. The host-independent pupal stage of the fly lasts for several months. Blackish pupae are visible against snow, especially on the bedding sites of hosts, and are thus exposed to predators. To evaluate the role of predation on the invasion dynamics and evolution of L. cervi, we monitored pupal predation on artificial bedding sites in three geographical areas in Finland during winter. We explored: (1) possible predators; (2) magnitude of predation; and (3) whether predation risk is affected by h…
A new species of Arctoseius Thor, 1930 (Acari: Ascidae) from taiga regions of the Palaearctic, with a key to Arctoseius species of Fennoscandia, NW E…
2017
A new mesostigmatid mite species belonging to the genus Arctoseius Thor, 1930, is described based on material from subarctic coniferous forests, Finland, and Altai highlands, Russia. Arctoseius ambiguus sp. nov. is similar to Arctoseius venustulus (Berlese, 1916), but can be distinguished from the latter by its larger size, wider dorsal shield, weakly sclerotized presternal platelets, pronounced differences in the length of opisthonotal setae, and distinct punctation of the anal shield. A key for 15 Arctoseius species recorded in continental North-Western Europe (Fennoscandia) is given. The Fennoscandian fauna of Arctoseius species is rather specialised. It includes four European temperate …
Summer time predation on the obligatory off-host stage of an invasive ectoparasite
2016
SUMMARYPredation can regulate populations and strongly affect invasion success of novel prey. The deer ked (Lipoptena cervi; Linnaeus 1758) is an invasive ectoparasite of cervids that spends a long period of its life cycle outside the host. Prior to this study, virtually nothing was known about natural summer time predation on the deer ked. We aimed to evaluate the magnitude of summer time predation onL. cervipupae in different habitats and to identify potential predators. We conducted a set of field experiments, where we exposedL. cervipupae to various ground-dwelling vertebrate and invertebrate predators. The loss of pupae was monitored for different predator guilds. Three habitats of the…
Cognate HLA absence in trans diminishes human NK cell education
2016
NK cells are innate lymphocytes with protective functions against viral infections and tumor formation. Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which recognize distinct HLAs. NK cells with KIRs for self-HLA molecules acquire superior cytotoxicity against HLA– tumor cells during education for improved missing-self recognition. Here, we reconstituted mice with human hematopoietic cells from donors with homozygous KIR ligands or with a mix of hematopoietic cells from these homozygous donors, allowing assessment of the resulting KIR repertoire and NK cell education. We found that co-reconstitution with 2 KIR ligand–mismatched compartments did not alter the frequenc…
Skin-derived mesenchymal stem cells as quantum dot vehicles to tumors
2017
Dominyka Dapkute,1,2 Simona Steponkiene,1 Danute Bulotiene,1 Liga Saulite,3 Una Riekstina,3 Ricardas Rotomskis1,4 1Biomedical Physics Laboratory, National Cancer Institute, Vilnius, Lithuania; 2Institute of Biosciences, Vilnius University, Vilnius, Lithuania; 3Faculty of Medicine, University of Latvia, Riga, Latvia; 4Biophotonics Group of Laser Research Center, Faculty of Physics, Vilnius University, Vilnius, Lithuania Purpose: Cell-mediated delivery of nanoparticles is emerging as a new method of cancer diagnostics and treatment. Due to their inherent regenerative properties, adult mesenchymal stem cells (MSCs) are naturally attracted to wounds and sites of inflammation, as well as tumors.…
Circulating exosomes deliver free fatty acids from the bloodstream to cardiac cells: Possible role of CD36
2019
Regulation of circulating free fatty acid (FFA) levels and delivery is crucial to maintain tissue homeostasis. Exosomes are nanomembranous vesicles that are released from diverse cell types and mediate intercellular communication by delivering bioactive molecules. Here, we sought to investigate the uptake of FFAs by circulating exosomes, the delivery of FFA-loaded exosomes to cardiac cells and the possible role of the FFA transporter CD36 in these processes. Circulating exosomes were purified from the serum of healthy donors after an overnight fast (F) or 20 minutes after a high caloric breakfast (postprandial, PP). Western blotting, Immunogold Electron Microscopy and FACS analysis of circu…
The NSL Chromatin-Modifying Complex Subunit KANSL2 Regulates Cancer Stem-like Properties in Glioblastoma That Contribute to Tumorigenesis.
2016
KANSL2 is an integral subunit of the nonspecific lethal (NSL) chromatin-modifying complex that contributes to epigenetic programs in embryonic stem cells. In this study, we report a role for KANSL2 in regulation of stemness in glioblastoma (GBM), which is characterized by heterogeneous tumor stem-like cells associated with therapy resistance and disease relapse. KANSL2 expression is upregulated in cancer cells, mainly at perivascular regions of tumors. RNAi-mediated silencing of KANSL2 in GBM cells impairs their tumorigenic capacity in mouse xenograft models. In clinical specimens, we found that expression levels of KANSL2 correlate with stemness markers in GBM stem-like cell populations. M…