Search results for "SCS"
showing 10 items of 157 documents
CD133 as a target for colon cancer.
2012
INTRODUCTION: Recent evidence based on cancer stem cell (CSC) models, is boosting the progress of translational research and providing relevant clinical implications in many tumour types, including colorectal cancer. The current failure of standard therapies is attributed to a small fraction of the primary cell population with stem-like characteristics, such as self-renewal and differentiation. Identification of CSCs is based on two different criteria of selection: stemness-selective conditions and direct isolation based on putative stem cell markers expression. CD133, a transmembrane glycoprotein, was associated with tumor-initiating cells derived from several histological variants of tumo…
Solid film versus solution-phase charge-recombination dynamics of exTTF-bridge-C60 dyads.
2005
The charge-recombination dynamics of two exTTF-C 6 0 dyads (exTTF=9,10-bis(l,3-dithiol-2-ylidene)-9,10-dihydroanthracene), observed after photoinduced charge separation, are compared in solution and in the solid state. The dyads differ only in the degree of conjugation of the bridge between the donor (exTTF) and the acceptor (C 6 0 ) moieties. In solution, photoexcitation of the nonconjugated dyad C 6 0 -BN-exTTF (1) (BN=1,1'-binaphthyl) shows slower charge-recombination dynamics compared with the conjugated dyad C 6 0 -TVB-exTTF (2) (TVB = bisthienylvinylenebenzene) (lifetimes of 24 and 0.6 μs, respectively), consistent with the expected stronger electronic coupling in the conjugated dyad.…
Human brain organoids assemble functionally integrated bilateral optic vesicles
2021
During embryogenesis, optic vesicles develop from the diencephalon via a multistep process of organogenesis. Using induced pluripotent stem cell (iPSC)-derived human brain organoids, we attempted to simplify the complexities and demonstrate formation of forebrain-associated bilateral optic vesicles, cellular diversity, and functionality. Around day 30, brain organoids attempt to assemble optic vesicles, which develop progressively as visible structures within 60 days. These optic vesicle-containing brain organoids (OVB-organoids) constitute a developing optic vesicle's cellular components, including primitive corneal epithelial and lens-like cells, retinal pigment epithelia, retinal progeni…
In vitro and in vivo investigations of osteogenic differentiation ability of dental pulp stem cells (DPSCs) and gingival mesenchymal stem cells (GMSC…
2020
Thanks to the use of human mesenchymal stem cells (hMSCs), smart biomaterials and active biomolecules, Regenerative Medicine (RM) and Bone Tissue Engineering (BTE) can restore structure and function of injured tissues. Among the different sources of hMSCs, the oro-facial hMSCs have promising in vitro and in vivo regeneration potential; in particular, dental pulp and gingiva are valuable sources of autologous hMSCs. The aim of this PhD thesis is testing the in vitro and in vivo bone regeneration ability of hMSCs isolated from dental pulp and inflamed gingiva of periodontally-compromised teeth, up to now considered biological waste tissues and discarded during surgical procedures, on two comm…
Poly(alkylidenimine) Dendrimers Functionalized with the Organometallic Moiety [Ru(η5-C5H5)(PPh3)2]+ as Promising Drugs Against Cisplatin-Resistant Ca…
2018
Here and for the first time, we show that the organometallic compound [Ru(&eta
The long outburst of the black hole transient GRS 1716-249 observed in the X-ray and radio band
2018
We present the spectral and timing analysis of X-ray observations performed on the Galactic black hole transient GRS 1716-249 during the 2016-2017 outburst. The source was almost continuously observed with the Neil Gehrels Swift Observatory from December 2016 until October 2017. The X-ray hardness ratio and timing evolution indicate that the source approached the soft state three times during the outburst, even though it never reached the canonical soft spectral state. Thus, GRS 1716-249 increases the number of black hole transients showing outbursts with "failed" state transition. During the softening events, XRT and BAT broadband spectral modeling, performed with thermal Comptonization pl…
GW190412: Observation of a binary-black-hole coalescence with asymmetric masses
2020
LIGO Scientific Collaboration and Virgo Collaboration: et al.
Spectral Evolution of Scorpio X‐1 along its Color‐Color Diagram
2007
We analyze a large collection of RXTE archive data of the bright X‐ray source Scorpius X‐1 in order to study the broadband spectral evolution of the source for different values of the inferred mass accretion rate by selecting energy spectra from its Color‐Color Diagram. We model the spectra with the combination of two absorbed components: a soft thermal component, which can be interpreted as thermal emission from an accretion disk, and a hybrid Comptonization component, which self‐consistently includes the Fe Kα fluorescence line and the Compton reflected continuum. The presence of hard emission in Scorpius X‐1 has been previously reported, however, without a clear relation with the accreti…
Ab initiosimulations of accretion disc instability
2003
We show that accretion disks, both in the subcritical and supercritical accretion rate regime, may exhibit significant amplitude luminosity oscillations. The luminosity time behavior has been obtained by performing a set of time-dependent 2D SPH simulations of accretion disks with different values of alpha and accretion rate. In this study, to avoid any influence of the initial disk configuration, we produced the disks injecting matter from an outer edge far from the central object. The period of oscillations is 2 - 50 s respectively for the two cases, and the variation amplitude of the disc luminosity is 10^38 - 10^39 erg/s. An explanation of this luminosity behavior is proposed in terms o…
Binary evolution of PSR J1713+0747
2007
PSR J1713+0747 is a binary millisecond radio pulsar with a long orbital period (Porb ∼ 68 d) and a very low neutron star mass (M NS = 1.3 ± 0.2 M⊙). We simulate the evolution of this binary system with an accurate numerical code, which keeps into account both the evolution of the primary and of the whole binary system. We show that strong ejection of matter from the system is fundamental to obtain a mass at the end of the evolution that is within 1 - σ from the observed one, but propeller effects are almost negligible in such a system, where the accretion rate is always near to the Eddington limit. We show that there are indeed two mechanisms can account for the amount of mass loss from the…