Search results for "SCS"
showing 10 items of 157 documents
A method to constrain the neutron star magnetic field in Low Mass X-ray Binaries
2005
We describe here a method to put an upper limit to the strength of the magnetic field of neutron stars in low mass X‐ray binaries for which the spin period and the X‐ray luminosity during X‐ray quiescent periods are known. This is obtained using simple considerations about the position of the magnetospheric radius during quiescent periods. We applied this method to the accreting millisecond pulsar SAX J1808.4‐3658, which shows coherent X‐ray pulsations at a frequency of ∼ 400 Hz and a quiescent X‐ray luminosity of ∼ 5 × 1031 ergs/s, and found that B ⩽ 5 × 108 Gauss in this source. Combined with the lower limit inferred from the presence of X‐ray pulsations, this constrains the SAX J1808.4‐3…
A self-consistent approach to the reflection component in 4U 1705-44
2010
High-resolution spectroscopy has recently revealed in many neutron-star Low-Mass X-ray binaries that the shape of the broad iron line observed in the 6.4-6.97 keV range is consistently well fitted by a relativistically smeared line profile. We show here spectral fitting results using a newly developed self-consistent reflection model on XMM-Newton data of the LMXB 4U 1705-44 during a period when the source was in a bright soft state. This reflection model adopts a blackbody prescription for the shape of the impinging radiation field, that we physically associate with the boundary layer emission. © 2010 American Institute of Physics.
Colorectal Cancer Stem Cells: From the Crypt to the Clinic
2014
Since their first discovery, investigations of colorectal cancer stem cells (CSCs) have revealed some unexpected properties, including a high degree of heterogeneity and plasticity. By exploiting a combination of genetic, epigenetic, and microenvironmental factors, colorectal CSCs metastasize, resist chemotherapy, and continually adapt to a changing microenvironment, representing a formidable challenge to cancer eradication. Here, we review the current understanding of colorectal CSCs, including their origin, relationship to stem cells of the intestine, phenotypic characterization, and underlying regulatory mechanisms. We also discuss limitations to current preclinical models of colorectal …
Alginate-Agarose Hydrogels Improve the In Vitro Differentiation of Human Dental Pulp Stem Cells in Chondrocytes. A Histological Study
2021
[EN] Matrix-assisted autologous chondrocyte implantation (MACI) has shown promising results for cartilage repair, combining cultured chondrocytes and hydrogels, including alginate. The ability of chondrocytes for MACI is limited by different factors including donor site morbidity, dedifferentiation, limited lifespan or poor proliferation in vitro. Mesenchymal stem cells could represent an alternative for cartilage regeneration. In this study, we propose a MACI scaffold consisting of a mixed alginate-agarose hydrogel in combination with human dental pulp stem cells (hDPSCs), suitable for cartilage regeneration. Scaffolds were characterized according to their rheological properties, and their…
Regulation of the hDlg/hScrib/Hugl-1 tumour suppressor complex.
2008
The proper function of the Scribble tumour suppressor complex is dependent upon the correct localisation of its components. Previously we observed dynamic relocalisation of the hDlg component under conditions of osmotic stress. We now show that the other two components of the complex, hScrib and Hugl-1 display similar patterns of expression. We demonstrate, by shRNA ablation of hScrib expression, that hDlg and Hugl-1 are in part dependent upon hScrib for their correct localization. However under conditions of osmotic stress this apparent dependency no longer exists: hDlg and Hugl-1 localise to cell membranes independently of hScrib. We also demonstrate an interaction between the three compo…
Mesenchymal and Induced Pluripotent Stem Cells-Derived Extracellular Vesicles: The New Frontier for Regenerative Medicine?
2020
Regenerative medicine aims to repair damaged, tissues or organs for the treatment of various diseases, which have been poorly managed with conventional drugs and medical procedures. To date, multimodal regenerative methods include transplant of healthy organs, tissues, or cells, body stimulation to activate a self-healing response in damaged tissues, as well as the combined use of cells and bio-degradable scaffold to obtain functional tissues. Certainly, stem cells are promising tools in regenerative medicine due to their ability to induce de novo tissue formation and/or promote organ repair and regeneration. Currently, several studies have shown that the beneficial stem cell effects, espec…
Genetic parameters for somatic cell score according to udder infection status in Valle del Belice dairy sheep
2010
Unmanned aerial vehicle technology to assess the state of threatened biogenic formations: The vermetid reefs of mediterranean intertidal rocky coasts
2021
Abstract Vermetid bioconstructions are biogenic formations, built by sessile gastropod molluscs belonging to the family Vermetidae worldwide distributed, occurring in the intertidal and upper subtidal in the rocky shores. In the Mediterranean basin, they occur in complex and tridimensional structures that enhance the local biodiversity, allowing to qualify the structuring species as ecosystem engineers. Due to their ecological relevance and considerable extension along the coasts, we assessed their structural complexity using unmanned aerial vehicle (UAV) technology, as tool of littoral cartography analysis of these bioconstructions, and plaster hemispheres dissolution as a descriptor index…
A comparative study of the mollusc communities of a Mediterranean saltwork (Marsala, Western Sicily.
2018
Saltworks are peculiar artificial ecosystems and holds great interest for basic research. In fact the cooling vat (the first pond of the evaporating series) is a good example of a relatively closed area and can be considered an excellent in the field open-air laboratory, namely a mesocosm reproducing a simplified model of the natural condition of hyperaline lagoons. The aim of the present work was to analyse the structure, composition and distribution of molluscan assemblages and to identify the faunistic relationships between the cooling vat and the neighbouring basin of Stagnone di Marsala, beside considering exchanges between saltwork, Stagnone di Marsala and sea, on soft- bottom, covere…