Search results for "SDI"
showing 10 items of 595 documents
Integrative genomic and proteomic analyses identify targets for Lkb1 deficient metastatic lung tumors
2010
SummaryIn mice, Lkb1 deletion and activation of KrasG12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and metastatic de novo lung cancers with integrated genomic and proteomic profiles, and have identified gene and phosphoprotein signatures associated with Lkb1 loss and progression to invasive and metastatic lung tumors. These studies revealed that SRC is activated in Lkb1-deficient primary and metastatic lung tumors, and that the combined inhibition of SRC, PI3K, and MEK1/2 resulted in synergistic tumor regression. These studies demonstrate that integrated genomic and proteomic analyses can be used to identify signaling pathw…
La regulación emocional en el ámbito de la atención primaria
2018
Las emociones tienen un papel importante en los procesos adaptativos y desadaptativos, ya que las personas influyen en las emociones que tienen y en cómo las expresan y experimentan, por lo que los trastornos emocionales se relacionan con una regulación emocional disfuncional. Estos trastornos presentan una alta prevalencia entre la población general, y más en concreto en las consultas de atención primaria. Los más prevalentes son la depresión, la ansiedad y las somatizaciones, es decir, aquellos que están relacionados con procesos emocionales. En esta línea, los déficits en regulación emocional parecen ser relevantes para el desarrollo, mantenimiento y tratamiento de distintas formas de ps…
The relationship of symptom dimensions with premorbid adjustment and cognitive characteristics at first episode psychosis: Findings from the EU-GEI s…
2021
Premorbid functioning and cognitive measures may reflect gradients of developmental impairment across diagnostic categories in psychosis. In this study, we sought to examine the associations of current cognition and premorbid adjustment with symptom dimensions in a large first episode psychosis (FEP) sample. We used data from the international EU-GEI study. Bifactor modelling of the Operational Criteria in Studies of Psychotic Illness (OPCRIT) ratings provided general and specific symptom dimension scores. Premorbid Adjustment Scale estimated premorbid social (PSF) and academic adjustment (PAF), and WAIS-brief version measured IQ. A MANCOVA model examined the relationship between symptom di…
Smiling is Fun, an online intervention for the prevention and treatment of emotional disorders
2016
Los trastornos emocionales representan una problemática en Salud Mental que conlleva un elevado costo personal y social, por lo que diseñar herramientas para su tratamiento y prevención es uno de los desafíos actuales de la psicología clínica. El programa Sonreír es Divertido es un sistema online diseñado bajo la perspectiva transdiagnóstica y el protocolo unificado de Barlow. En este trabajo se presenta una descripción del programa y datos preliminares de su eficacia, obtenidos en un estudio piloto llevado a cabo en España. El programa se muestra capaz de disminuir la sintomatología depresiva y ansiosa, así como de mejorar el afecto positivo y negativo de los participantes. Estos datos pre…
Boundary Regularity for the Porous Medium Equation
2018
We study the boundary regularity of solutions to the porous medium equation $u_t = \Delta u^m$ in the degenerate range $m>1$. In particular, we show that in cylinders the Dirichlet problem with positive continuous boundary data on the parabolic boundary has a solution which attains the boundary values, provided that the spatial domain satisfies the elliptic Wiener criterion. This condition is known to be optimal, and it is a consequence of our main theorem which establishes a barrier characterization of regular boundary points for general -- not necessarily cylindrical -- domains in ${\bf R}^{n+1}$. One of our fundamental tools is a new strict comparison principle between sub- and superpara…
Unique continuation property and Poincar�� inequality for higher order fractional Laplacians with applications in inverse problems
2020
We prove a unique continuation property for the fractional Laplacian $(-\Delta)^s$ when $s \in (-n/2,\infty)\setminus \mathbb{Z}$. In addition, we study Poincar\'e-type inequalities for the operator $(-\Delta)^s$ when $s\geq 0$. We apply the results to show that one can uniquely recover, up to a gauge, electric and magnetic potentials from the Dirichlet-to-Neumann map associated to the higher order fractional magnetic Schr\"odinger equation. We also study the higher order fractional Schr\"odinger equation with singular electric potential. In both cases, we obtain a Runge approximation property for the equation. Furthermore, we prove a uniqueness result for a partial data problem of the $d$-…
Decoupling on the Wiener Space, Related Besov Spaces, and Applications to BSDEs
2021
We introduce a decoupling method on the Wiener space to define a wide class of anisotropic Besov spaces. The decoupling method is based on a general distributional approach and not restricted to the Wiener space. The class of Besov spaces we introduce contains the traditional isotropic Besov spaces obtained by the real interpolation method, but also new spaces that are designed to investigate backwards stochastic differential equations (BSDEs). As examples we discuss the Besov regularity (in the sense of our spaces) of forward diffusions and local times. It is shown that among our newly introduced Besov spaces there are spaces that characterize quantitative properties of directional derivat…
Manifolds of quasiconformal mappings and the nonlinear Beltrami equation
2014
In this paper we show that the homeomorphic solutions to each nonlinear Beltrami equation $\partial_{\bar{z}} f = \mathcal{H}(z, \partial_{z} f)$ generate a two-dimensional manifold of quasiconformal mappings $\mathcal{F}_{\mathcal{H}} \subset W^{1,2}_{\mathrm{loc}}(\mathbb{C})$. Moreover, we show that under regularity assumptions on $\mathcal{H}$, the manifold $\mathcal{F}_{\mathcal{H}}$ defines the structure function $\mathcal{H}$ uniquely.
Self-improvement of pointwise Hardy inequality
2019
We prove the self-improvement of a pointwise p p -Hardy inequality. The proof relies on maximal function techniques and a characterization of the inequality by curves.
The Poisson embedding approach to the Calderón problem
2020
We introduce a new approach to the anisotropic Calder\'on problem, based on a map called Poisson embedding that identifies the points of a Riemannian manifold with distributions on its boundary. We give a new uniqueness result for a large class of Calder\'on type inverse problems for quasilinear equations in the real analytic case. The approach also leads to a new proof of the result by Lassas and Uhlmann (2001) solving the Calder\'on problem on real analytic Riemannian manifolds. The proof uses the Poisson embedding to determine the harmonic functions in the manifold up to a harmonic morphism. The method also involves various Runge approximation results for linear elliptic equations.