Search results for "SECR"
showing 10 items of 1169 documents
Victor Schoelcher, républicain et Franc-Maçon
2000
Parution d'une 2e édition corrigée en juin 2019 : Anne Ulrich-Girollet. "Victor Schoelcher, républicain et franc-maçon", Paris : ÉDIMAF, 2e éd., 2019, 114 p; Victor Schoelcher (1804-1893) est surtout connu pour sa participation déterminante à l'abolition de l'esclavage (1848). Cependant, son combat s'inscrit dans sa défense humaniste, mais non utopique, d'une République démocratique et sociale. Républicain, Schoelcher est également Franc-Maçon. Cet ouvrage se propose de mettre en perspective les liens entre l'action républicaine de Schoelcher et la Franc-Maçonnerie et les principes maçonniques. Si Schoelcher n'a pas toujours une activité maçonnique assidue, il n'en est pas moins un Franc-Ma…
Le parcours maçonnique d’un abolitionniste
2018
National audience; Victor Schoelcher s’engagea durant sa jeunesse dans des sociétés secrètes pour lutter contre le régime monarchique et les loges franc-maçonnes lui ont préparé le terrain aux Antilles. Pour autant, son activité maçonnique ne fut pas continue : comme en politique, il a pris ce qui lui semblait être le meilleur sans se sentir obligé d’adhérer complètement à une doctrine.
Victor Schoelcher, républicain et franc-maçon
2019
2e édition; International audience; Victor Schoelcher est surtout connu pour sa participation déterminante à l’abolition de l’esclavage. Or, celle-ci s’inscrit dans son combat, sans relâche, pour une République démocratique et sociale, vertueuse et philanthrope, même sous un État républicain. Durant sa jeunesse, antimonarchiste, il fait partie de sociétés secrètes ainsi que de loges maçonniques pour militer en faveur de l’instauration de la République. Puis, si Schoelcher n’a pas toujours une activité maçonnique assidue, il n’en fut pas moins un Franc-Maçon. Les principes maçonniques, Schoelcher les a non seulement vécus, mais encore défendus de façon acharnée.Schoelcher a été élevé au rang…
Victor Schoelcher et la franc-maçonnerie
2001
International audience; Victor Schoelcher (1804-1893) est un bel exemple de militantisme républicain car il a mené, tout au long de sa vie, un combat sans relâche, pour une République démocratique et sociale, vertueuse et philanthrope. Son action déterminante pour l'abolition de l'esclavage de 1848 s'inscrit, chez lui, dans une défense humaniste mais non utopique des principes républicains. Radical dès son plus jeune âge, Schoelcher est un républicain de la veille. Sous la Restauration et la monarchie de Juillet, il milite déjà avec ferveur pour la République. C'est pourquoi, lorsqu'il devient franc-maçon, il fait partie de la fraction la plus militante de la franc-maçonnerie. Sous la Resta…
PCOS Phenotypes: Impact on Fertility
2018
Polycystic ovary syndrome (PCOS) is characterised by an extreme heterogeneity and at least four main phenotypes may be distinguished. In referred population, anovulatory hyperandrogenic phenotype (classic PCOS or phenotypes A and B) is by far the most common phenotype and presents the most severe endocrine and metabolic alterations. Ovulatory PCOS and normoandrogenic phenotype represent a mild form of PCOS that is more common in general population and/or (normoandrogenic) in some particular ethnic group. During their life, because of changes in lifestyle or because of spontaneous changes in ovarian and adrenal androgen secretion that occur during late reproductive age, patients may move fro…
Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases.
2008
The receptor for advanced glycation end products (RAGE) is a 55-kDa type I membrane glycoprotein of the immunoglobulin superfamily. Ligand-induced up-regulation of RAGE is involved in various pathophysiological processes, including late diabetic complications and Alzheimer disease. Application of recombinant soluble RAGE has been shown to block RAGE-mediated pathophysiological conditions. After expression of full-length RAGE in HEK cells we identified a 48-kDa soluble RAGE form (sRAGE) in the culture medium. This variant of RAGE is smaller than a 51-kDa soluble version derived from alternative splicing. The release of sRAGE can be induced by the phorbol ester PMA and the calcium ionophore c…
The Role of the α Cell in the Pathogenesis of Diabetes: A World beyond the Mirror
2021
Type 2 Diabetes Mellitus (T2DM) is one of the most prevalent chronic metabolic disorders, and insulin has been placed at the epicentre of its pathophysiological basis. However, the involvement of impaired alpha (α) cell function has been recognized as playing an essential role in several diseases, since hyperglucagonemia has been evidenced in both Type 1 and T2DM. This phenomenon has been attributed to intra-islet defects, like modifications in pancreatic α cell mass or dysfunction in glucagon’s secretion. Emerging evidence has shown that chronic hyperglycaemia provokes changes in the Langerhans’ islets cytoarchitecture, including α cell hyperplasia, pancreatic beta (β) cell dedifferentiati…
The Effect of High Parathyroid Hormone Concentration on Calcitonin in Patients with Primary Hyperparathyroidism2)
2009
Serum calcitonin (CT), parathyroid hormone (PTH), and calcium levels were measured in 23 patients with primary hyperparathyroidism. PTH was determined by a midregion (M-RIA) and a carboxyl-terminal (C-RIA) specific PTH-RIA. Only 2 patients had elevated CT levels. In contrast to the findings in 46 healthy controls, the CT levels did not correlate with calcium levels. Patients who had the highest iPTH values showed a negative correlation between CT and iPTH (M-RIA (n = 7): R = -1.0000, p less than 0.001; C-RIA (n = 13): R = -0.5604, p less than 0.05). The results of the C-RIA were subtracted from those of the M-RIA. In 12 patients with the highest levels of intact PTH (M-RIA - C-RIA), serum P…
Retinoids as a Perspective in Treatment of Alzheimer’s Disease
2010
<i>Background:</i> In the past, we demonstrated that the disintegrin metalloproteinase ADAM10 has α-secretase activity in vitro and in cultured cells. We also found out that moderate overexpression of this proteinase inhibits Aβ peptide production and prevents the formation of amyloid plaques in an Alzheimer’s disease (AD) mouse model. Moreover, it corrects early hippocampal defects like LTP impairment and increases cortical synaptogenesis. <i>Objective:</i> Upregulation of ADAM10 might be an alternative approach concerning AD therapy. Our current research therefore focuses on substances and/or pathways which regulate ADAM10 gene expression. <i>Methods:</i&g…
Immunohistochemical localization of the pro-peptide processing enzymes PC1/PC3 and PC2 in the human anal canal.
1997
Abstract HORsch, D., R. Day, N. G. Seidah, E. Weihe and M. K.-H. SchAFer. Immunohistochemical localization of the pro-peptide processing enzymes PC1/PC3 and PC2 in the human anal canal. Peptides 18(5) 755–760, 1997.—The distribution of prohormone/pro-peptide convertases PC1/PC3 and PC2 was investigated in the human anal canal by immunohistochemistry. Both prohormone convertases exhibited region-specific distribution patterns and were observed in neural and neuroendocrine cells and in nonneuroendocrine cellular elements. PC1/PC3 immunoreactivity was present in enteric neurons, subsets of nerve fibers, and neuroendocrine cells, and also in epithelial cells like intestinal stem cells, and a su…