Search results for "SELE"
showing 10 items of 4721 documents
Search for a diffuse flux of astrophysical muon neutrinos with the IceCube 59-string configuration
2013
A search for high-energy neutrinos was performed using data collected by the IceCube Neutrino Observatory from May 2009 to May 2010, when the array was running in its 59-string configuration. The data sample was optimized to contain muon neutrino induced events with a background contamination of atmospheric muons of less than 1%. These data, which are dominated by atmospheric neutrinos, are analyzed with a global likelihood fit to search for possible contributions of prompt atmospheric and astrophysical neutrinos, neither of which have yet been identified. Such signals are expected to follow a harder energy spectrum than conventional atmospheric neutrinos. In addition, the zenith angle dist…
Avian Clock gene polymorphism: evidence for a latitudinal cline in allele frequencies
2007
In comparison with most animal behaviours, circadian rhythms have a well-characterized molecular genetic basis. Detailed studies of circadian clock genes in 'model' organisms provide a foundation for interpreting the functional and evolutionary significance of polymorphic circadian clock genes found within free-living animal populations. Here, we describe allelic variation in a region of the avian Clock orthologue which encodes a functionally significant polyglutamine repeat (ClkpolyQcds), within free-living populations of two passerine birds, the migratory bluethroat (Luscinia svecica) and the predominantly nonmigratory blue tit (Cyanistes caeruleus). Multiple ClkpolyQcds alleles were foun…
Mitochondrial genetic haplogroups and incident obesity: a longitudinal cohort study.
2018
Background/Objectives: A small number of case-control studies have suggested that mitochondrial haplogroups could be associated with obesity. We examined whether obesity risk was influenced by mitochondrial haplogroup in a large North American cohort across an 8-year period. We conducted a longitudinal cohort study including individuals from the Osteoarthritis Initiative. Subjects/Methods: Mitochondrial haplogroups were determined by sequencing and PCR-RFLP techniques using this nomenclature: HV, JT, KU, IWX, and super HV/others. The strength of the association between mitochondrial haplogroups and incident obesity was quantified with hazard ratios (HRs), adjusted for potential confounders …
First Observation of PeV-Energy Neutrinos with IceCube
2013
We report on the observation of two neutrino-induced events which have an estimated deposited energy in the IceCube detector of 1.04 $\pm$ 0.16 and 1.14 $\pm$ 0.17 PeV, respectively, the highest neutrino energies observed so far. These events are consistent with fully contained particle showers induced by neutral-current $\nu_{e,\mu,\tau}$ ($\bar\nu_{e,\mu,\tau}$) or charged-current $\nu_{e}$ ($\bar\nu_{e}$) interactions within the IceCube detector. The events were discovered in a search for ultra-high energy neutrinos using data corresponding to 615.9 days effective livetime. The expected number of atmospheric background is $0.082 \pm 0.004 \text{(stat)}^{+0.041}_{-0.057} \text{(syst)}$. T…
Competición intrasexual en el trabajo: diferencias sexuales en celos y envidia en el trabajo
2012
ResumenDesde una perspectiva evolucionista, este articulo aborda las diferencias sexuales en las caracteristicas del rival que provocan celos y envidia en el trabajo, y como se relacionan con la competicion intrasexual. La muestra estuvo compuesta por 114 trabajadores de diferentes sectores profesionales. Los rivales provocaron mas celos y envidia en las mujeres que en los hombres cuando eran fisicamente atractivos. En ambos sexos, las habilidades sociales y el poder social y dominancia fueron las caracteristicas del rival que provocaron mas celos y envidia. En las mujeres, los celos provocados por el atractivo fisico del rival se relacionaron con la competicion intrasexual, mientras que en…
Rapid evolutionary adaptation to elevated salt concentrations in pathogenic freshwater bacteria Serratia marcescens.
2014
Rapid evolutionary adaptions to new and previously detrimental environmental conditions can increase the risk of invasion by novel pathogens. We tested this hypothesis with a 133-day-long evolutionary experiment studying the evolution of the pathogenic Serratia marcescens bacterium at salinity niche boundary and in fluctuating conditions. We found that S. marcescens evolved at harsh (80 g/L) and extreme (100 g/L) salt conditions had clearly improved salt tolerance than those evolved in the other three treatments (ancestral conditions, nonsaline conditions, and fluctuating salt conditions). Evolutionary theories suggest that fastest evolutionary changes could be observed in intermediate sele…
Importance de la variabilité génétique bactérienne sur le fonctionnement de la symbiose Rhizobium leguminosarum biovar viciae avec le pois (Pisum sat…
2008
Les irrégularités de rendement et de teneur en protéine des graines que présente la culture du pois sont, en partie, liées à des problèmes de nutrition azotée. En tant que légumineuse, la nutrition azotée du pois repose à la fois sur la fixation symbiotique de l’azote atmosphérique et sur l’absorption racinaire des nitrates du sol. Notre principal objectif a été de déterminer si le partenaire bactérien, Rhizobium leguminosarum biovar viciae (Rlv), peut être un facteur limitant de la nutrition azotée et du rendement du pois. La variabilité génétique des Rlv et les facteurs influençant la structure des populations de Rlv à l'état libre et symbiotiques ont été étudiés. La signification de la d…
Evolved high aerobic capacity has context-specific effects on gut microbiota
2022
Publisher Copyright: Copyright © 2022 Hanhimäki, Watts, Koskela, Koteja, Mappes and Hämäläinen. Gut microbiota is expected to coevolve with the host's physiology and may play a role in adjusting the host's energy metabolism to suit the host's environment. To evaluate the effects of both evolved host metabolism and the environmental context in shaping the gut microbiota, we used a unique combination of (1) experimental evolution to create selection lines for a fast metabolism and (2) a laboratory-to-field translocation study. Mature bank voles Myodes glareolus from lines selected for high aerobic capacity (A lines) and from unselected control (C lines) were released into large (0.2 ha) outdo…
Selēnsaturošo aminoskābju noteikšana brokoļos
2017
Selēnsaturošo aminoskābju noteikšana brokoļos. Graudiņa L., zinātniskā vadītāja Dr.ķīm. Nakurte I. Maģistra darbs, 43 lappuses, 23 literatūras avoti, 17 attēli, 9 tabulas, 1 pielikumi. Latviešu valodā. Veicot literatūras izpēti, tika iegūts priekšstats par selēna iedarbību uz cilvēka organismu. Tika apskatītas arī optimālākās paraugu sagatavošanas metodes un populārākās analīzes metodes selēnsaturošo aminoskābju izdalīšanai un noteikšanai augu valsts produktos. Maģistra darba praktiskajā daļā pētīti trīs veikalā nopērkami brokoļu paraugi, kā arī pašu diedzētie brokoļu dīgsti. Selēnsaturošo aminoskābju izdalīšanai no paraugiem izmantotas divas ekstrakcijas metodes. Pētāmo savienojumu noteikš…
Aptamēru atlase pret urīnpūšļa audzēja mērķproteīnu Nectin–4 raksturīgiem proteīniem
2022
Urīnpūšļa vēzis ir viens no visvairāk diagnosticētajiem vēžiem pasaulē, taču tā diagnostikai un terapijai nepieciešamas jaunas metodes, lai veiksmīgāk atklātu un varētu ārstēt šo slimību. Šo lomu var veikt mērķterapijas zāles, piemēram aptamēri vai antivielas. Šajā darbā veicām aptamēru proteīnu-SELEX atlasi uz urīnpūšļa membrānas paaugstināti ekspresētu proteīnu – nectin-4, uz kuru jau ir izveidotas un klīnikā izmantotas antivielu terapijas zāles. Šajā darbā vēlējāmies, veicot sekvenču bibliotēkas apstrādi, SELEX atlasi un sekvencēšanu, iegūt līdersekvences ar spēju specifiski saistīties uz attīrītu nectin-4 proteīnu. Rezultātā tika iegūtas trīs līdersekvences ar potenciālu kļūt par aptamē…