Search results for "SEP"
showing 10 items of 2642 documents
Neuronal nitric oxide synthase modulates maturation of human dendritic cells.
2010
AbstractDendritic cells (DCs) are the most potent APCs of the immune system. Understanding the intercellular and intracellular signaling processes that lead to DC maturation is critical for determining how these cells initiate T cell-mediated immune processes. NO synthesized by the inducible NO synthase (iNOS) is important for the function of murine DCs. In our study, we investigated the regulation of the arginine/NO-system in human monocyte-derived DCs. Maturation of DCs induced by inflammatory cytokines (IL-1β, TNF, IL-6, and PGE2) resulted in a pronounced expression of neuronal NOS (nNOS) but only minimal levels of iNOS and endothelial NOS were detected in human mature DCs. In addition, …
New therapies for sepsis: focus on the interleukin (IL)12 family member IL27
2007
Sepsis is a severe complication of abdominal infections such as peritonitis and is associated with high mortality. Unfortunately, the molecular mechanisms controlling the development of sepsis are still incompletely understood. Interestingly, the interleukin (IL) 12 family member IL27 seems to play a key role in sepsis. In a murine model of septic peritonitis induced by caecal ligation and puncture (CLP), IL27 levels were found to be strongly induced. Furthermore, mice deficient for the EBI3 subunit of IL27 were resistant to CLP-induced septic peritonitis as compared to wild-type controls. This effect could be suppressed by injection of recombinant IL27. Further studies demonstrated that IL…
Thermal potential of ion-exchange membranes and its application to thermoelectric power generation
2016
The low efficiency and high price of thermoelectric semiconductors has generated interest in unconventional forms of thermoelectric materials. In this article, ionic thermoelectricity has been studied with commercial ion-exchange membranes for different aqueous 1:1 electrolytes. The theory of thermal membrane potential has been derived taking into account the ionic heats of transport, the non-isothermal Donnan potentials, the temperature polarization, and the thermally-induced concentration polarization of the electrolyte. Also the generated thermoelectric power has been experimentally studied. The experiments show good agreement with the theory, and suggest ways for systematic improvement …
Type-II transmembrane prolyl dipeptidases and matrix metalloproteinases in membrane vesicles of active endothelial cells.
2006
Conclusions: Endothelia cells in sparse culture are migratory and increase the production of gelatinases of serine- and metallo-classes in membrane vesicles. Collectively, proteases associated with membrane vesicles degrade extracellular matrix components including type-I and type-IV collagens, laminin and fibronectin. Inhibitor studies suggest the existence of small gelatinases that were derived from these serine- and metallo-proteases. Thus, further studies are warranted to demonstrate the cooperative action of metallo- and serine proteases on cell surfaces and in extracellular vesicles during endothelial cell migration in 3D collagenous matrices, and potential proteolytic activation mech…
Louise Glück: Talvisia reseptejä kollektiivista
2022
Formulations and valid inequalities for the capacitated dispersion problem
2023
This work focuses on the capacitated dispersion problem for which we study several mathematical formulations in different spaces using variables associated with nodes, edges, and costs. The relationships among the presented formulations are investigated by comparing the projections of the feasible sets of the LP relaxations onto the subspace of natural variables. These formulations are then strengthened with families of valid inequalities and variable-fixing procedures. The separation problems associated with the valid inequalities that are exponential in number are shown to be polynomially solvable by reducing them to longest path problems in acyclic graphs. The dual bounds obtained from s…
Gozos a la gloriosa virgen Santa Tecla Proto-Martir de las mugeres, que se venera en su ... Monasterio de Religiosas del Orden del Gran Padre San Agu…
1750
El full orlat Grav. xil. enmarcat de la santa, flanquejat per gerros amb flors El text del goig a tres col. separades per filets
Gozos a la gloriosa virgen Santa Tecla Proto-Martir de las mugeres, que se venera en su ... Monasterio de Religiosas del Orden del Gran Padre San Agu…
El full orlat Grav. xil. enmarcat de la santa, flanquejat per gerros amb flors El text del goig a tres col. separades per filets
La vida y muerte del hombre justo, propuesta en los exemplos de San Josef, esposo de Maria Santissima : sacada del Evangelio, segun la interpretacion…
Menció de responsabilitat presa de Palau El f. de grav. calc. representa a "El patriarca S. Jose" Port. amb vinyeta xil Frisos tip. i inicials decorades Sign.: [ ]4, A-Z4, Aa-Ff4 Notes a peu de p Reclams
Scrittura giornalistica e impegno antimafia. Soluzioni testuali e scelte linguistiche in Mario Francese e Giuseppe Fava
2022
Gli studi sulle organizzazioni mafiose sono stati condotti, in molti casi, con una finalità non soltanto conoscitiva, ma anche di contrasto del fenomeno. In particolare, alla cosiddetta “antimafia” sono stati dedicati saggi specifici, tra i quali segnaliamo, per la ricchezza dei materiali e la profondità dell’analisi, la Storia del movimento antimafia di Umberto Santino (2009). Se pochi sono gli studi linguistici sulla lingua della mafia, praticamente nulli sono quelli sulla lingua dell’antimafia. La domanda da porsi, in effetti, è se davvero esista una lingua dell’antimafia, dotata dunque di tratti linguistici e testuali individuabili e peculiari. Per rispondere a questa domanda, in questo…