Search results for "SHED"
showing 10 items of 289 documents
Lack of evidence for infectious SARS-CoV-2 in feces and sewage
2021
Purpose: The SARS-CoV-2 coronavirus is a respiratory virus whose primary route of transmission is airborne. However, it has been shown that the virus can replicate in gastrointestinal cells, can be excreted in feces, and can reach sewage systems. Although viral RNA is known to be found in patient feces and sewage, little is known about the possible fecal-oral transmission of the coronavirus. Determining the presence of infective viral particles in feces and sewage is necessary to take adequate control measures and to discover new routes of coronavirus transmission. Here, we analyzed feces and urine of COVID-19 patients and wastewater samples at the time of high prevalence in the region unde…
Structural basis for the sheddase function of human meprin β metalloproteinase at the plasma membrane.
2012
Ectodomain shedding at the cell surface is a major mechanism to regulate the extracellular and circulatory concentration or the activities of signaling proteins at the plasma membrane. Human meprin β is a 145-kDa disulfide-linked homodimeric multidomain type-I membrane metallopeptidase that sheds membrane-bound cytokines and growth factors, thereby contributing to inflammatory diseases, angiogenesis, and tumor progression. In addition, it cleaves amyloid precursor protein (APP) at the β-secretase site, giving rise to amyloidogenic peptides. We have solved the X-ray crystal structure of a major fragment of the meprin β ectoprotein, the first of a multidomain oligomeric transmembrane sheddase…
Heritage and the anti-city. Pizzo Sella in Palermo between modern ruins tourism and civic reappropriation
2022
Tutte le nozioni di patrimonio mettono in risonanza i valori della memoria e quelli dell'ambiente antropizzato, poiché entrambi sono intesi come duraturi. Riferendosi al caso iconico della collina di Pizzo Sella a Palermo, questo lavoro affronta il legame peculiare che in questo caso si esprime tra patrimonio, paesaggio e turismo. Per interrogarsi sul modo in cui tale legame segna il rapporto di una comunità con il suo passato, questo contributo si concentra su una nozione critica di patrimonio, inteso come sistema da riconoscere nel costruito dei territori del conflitto fra Stato e criminalità. Questi luoghi, a lungo sotto il controllo delle organizzazioni criminali mafiose, oggi sono prof…
Isolation of the left atrial surface from cardiac multi-detector CT images based on marker controlled watershed segmentation
2006
The delineation of left atrium (LA) and pulmonary veins (PVs) anatomy from high resolution images holds importance for atrial fibrillation (AF) investigation and treatment. In this study, a semiautomatic segmentation procedure for LA and PVs inner surface from contrast enhanced CT data was developed. The procedure consists of a three dimensional marker controlled watershed segmentation applied to the external morphological gradient, followed by variable threshold surface extraction from the original intensity image. A preliminary anisotropic non-linear filtering was implemented to improve the S/N ratio of CT images. The performance of segmentation was evaluated on cardiac CT scans of 12 AF …
Assessing and mapping multi-hazard risk susceptibility using a machine learning technique
2020
AbstractThe aim of the current study was to suggest a multi-hazard probability assessment in Fars Province, Shiraz City, and its four strategic watersheds. At first, we construct maps depicting the most effective factors on floods (12 factors), forest fires (10 factors), and landslides (10 factors), and used the Boruta algorithm to prioritize the impact of each respective factor on the occurrence of each hazard. Subsequently, flood, landslides, and forest fire susceptibility maps prepared using a Random Forest (RF) model in the R statistical software. Results indicate that 42.83% of the study area are not susceptible to any hazards, while 2.67% of the area is at risk of all three hazards. T…
The crystal structure of a 250-kDa heterotetrameric particle explains inhibition of sheddase meprin β by endogenous fetuin-B
2021
Meprin β (Mβ) is a multidomain type-I membrane metallopeptidase that sheds membrane-anchored substrates, releasing their soluble forms. Fetuin-B (FB) is its only known endogenous protein inhibitor. Herein, we analyzed the interaction between the ectodomain of Mβ (MβΔC) and FB, which stabilizes the enzyme and inhibits it with subnanomolar affinity. The MβΔC:FB crystal structure reveals a ∼250-kDa, ∼160-Å polyglycosylated heterotetrameric particle with a remarkable glycan structure. Two FB moieties insert like wedges through a “CPDCP trunk” and two hairpins into the respective peptidase catalytic domains, blocking the catalytic zinc ions through an “aspartate switch” mechanism. Uniquely, the …
Graduate of Riga Polytechnic Institute, Engineer and Athlete Mārtiņš Stabiņš
2020
The aim of the article is to reveal the performance of Mārtiņš Stabiņš, a graduate of the Faculty of Automation and Computer Technology (1972; FACT) of Riga Polytechnic Institute (RPI), in the profession of engineer and high achievements in sports, becoming a Latvian champion in athletics several times, to reveal his daily life during his study years in the 1960s–1970s. Despite the fact that M. Stabiņš’ sports achievements have already described, this article summarizes his successes as well as reveals hitherto little-known and unpublished documents about his family, daily life, developments and interests. This is the first major research on the life of an engineer and athlete during seven …
Correction to: When kidneys and lungs suffer together
2019
A significant interaction between kidneys and lungs has been shown in physiological and pathological conditions. The two organs can both be targets of the same systemic disease (eg., some vasculitides). Moreover, loss of normal function of either of them can induce direct and indirect dysregulation of the other one. Subjects suffering from COPD may have systemic inflammation, hypoxemia, endothelial dysfunction, increased sympathetic activation and increased aortic stiffness. As well as the exposure to nicotine, all the foresaid factors can induce a microvascular damage, albuminuria, and a worsening of renal function. Renal failure in COPD can be unrecognized since elderly and frail patients…
Erratum to: Development and validation of the FRAGIRE tool for assessment an older person’s risk for frailty
2016
Background Frailty is highly prevalent in elderly people. While significant progress has been made to understand its pathogenesis process, few validated questionnaire exist to assess the multidimensional concept of frailty and to detect people frail or at risk to become frail. The objectives of this study were to construct and validate a new frailty-screening instrument named Frailty Groupe Iso-Ressource Evaluation (FRAGIRE) that accurately predicts the risk for frailty in older adults. Methods A prospective multicenter recruitment of the elderly patients was undertaken in France. The subjects were classified into financially-helped group (FH, with financial assistance) and non-financially …
Testing cross-lagged relationships between work-related rumination and well-being at work in a three-wave longitudinal study across 1 and 2 years
2019
The aim of this three-wave longitudinal study conducted among 664 Finnish employees was to examine the cross-lagged relationships between various work-related ruminative thoughts (affective rumination, problem-solving pondering, lack of detachment from work) during off-job time and employee well-being (exhaustion, vigour). We tested normal, reversed, and reciprocal temporal relationships across 1 and 2 years using structural equation modelling. The analyses lent most support to the reversed temporal relationships, showing first that high exhaustion predicted low problem-solving pondering 2 years later and second, that high vigour predicted low affective rumination both 1 and 2 years later. …